New Monthly DK Column: The Currently Incurable Scientist

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

New Monthly DK Column: The Currently Incurable Scientist

Postby DK37 » Tue Jul 14, 2015 10:30 pm

I’m excited to announce that via connections with the help of the Colon Club, I have become the monthly Science Columnist for the national advocacy group “Fight Colorectal Cancer”.

The main message of today’s introductory column is an essay on why I am personally excited about new cancer drugs approaching and in clinical trials – excitement which translates into HOPE – for myself as well as I hope others. That is why I chose to call myself both “currently incurable” and “terminally optimistic”.

My goal in future columns is to explain the science behind experimental CRC drugs in an easily understood way. I love the science of oncology and I love explaining it to people, especially fellow patients! I hope that this information can help the CRC community & translate into better informed medical discussions with the patients’ medical teams!

And so it begins... http://fightcolorectalcancer.org/resear ... roduction/

Cheers,
-DK (shhhhhhhh, you now know my real name but thanks to Mr. Google constant snooping, I'll continue to stick with DK37 here :wink: )
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

Iitg ritesh
Posts: 165
Joined: Mon Aug 25, 2014 7:11 am
Location: WA

Re: New Monthly DK Column: The Currently Incurable Scientist

Postby Iitg ritesh » Tue Jul 14, 2015 10:47 pm

wow..great. you will be curable in near future with all trials you are taking. this is fabulous news.
32yo Dx@rectal cancer 05/10/13, CEA 3.4
chemoradiation, xeloda finished on 02/12/13
LAR surgery 22/01/14, pT3N0, 0/3 nodes, folfox 02/14--06/14 , 8 cycles folfox, 4 cycles of xeloda
Stricture due to radiation, diversion colitis
Reversal 14/10/14
NED

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CRguy
Posts: 9287
Joined: Sun Feb 10, 2008 6:00 pm

Re: New Monthly DK Column: The Currently Incurable Scientist

Postby CRguy » Wed Jul 15, 2015 12:34 am

Nicely done "DK" .... :shock:
excellent intro blog to your new assignment !

The ColonTalk forum has always had a lineage of science folks who share, as patients, caregivers ... and "science folks".
That is what sets us apart from other cancer support forums.... WE have people coming into this forum, AT this disease, from all angles.

You join a long and noble tradition here.
All your input has been well received and every future input will be much appreciated.

Cheers and Harmony my friend
always on a Journey
CRguy
Caregiver x 3
Stage IV A rectal cancer/lung met
10 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: New Monthly DK Column: The Currently Incurable Scientist

Postby DK37 » Wed Jul 15, 2015 7:34 am

Thanks for the note CR Guy!

This new blog won't change what I have been doing here - posting what I think are cool new info in basically real time! If anything, the Colon Talk folks will always get a headstart because in most instances I'll post things here first in real time as I find them and then try to consolidate into more public & word-count limited summaries for the monthly column. Since the columns will be organized by theme & only monthly, there actually may be a significant time lag for some things you read here first. Two different forums, two different styles - but serving the same purpose - helping patients understand the science. Active Colon Talk readers will recognize topics I have posted about here already. :) The anonymity of Colon Talk also allows me to speak a bit more freely than a public column with my face and full name on it! - which can be a positive or negative depending on what I say haha

Actually something just popped in my head: If there are any science topics, primarily pre-clinical or clinical trial drugs/treatment strategies, that match the general goal of the column that you guys want me to write about - list them in the comments below or PM me!
GrouseMan's recent post about Rose Bengel is an example - finding new uses of old compounds/drugs could be an interesting new column. Or my recent post about the power of blood biopsies. Obviously I'll eventually tackle the famous NCI TIL trial too, hopefully with Sleen as the column's success story posterchild!!

Anyhow - the pressure is on! :shock: Hopefully I don't let you guys down!

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

lhawk0730
Posts: 171
Joined: Mon Oct 27, 2014 10:49 pm

Re: New Monthly DK Column: The Currently Incurable Scientist

Postby lhawk0730 » Wed Jul 15, 2015 9:35 am

DK, this is awesome. Thank you for sharing. You really do make these topics exciting and easy to understand. Congratulations on this new venture! I am looking forward to reading each month.
Daughter to Mom, age 71
Dx 10/14 RC - T3bN1bM0
Chemoradiation til 1/15
Surgery 2/15
Temp ileostomy
Failed Xelox round 4/15
1 round straight Xeloda 5/15 - discontinued
Ileo reversal 5/15
8/15 more Xeloda

pfCml73183
Posts: 653
Joined: Sat Jun 22, 2013 7:49 pm
Facebook Username: Celeste Marie Comeau
Location: FL

