atezolizumab (Mpdl3280a)& avastin phase 1 trial update

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Travelgirl
Posts: 123
Joined: Sun Dec 20, 2015 4:17 am
Facebook Username: Jac gar
Location: Florida

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby Travelgirl » Tue Dec 29, 2015 7:47 pm

That is wonderful news.. Please keep us posted.. God Bless.. :D
Travel Girl
53/F
DX-CC 12/19/15
Tumor location Cecum
Tumor Type -Adenocarcinoma arising background sessile serrated polyp high grade dysplasia
Tumor size 1.5 cm
TNM - T1, N0, M0
Stage 1
Baseline 12/15 CEA 2.4, 8/16 CEA 1.7,11/15 CEA 2.3
Surgical Margins Clear
Lynch - Neg
Primary Surgery 1/11/16 LAR right colon and portion of ileum right hemicolectomy
1/4 follicular lymphoma- Wait n Watch (found in CT scan for Colon cancer) a 2 for 1 special.
8/16/16 NED for Colon/Lymphoma nodes have shrunk on their own.

StephenWinsToday
Posts: 39
Joined: Mon Jun 22, 2015 12:08 pm
Facebook Username: Stephen Savage-Estrada

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby StephenWinsToday » Thu Dec 31, 2015 7:45 pm

Scan results are in! I'm stable again, but this time they think there may have been slight shrinkage. This makes about 6 months of stability.
7/15 DX'd at age 28 w/stage 4 crc. Met to mesentery. Also lynch+
7/15 right hemicolectomy
8/15 started 12 rounds FOLFOX.
2/15 Nanoknife. Gallbladder removal. resections. Complications landed me in ICU for 1 week. 8 blood transfusions.
5/15 Nanoknife failed. Enrolled in phase 1 trial of MPDL3280a (Atezolizumab) & Avastin.
7/15 CT shows I am responding to trial drug. All tumors and nodules shrinking.
8/15 CT scan shows stability of all nodules and target tumor
10/15 CT scan shows continued stability.

mariane
Posts: 704
Joined: Sun Sep 13, 2015 6:16 pm

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby mariane » Thu Dec 31, 2015 11:15 pm

Congratulations! :) I wish you the best, durable response to atezolizumab and cure at the end of this road!
mom of now 14 years old twins, dx @ 40 in 6/2015 with upper rectal cancer, 10+ liver mets, CEA 140
chemo: 8/2015 - 10/2016 - 4xFOLFIRINOX, 2xFOLFOX, 8xFOLFIRI, 10x5FU, HAI pump -12xFUDR
4 surgeries, complete pathological response
CEA<2 since 10/2015
NED since May 2016

I praise God for every day with my family!

jortego128
Posts: 288
Joined: Sat Aug 15, 2015 7:47 am

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby jortego128 » Fri Jan 01, 2016 8:37 pm

Awesome man! Congrats!
DM 57 yrs old dx 6/8/15 T:4a N:1b M:1
KRAS G12D and TP53 C242fs mutations
Poorly Differentiated, Prominent Signet Ring Component(~50%)
Microsatellite Stable, 3 of (13)lymph nodes positive
15 Liver mets, largest 3.2 cm
Prim. Resection, Right Hemicolectomy 6/21/15
Start Chemo 7/20/15
2 rounds FOLFOX, 1 round FOLFOX +Avastin
CT 8/28/15, met growth, largest 4.5cm
4 rounds FOLFOX+Avastin
CT 11/06/15 mets stable, lungs clear
Begin FOLFIRI+Avastin 11/17/15, Stop chemo 1/26/16
Entered Paradise 3/11/2016

StephenWinsToday
Posts: 39
Joined: Mon Jun 22, 2015 12:08 pm
Facebook Username: Stephen Savage-Estrada

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby StephenWinsToday » Thu Mar 24, 2016 12:41 pm

Had another scan today.

I am still considered stable with a slight decrease in the primary tumor and slight decrease in the nodules. I'll take it!

