4 Diifferent Subtypes of CRC Identified

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joe7777777
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Joined: Sat Feb 28, 2015 12:48 pm

4 Diifferent Subtypes of CRC Identified

Postby joe7777777 » Mon May 18, 2015 6:47 pm

Four different Subtypes of Colon Cancer have been Identified each requiring a different form of treatment.

Genetic screening is often needed to know which type of CRC you have

http://www.onclive.com/web-exclusives/T ... tal-Cancer

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vilca11
Posts: 730
Joined: Fri Feb 14, 2014 11:19 am
Location: Moscow, Russia; Baltimore, USA 1992; Vilcabamba, Ecuador 2012

Re: 4 Diifferent Subtypes of CRC Identified

Postby vilca11 » Mon May 18, 2015 7:26 pm

That is darn important!!!! Thanks for posting, Joe!
Vilca
11/2005 CC stage 1, F,50yo@dx
Mod dif adenocar, MSS, APC, TP53, CEAs1.6-4.8
1/12 1met liver@Vena Cava, RFA, 3oxi,11 5FU
8/13 2 mets same place,SBRT
4/14 2 Xeliri+Avastin
5/14 Nano Knife liver same 2 mets
6/14 2 Xeliri, ADAPT
4/15 PET, 2 same mets,Cryo Liver
5/15 MJ Oil, Herbs, Suppl, ADAPT
10/15 PET, same area, doubled in size, high SUV
10/15 RH, HAI, visceral involv., no LN
2/16 red FF, 50% red dose FUDR, CEA trends up
3/16 CT, PET, MRI L.Lobe all in small tumors
4/16 No acceptable options, going home

rp1954
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Joined: Mon Jun 13, 2011 1:13 am

Re: 4 Diifferent Subtypes of CRC Identified

Postby rp1954 » Mon May 18, 2015 8:24 pm

It would be useful if they would cross correlate their subtypes with older, more familiar marker combinations like CEA, CA19-9, CA125, CA72-4, LDH.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper chemo to almost nothing mid 2018, IV C-->2021. Now supplements

jvaime21
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Facebook Username: alpha21_2003

Re: 4 Diifferent Subtypes of CRC Identified

Postby jvaime21 » Mon May 18, 2015 11:35 pm

Thanks for this...

Retchel
wife of Stg 4 SRC
Diag.'12-2013(rd+Xeloda+oxi)
04/16/14 Clear CT-
8/25/14Kidney blockd nepro.
Rec. lung 1 enlrg. Abdomen
Inoperable/incurable /Chemo for life
11/21/14 Xeloda+Irinetocan 6x
hoping for a bright sunny day

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: 4 Diifferent Subtypes of CRC Identified

Postby DK37 » Mon May 18, 2015 11:51 pm

Thanks for posting Joe!!

I'm going to cross-post the below recent sym004 post here, since sym004 was discussed in Joe's link:

-DK

Promising new trial results were just published for these patients:
- KRAS-wt
-Patients who initially responded to an EGFR inhibitor (e.g. cetuximab) but became resistant

"Sym004" is a next generation anti-EGFR monoclonal antibody. It is binds differently to EGFR than cetuximab. For patients who initially responded to cetuximab (i.e. patients whose tumors are intrinsically responsive to anti-EGFR therapy) went onto this trial after they became resistant to cetuximab. When dosed with sym004, 67% responded to the new drug (44% experienced tumor shrinkage and another 23% had stable disease). Side effects were similar to Cetuximab (e.g. on-target skin rash) The duration of response was modest (months) but my personal feeling is that I would gladly accept extra months from a tolerable drug that not only allowed more quality time with my kids but also allow more months of immunotherapy research to proceed...

This was a small trial (39 patients were dosed during dose expansion following dose escalation) - but the results were consistent with what you would expect scientifically so I think probably the same data will roughly be seen in the current confirmatory Phase 2 trial.

Phase Clinical Trial results (this is the current link for pre-print, if it stops working, let me know & I'll update to the finalized link):
http://cancerdiscovery.aacrjournals.org ... l.pdf+html

Phase 2 confirmatory trial in progress in many locations (randomized versus chemo):
https://clinicaltrials.gov/ct2/show/NCT ... 004&rank=1
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List


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