radioembolism/chemoembolism

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sjring
Posts: 181
Joined: Mon Jun 30, 2014 3:16 pm
Location: Philadelphia, PA

radioembolism/chemoembolism

Postby sjring » Wed Feb 04, 2015 11:58 pm

Had a conversation with my onc today as we are approaching the end of the current 6 rounds of maintenance chemo in the current cycle to discuss future plans, my maintenance chemo consists of Avastin and 5-FU (infused). Oral meds are not an option, as I had gastric bypass 8 years ago and don't have the upper GI tract to properly absorb it.

She would like to "give me a break from the systemic chemo" and suggested sending me for a consult for radioembolism or chemoembolism (she did not make a preference). I have no remaining visible liver mets on MRI of the original 10+ mets spread throughout both lobes. Though I guess that doesn't prevent there from being other micro mets that are not visible. I've been doing chemo (whether full FOLFOX + Avastin or the maintenance protocol) for about 16 months. The cancer was determined at the original biopsy of being poorly differentiated.

I haven't seen much about these two treatments lately (search shows some discussion back in 2012 on the radioembolism).

If anyone has had either of these treatments, I'd love to have a conversation about the procedures, side effects and effectiveness of what you went through. My next MRI is Feb 27 and onc apt on March 4 so still a month to decide if I want to pursue it or just reduce the frequency of the current maintenance chemo (though when I take advantage of an extra week off, the next treatment tends to knock me harder).

Thanks.
50 YO Husband & father of 2 teenagers.
DX 9/9/13 Stage 4 cc (at age 48)
16 Rounds FOLFOX + Avastin (Oct-13 to May-14)
Maintenance chemo - Avastin & 5-FU infusions (Jun-14 to Jul-15)
Jul-15: Mets to lymph nodes, resuming FOLFOX
Sep-15: MRI showed stability, back to maintenance chemo.

sdp
Posts: 128
Joined: Tue Apr 03, 2012 2:34 pm
Facebook Username: Shitul patel
Location: Mumbai , India

Re: radioembolism/chemoembolism

Postby sdp » Thu Feb 05, 2015 2:01 am

Chemo embolisation is also called TACE
RADIO embolisation is called SIRT.
I Had TACE in November 2014 followed by ablation.
Next scan two months later showed same spots of same size on Ct-pet and now I just had a SIRT Procedure day before.
So I guess tace and ablation was not very successful on me.
The next scan is 2 months away to find the ultimate effect of the current procedure.

Few minor side effects of tace and ablation - resolved within a week - so far not much side effect of sirt - meds seem to be taking care of it .
Dx sig CC/ liver mets stg4 dec/11
10 cyc FOLFOX+Erb
Resect CC And Liver July-Aug/12
2 cyc - FOLFOX+Erb
Erb only -Nov/12-mar/13
iRE to 2 liver met Oct 13
2nd recur Mar 14
Liver resect April '14
3rd recur -july '14
Microwave ablation-2 liver met- July '14

sjring
Posts: 181
Joined: Mon Jun 30, 2014 3:16 pm
Location: Philadelphia, PA

Re: radioembolism/chemoembolism

Postby sjring » Thu Feb 05, 2015 12:43 pm

sdp,

Thanks for that. One additional question, for the infusion procedure, were you awake under a local anesthetic or asleep/twilighted?
50 YO Husband & father of 2 teenagers.
DX 9/9/13 Stage 4 cc (at age 48)
16 Rounds FOLFOX + Avastin (Oct-13 to May-14)
Maintenance chemo - Avastin & 5-FU infusions (Jun-14 to Jul-15)
Jul-15: Mets to lymph nodes, resuming FOLFOX
Sep-15: MRI showed stability, back to maintenance chemo.

sdp
Posts: 128
Joined: Tue Apr 03, 2012 2:34 pm
Facebook Username: Shitul patel
Location: Mumbai , India

Re: radioembolism/chemoembolism

Postby sdp » Thu Feb 05, 2015 2:22 pm

For the TACE and SIRT - local anaesthesia and some mild sedative but awake .

For any ablation it is general anaesthesia.
Dx sig CC/ liver mets stg4 dec/11
10 cyc FOLFOX+Erb
Resect CC And Liver July-Aug/12
2 cyc - FOLFOX+Erb
Erb only -Nov/12-mar/13
iRE to 2 liver met Oct 13
2nd recur Mar 14
Liver resect April '14
3rd recur -july '14
Microwave ablation-2 liver met- July '14


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