Atezolizumab has been a literal life safer!
7/15 DX'd at age 28 w/stage 4 crc. Met to mesentery. Also lynch+
7/15 right hemicolectomy
8/15 started 12 rounds FOLFOX.
2/15 Nanoknife. Gallbladder removal. resections. Complications landed me in ICU for 1 week. 8 blood transfusions.
5/15 Nanoknife failed. Enrolled in phase 1 trial of MPDL3280a (Atezolizumab) & Avastin.
7/15 CT shows I am responding to trial drug. All tumors and nodules shrinking.
8/15 CT scan shows stability of all nodules and target tumor
10/15 CT scan shows continued stability.

Travelgirl
Posts: 123
Joined: Sun Dec 20, 2015 4:17 am
Facebook Username: Jac gar
Location: Florida

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby Travelgirl » Thu Mar 24, 2016 12:56 pm

Excellent that is great news... :D God bless...have a great Easter
Travel Girl
53/F
DX-CC 12/19/15
Tumor location Cecum
Tumor Type -Adenocarcinoma arising background sessile serrated polyp high grade dysplasia
Tumor size 1.5 cm
TNM - T1, N0, M0
Stage 1
Baseline 12/15 CEA 2.4, 8/16 CEA 1.7,11/15 CEA 2.3
Surgical Margins Clear
Lynch - Neg
Primary Surgery 1/11/16 LAR right colon and portion of ileum right hemicolectomy
1/4 follicular lymphoma- Wait n Watch (found in CT scan for Colon cancer) a 2 for 1 special.
8/16/16 NED for Colon/Lymphoma nodes have shrunk on their own.

Snapfish
Posts: 50
Joined: Mon Oct 05, 2015 10:42 pm
Location: Washington, DC (dad in Houston, TX)

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby Snapfish » Sat Mar 26, 2016 1:06 pm

So wonderful!!!!
Daughter to 70-year old father dx 2015-Sept-28: Stage IV adenocarcinoma with signet ring cell features
Sigmoid colon primary with peri mets
MSS; RAS wild-type; mutation in exon 8 of p53

2015-Oct: Began FOLFOX-6 at MDA; CEA was 15.1 at baseline
2016-Feb: CEA 5.7; 10 full rounds of FOLFOX-6 completed
2016-Mar-3: Began FOLFIRI
chemo, chemo, chemo
2017-Jan: Total of 29 cycles of chemo down. Back on FOLFOX again after FOLFIRI fail. CEA now 118.

Nik Colon

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby Nik Colon » Sat Mar 26, 2016 8:16 pm

Great news!

Blessings617
Posts: 4
Joined: Mon Mar 28, 2016 12:44 am

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby Blessings617 » Tue Mar 29, 2016 8:17 am

Hi Stephen,
I'm very glad to hear your doing well. I hope your health is amazing :) my mom just started this medicine and had some questions about it. I would really likely to speak with you. Thanks for your time




StephenWinsToday wrote:So, although I still haven't found someone else on this trial...I thought I would drop a line here and update a little.

So far I have had two infusions of the PDL-1 inhibitor Atexolizumab, or MPDL3280a, and avastin. The week after my first infusion I had a weeklong fever that reached 104 at its worst. Chilled, tremendous joint pain, sweats...it was a real good time. I was in the hospital for about 4 days and had every test ran on me possible. No signs of infection anywhere. It was chalked up to an immune response to the medicine. It was suggested that my immune system was probably recognizing the cancer and going to war. Sweet. I'll take that!

The second infusion left me slightly tired and very close to nauseous for two days. Then...nothing. I felt wonderful. The tumor pain I was having on my right side was completely gone. My back pain was gone. I hadn't felt that well in a very long time...thank God I happened to have a trip to Mexico planned during this time. The trip went off without a hiccup! Then I broke out in a rash. It covered my torso in small white spots...thankfully the rash wasn't itchy. After three days, it was gone. Was it anothe immune response? Who knows.

I had my first scan today. I'm responding to the drug. Wow...sometimes you want something so bad...then when you get it, you aren't even sure how to feel. My tumor measured 45x32mm a month and a half ago...now it's 37x25mm. The sattelite nodules are shrinking and disappearing. My onc actually said, "we have gained control of this. Which is nice to see."

