New Pilot Clinical Trial Results for BRAF-mut Stage IV CRC

Please feel free to read, share your thoughts, your stories and connect with others!
User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

New Pilot Clinical Trial Results for BRAF-mut Stage IV CRC

Postby DK37 » Mon Mar 16, 2015 2:59 pm

For the BRAF-mut CRC members of this site, I wanted to draw your attention to a recent pilot clinical trial publication (Sloan-Kettering) which showed clinical activity in 10 out of 12 patients by co-dosing the BRAF inhibitor vemurafenib & the anti-EGFR antibody panitumumab. It is a very new publication, so your Onc might not be aware of it yet - I suggest bringing it to his/her attention for discussion.

Citation: Rona Yaeger et al. "Pilot Trial of Combined BRAF and EGFR Inhibition in BRAF-Mutant Metastatic Colorectal Cancer Patients" Clinical Cancer Research (2015)
Hyperlink: http://clincancerres.aacrjournals.org/c ... l.pdf+html

Unlike in BRAF-mut melanoma, single agent BRAF inhibitors have not demonstrated much single agent activity in BRAF-mut CRC. The multiple parallel clinical trial drug combination studies are starting to show progress.

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”



Who is online

Users browsing this forum: No registered users and 28 guests