PD-1 Inhibitors?

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testing765
Posts: 324
Joined: Tue Aug 19, 2014 9:41 am

PD-1 Inhibitors?

Postby testing765 » Mon Mar 02, 2015 3:00 pm

Hi. I just got back from a presentation that my oncologist gave on behalf of a local cancer support group. He mentioned that PD-1 inhibitors are showing some good results in the area of immunotherapy. Do you know whether a PD-1 inhibitor would work on colon cancer? Do you know of any PD-1 inhibitor trials for colon cancer?

Do people in stage 3 of colon cancer enroll in trials? Or do people wait until they are at stage 4 before they might enroll in a trial study?

As I understand, phase 1 trials test the toxicity of the drug being tested. In the past, a phase 1 trial study could make the patient extremely sick or even kill him/her. One interesting thing the oncologist mentioned was that, today, because potential treatments for cancer are much more specifically and accurately targeted to begin with, entering phase 1 trials today is more promising than enrolling in a phase 1 trial years ago.
male-age 44 at diagnosis
8/14-clnscopy
8/14-CT scan,no mets
9/14-left colectomy,CEA 2.2 before surgery
pT2pN2bpM0
3 cm tumor in dscnding colon
7/23 pos LNs
low grade MSI stable
10/14-start folfox
1/15-CT & PET scan and sigmdoscopy- no mets
3/15-finish folfox
9/15- clnscopy- 3 polyps removed
10/15- CT scan, NED
10/16- CT scan, NED, CEA 1.6
10/17- clnscopy- 4 polyps removed, CT scan NED, CEA 1.8
10/14 1.9; 4/15 2.8; 5/15 2.4; 9/15 2.8; 12/15 3.1; 1/16 3.0; 4/16 2.5; 7/16 2.5; 10/16 1.6; 1/17 1.9

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