NICE TO SEE??? Ha! It's AMAZING. Thank you, Doctor!

I go in to meet with him again this Thursday...then I'm due for another infusion. Side effects, beyond the initial fever and rash, have been minimal. Some diarrhea, some tiredness, sandy eyes....that's about it. I feel physically strong, I'm eating everything in sight, and I finally feel.....well. I have a sense of wellness. Finally.

Feel free to ask anything! I heard this drug just had amazing results with bladder cancer and now the drug is trying to get FDA approval by the end of the year. You can google Atezolizumab for more news. This drug has been found to work mainly on those with msi-high tumors. So lynch syndrome people, like myself, have a better chance at responding...but some sporadic CrCs are msi-go as well...I believe around 10% are. I hope this gave you all some insight on this trial and where immunotherapy is heading. I was terrified to enter this trial...but I'm so glad I did. I hope my experience can act as building blocks for future warriors.

Fight on!

Blessings617
Posts: 4
Joined: Mon Mar 28, 2016 12:44 am

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby Blessings617 » Tue Mar 29, 2016 8:22 am

Praise God.. Looking forward to talking to you as my mom started this medicine and we have lots of questions.
StephenWinsToday wrote:Had another scan today.

I am still considered stable with a slight decrease in the primary tumor and slight decrease in the nodules. I'll take it!

Atezolizumab has been a literal life safer!

StephenWinsToday
Posts: 39
Joined: Mon Jun 22, 2015 12:08 pm
Facebook Username: Stephen Savage-Estrada

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby StephenWinsToday » Tue Mar 29, 2016 6:59 pm

Feel free to send me a private message!


Blessings617 wrote:Praise God.. Looking forward to talking to you as my mom started this medicine and we have lots of questions.
StephenWinsToday wrote:Had another scan today.

I am still considered stable with a slight decrease in the primary tumor and slight decrease in the nodules. I'll take it!

Atezolizumab has been a literal life safer!
7/15 DX'd at age 28 w/stage 4 crc. Met to mesentery. Also lynch+
7/15 right hemicolectomy
8/15 started 12 rounds FOLFOX.
2/15 Nanoknife. Gallbladder removal. resections. Complications landed me in ICU for 1 week. 8 blood transfusions.
5/15 Nanoknife failed. Enrolled in phase 1 trial of MPDL3280a (Atezolizumab) & Avastin.
7/15 CT shows I am responding to trial drug. All tumors and nodules shrinking.
8/15 CT scan shows stability of all nodules and target tumor
10/15 CT scan shows continued stability.

Blessings617
Posts: 4
Joined: Mon Mar 28, 2016 12:44 am

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby Blessings617 » Wed Mar 30, 2016 4:00 pm

Hi Stephen,
This forum is not allowing me to PM you so can you please try to PM me. Your the only person I have ever spoke to that's on the same medicine as my mother . Blessings


StephenWinsToday wrote:So, although I still haven't found someone else on this trial...I thought I would drop a line here and update a little.

So far I have had two infusions of the PDL-1 inhibitor Atexolizumab, or MPDL3280a, and avastin. The week after my first infusion I had a weeklong fever that reached 104 at its worst. Chilled, tremendous joint pain, sweats...it was a real good time. I was in the hospital for about 4 days and had every test ran on me possible. No signs of infection anywhere. It was chalked up to an immune response to the medicine. It was suggested that my immune system was probably recognizing the cancer and going to war. Sweet. I'll take that!

The second infusion left me slightly tired and very close to nauseous for two days. Then...nothing. I felt wonderful. The tumor pain I was having on my right side was completely gone. My back pain was gone. I hadn't felt that well in a very long time...thank God I happened to have a trip to Mexico planned during this time. The trip went off without a hiccup! Then I broke out in a rash. It covered my torso in small white spots...thankfully the rash wasn't itchy. After three days, it was gone. Was it anothe immune response? Who knows.

