I live in Norway, where it is more common to use FLOX than FOLFOX as adjuvant therapy for crc. The main advantage with FLOX is no pump, no port.
If anyone is interested, here is a link to a paper discussing pro's and con's with both regimens.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588473/
FLOX vs FOLFOX
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tigerpaw
- Posts: 57
- Joined: Sat Jun 20, 2015 1:34 pm
- Facebook Username: kristin.lossius
- Location: Norway
FLOX vs FOLFOX
63y female
dx July 13 resection of primary in sigmoid colon
Stage 3B cc, T3N1M0
KRAS mutant, codon 12/13, MSS
FLOX (FLV infusion 2 consecutive days + oxi) August 2013. Oxi stopped after 8tx
clear CT 6/14
peri mets + lung met 12/14
1/15 HIPEC
3/15 Lung resection
8/15 Subcutaneous met in midline abdomen-resected
8/15 Two lung nodules, observation, no chemo
2/17 enlarged lymph nodes hilus and mediastinum
5-8/17 FLV + Avastin
3/18 radiation to mediastinal and hilar lymph nodes
dx July 13 resection of primary in sigmoid colon
Stage 3B cc, T3N1M0
KRAS mutant, codon 12/13, MSS
FLOX (FLV infusion 2 consecutive days + oxi) August 2013. Oxi stopped after 8tx
clear CT 6/14
peri mets + lung met 12/14
1/15 HIPEC
3/15 Lung resection
8/15 Subcutaneous met in midline abdomen-resected
8/15 Two lung nodules, observation, no chemo
2/17 enlarged lymph nodes hilus and mediastinum
5-8/17 FLV + Avastin
3/18 radiation to mediastinal and hilar lymph nodes
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Nik Colon
Re: FLOX vs FOLFOX
Sorry, I didn't read, but one could do Xelox and not do port if they wished as Xeloda is the pill form of 5fu and could do oxi via iv. I prefer my port as I have crappy veins anyway. Not sure if that's the same or not.
Re: FLOX vs FOLFOX
My partner started on FOLFOX but went into heart failure after the first 24 hours on the pump so they switched her to FLOX. Only difference between the two is one single "push" of 5FU rather than 36 hours of pump of 5FU (so much less 5FU in total). But she still had a port and received both the Oxaliplatin and the 5 FU through the port. The FLOX has been very effective, based on the PET results.
Partner of L
2/2015: Dx @ 41 yrs rectal cancer T3,N2,M1a (Stage IVa, mets in pelvic and abdominal lymph nodes)
KRAS mutant
3/16/15: Start first treatment: FOLFOX
3/19/15: Heart failure
4/6/15: Switch to FLOX
5/15/15: PET/CT: reduction of main tumor & 4 of 8 malig lymph nodes.
Rx: 2 more chemo
7/20/15 L starts treatment arm of immune-stimulant trial: interferon, Celebrex & rintatolimod for 5 days, then resection of rectal tumor & all lymph nodes in pelvis, peri-rectal & abdomen.
2/2015: Dx @ 41 yrs rectal cancer T3,N2,M1a (Stage IVa, mets in pelvic and abdominal lymph nodes)
KRAS mutant
3/16/15: Start first treatment: FOLFOX
3/19/15: Heart failure
4/6/15: Switch to FLOX
5/15/15: PET/CT: reduction of main tumor & 4 of 8 malig lymph nodes.
Rx: 2 more chemo
7/20/15 L starts treatment arm of immune-stimulant trial: interferon, Celebrex & rintatolimod for 5 days, then resection of rectal tumor & all lymph nodes in pelvis, peri-rectal & abdomen.
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chemo sabe
- Posts: 444
- Joined: Fri Mar 09, 2012 9:01 pm
Re: FLOX vs FOLFOX
I would not advise doing multiple infusions of Oxaliplatin without a port. Not sure why you would. There is no free lunch with chemo.
64 year old male
Diagnosed Stage 3 Rectal Cancer - T3N1M0 - Oct 2011
28 radiation treatments with xeloda
Colon resection with ileostomy Feb 2012
8 Rounds of Xelox completed Sept 2012
Ileostomy reversal surgery Oct 2012
Incisional Hernia Repair Nov 2013
Diagnosed Stage 3 Rectal Cancer - T3N1M0 - Oct 2011
28 radiation treatments with xeloda
Colon resection with ileostomy Feb 2012
8 Rounds of Xelox completed Sept 2012
Ileostomy reversal surgery Oct 2012
Incisional Hernia Repair Nov 2013
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