Re: New Monthly DK Column: The Currently Incurable Scientist

Postby pfCml73183 » Wed Jul 15, 2015 2:56 pm

This is wonderful news, DK. I am so happy you are doing this.
Celeste
Wife and BF to Peter, 54
mCRC/IV/BRAF+
Erbitux and Urelumab trial @MSKCC 3/15
went home 5/8/15

smalltownmess
Posts: 84
Joined: Mon Aug 04, 2014 2:09 am

Re: New Monthly DK Column: The Currently Incurable Scientist

Postby smalltownmess » Wed Jul 15, 2015 3:46 pm

This is awesome, DK! It's going to be an awesome resource not only patients and caregivers, but also families that have questions but find themselves on the short end of the information stick. Thank you!
Mom diagnosed Stage 4 with Liver mets 7/2011
July 11: Xeloda and Avastin
August 13: Irinotecan
June 14: Disease Progression
August 14: SBRT
October 14 - December 14: RRX-001
January - May 15: Irinotecan
May 15: One week Stivarga -- stopped b/c DRESS Syndrome
July 15: Disease progression
July 15: Start Xelox

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Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: New Monthly DK Column: The Currently Incurable Scientist

Postby Nik Colon » Wed Jul 15, 2015 5:19 pm

Awesome! Congrats!
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

Ceebo
Posts: 132
Joined: Sat Feb 14, 2015 9:15 am
Location: Southwest Michigan

Re: New Monthly DK Column: The Currently Incurable Scientist

Postby Ceebo » Wed Jul 15, 2015 6:20 pm

Looking forward to reading your monthly column! So thankful for all the great information you share with all of us!
DH 64 Stage 4 on 4/14 ; cecal tumor; 5+ nodes ; mets to liver; colon resection
5/14 FOLFOX
9/14 - Liver surgery aborted; peri mets
10/14 CT mult.1-2 mm lung mets; FOLFIRI & Avastin
1/15 CT -liver & lung mets shrinking
3/15 PET - ? New met. site colon; CEA rising
7/15 Chemo has failed; looking for clinical trial
9/29/15 started TAS-102 trial
KRAS mutant; MSS

JENNJ
Posts: 115
Joined: Tue Feb 17, 2015 8:00 pm

Re: New Monthly DK Column: The Currently Incurable Scientist

Postby JENNJ » Thu Jul 16, 2015 7:47 pm

Congratulations! I am fairly new to the forum but really appreciate all you do!
Katy

WifeOfMike
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Facebook Username: https://www.facebook.com/vbass123
Location: San Diego, California

Re: New Monthly DK Column: The Currently Incurable Scientist

Postby WifeOfMike » Sat Jul 18, 2015 7:45 pm

DK......
YOU simply ROCK!!!
many Hugs, many Thanks for ALL that YOU do.
Vicki

Image
Bad Ass WIFE
Hubs: CRC IVA,T3, N0, M1A
Resect/LN Mets 10/12
Folfox4/Avastin 11/12-5/13
Folfiri/Erbitux 6/13-10/13
Stivarga 12/13-4/14
Trial 4/14-/14
Trial 8/14-11/14
HOME Hospice 11/17/14
Guardian Angel 1/1/15
Cost of HOPE? PRICELESS

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: New Monthly DK Column: The Currently Incurable Scientist

Postby DK37 » Mon Jul 20, 2015 10:58 pm

Holy crap Vicki that is the BIGGEST smiley face I have ever received (seen?)!! Thank you, brought a huge smile to my face to see it! :D

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

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bitchslapped
Posts: 1349
Joined: Tue Sep 09, 2014 3:23 pm
Location: PNW/USA

Re: New Monthly DK Column: The Currently Incurable Scientist

Postby bitchslapped » Fri Jul 24, 2015 2:24 am

Well, I can't outdo Sister Vicki, but I can say congrats, I'm glad you accepted & look forward to reading your columns. So far so good DK!

Best Wishes
BS
DSS,35YO,unresect mCRC DX 7/'14,lvr,LN,peri,rib
FOLFOX+Avstn 4 Rnds d/c 10/'14
Stent 9/'14
FOLFIRI+Avstn 10/'14
Gone From My Sight 2/20/15
Me:garden variety polyps + precancerous polyp
Carergver x2 DH,DM dbl occupancy,'03-'10
DH dx 47YO mCRC,'04-'07 fried x HAI
DM dx CC 85YO,CC,CHF,stroke,dementia,aphasia

behconsult
Posts: 219
Joined: Fri Jul 04, 2014 4:53 pm

Re: New Monthly DK Column: The Currently Incurable Scientist

Postby behconsult » Sat Jul 25, 2015 9:58 pm

Great work both on the page and in the field. Thank you Bob
Stage 3B Age 52
T4; 2/16; spot on perit
Resctn 6/9/2014
Folfox strt 7/2014. 6 of 12 tx
Chemo induced DM2
Pet 4 mets to lung (1 cm, 6 mm) Xeloda/Avastin 9/16 to present.
Cryo-ablation to three spots- Collapsed lung/chest tube 5/17. One more spot to go.

jillbugs4110
Posts: 266
Joined: Thu Jul 31, 2014 3:36 pm

Re: New Monthly DK Column: The Currently Incurable Scientist

Postby jillbugs4110 » Sun Jul 26, 2015 4:04 pm

Cannot express the gratitude I feel toward you. I am far from a scientists just a layman I am grateful for you selfless gift of time.
Live One Day At A Time
I Abandon myself to God
46 6 yo.....9yo...
stage 1V liver mets :-(
my one prayer to got to sustain me to raise my two babies this is my only wish then take me out if needed.


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