I had my first scan today. I'm responding to the drug. Wow...sometimes you want something so bad...then when you get it, you aren't even sure how to feel. My tumor measured 45x32mm a month and a half ago...now it's 37x25mm. The sattelite nodules are shrinking and disappearing. My onc actually said, "we have gained control of this. Which is nice to see."

NICE TO SEE??? Ha! It's AMAZING. Thank you, Doctor!

I go in to meet with him again this Thursday...then I'm due for another infusion. Side effects, beyond the initial fever and rash, have been minimal. Some diarrhea, some tiredness, sandy eyes....that's about it. I feel physically strong, I'm eating everything in sight, and I finally feel.....well. I have a sense of wellness. Finally.

Feel free to ask anything! I heard this drug just had amazing results with bladder cancer and now the drug is trying to get FDA approval by the end of the year. You can google Atezolizumab for more news. This drug has been found to work mainly on those with msi-high tumors. So lynch syndrome people, like myself, have a better chance at responding...but some sporadic CrCs are msi-go as well...I believe around 10% are. I hope this gave you all some insight on this trial and where immunotherapy is heading. I was terrified to enter this trial...but I'm so glad I did. I hope my experience can act as building blocks for future warriors.

Fight on!

Blessings617
Posts: 4
Joined: Mon Mar 28, 2016 12:44 am

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby Blessings617 » Wed Mar 30, 2016 4:08 pm

If you cannot PM Me feel free to text me six wun seven seven eight four four wun nine two

StephenWinsToday
Posts: 39
Joined: Mon Jun 22, 2015 12:08 pm
Facebook Username: Stephen Savage-Estrada

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby StephenWinsToday » Fri May 06, 2016 10:46 am

Had another scan yesterday. I'm getting ready to hit the one year mark with Atezolizumab! For the first time, I had a major allergic reaction to the contrast for the ct scan, so the morning got off to a rough start. However, it was totally worth it. After months of stability, my tumor appears to have shrunk some more.

Last scan: 37mm x 30mm
CEA: 2.2

Yesterday's scan: 31mm x 27mm
CEA: 1.5

They are advising that the borders of the tumor and an organ are ill defined, so the ct write up said the measurements may not be totally accurate...but with the decreasing CEA (even though it's never been a good indicator), AND the decrease in size...I'm gonna call it a win. Hopefully this is the start of a shrinking trend.

I've been feeling so healthy lately...healthier than ever. I'm working more hours, planning more trips, working out more...life is good.
7/15 DX'd at age 28 w/stage 4 crc. Met to mesentery. Also lynch+
7/15 right hemicolectomy
8/15 started 12 rounds FOLFOX.
2/15 Nanoknife. Gallbladder removal. resections. Complications landed me in ICU for 1 week. 8 blood transfusions.
5/15 Nanoknife failed. Enrolled in phase 1 trial of MPDL3280a (Atezolizumab) & Avastin.
7/15 CT shows I am responding to trial drug. All tumors and nodules shrinking.
8/15 CT scan shows stability of all nodules and target tumor
10/15 CT scan shows continued stability.

testing765
Posts: 324
Joined: Tue Aug 19, 2014 9:41 am

Re: atezolizumab (Mpdl3280a)& avastin phase 1 trial update

Postby testing765 » Fri May 06, 2016 12:13 pm

I am happy to hear your good news, it is quite encouraging.
male-age 44 at diagnosis
8/14-clnscopy
8/14-CT scan,no mets
9/14-left colectomy,CEA 2.2 before surgery
pT2pN2bpM0
3 cm tumor in dscnding colon
7/23 pos LNs
low grade MSI stable
10/14-start folfox
1/15-CT & PET scan and sigmdoscopy- no mets
3/15-finish folfox
9/15- clnscopy- 3 polyps removed
10/15- CT scan, NED
10/16- CT scan, NED, CEA 1.6
10/17- clnscopy- 4 polyps removed, CT scan NED, CEA 1.8
10/14 1.9; 4/15 2.8; 5/15 2.4; 9/15 2.8; 12/15 3.1; 1/16 3.0; 4/16 2.5; 7/16 2.5; 10/16 1.6; 1/17 1.9


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