Higher Vitamin D levels and colorectal cancer survival

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dianetavegia
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Re: Higher Vitamin D levels and colorectal cancer survival

Postby dianetavegia » Fri Jan 16, 2015 9:50 am

Curious, my first D3 reading was 19 and I live in the deep south. Took 2,000 IU's and got it up to 37 so tried 6,000 IU and got it to 100 - 101 ish. When I first started it 5 1/2 years ago my onc said 'you're wasting your money'. Now he says 'You ARE taking Vit D3, right? That's very important!'
Stage III cc surgery 1/7/09. 12 tx FOLFOX
Stage IV PET = 1.5cm liver met. HR 4/11/12

11 years since dx and 7 3/4 years post liver resection.
Pronounced CURED and discharged by onc

“O Lord my God, I cried out to You, And You healed me.” Psalms 30:2

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Maia
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UPDATED: Higher Vitamin D levels and colorectal cancer survival

Postby Maia » Sun May 31, 2015 1:23 pm

UPDATE May 31th 2015, from onging ASCO 2015 this weekend:

******************************


Higher Vitamin D Levels Linked to Improved Colorectal Cancer Survival

News | May 31, 2015 | ASCO 2015 Colorectal Cancer, Colorectal Cancer, ASCO 2015

Increased concentrations of 25-hydroxyvitamin D were associated with significantly improved overall survival rates in a group of patients with metastatic colorectal cancer treated as part of the phase III Cancer and Leukemia Group B (CALGB)/Southwest Oncology Group (SWOG) 80405 trial.

Kimmie Ng, MD, MPH, of Dana-Farber Cancer Institute, presented results from the trial (abstract 3503), which showed a 7-month improvement in median overall survival among patients with the highest quintile of vitamin D concentrations, at the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting held May 29 to June 2 in Chicago.

Higher vitamin D levels were associated with a significantly improved overall and progression-free survival, and this association persisted across all subgroups examined and even after adjusting for multiple prognostic factors,” Ng said. “A phase II randomized trial to evaluate the impact of vitamin D in conjunction with chemotherapy is currently ongoing.”

According to Ng, previous research has shown that vitamin D inhibits cell proliferation and angiogenesis and induces cell differentiation and apoptosis, as well as having anti-inflammatory effects.
See more at: http://www.cancernetwork.com/asco-2015- ... r-survival


Abstract
Vitamin D status and survival of metastatic colorectal cancer patients: Results from CALGB/SWOG 80405 (Alliance).

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DK37
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Re: Higher Vitamin D levels and colorectal cancer survival

Postby DK37 » Sun May 31, 2015 2:03 pm

I personally believe strongly in this and take Vit D supplements every day...

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
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mstults
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Re: Higher Vitamin D levels and colorectal cancer survival

Postby mstults » Sun May 31, 2015 4:28 pm

My Nephrologist put me on it the first time I saw her. But she only wants me to take enough that my levels are within the normal range. The last check it was 30, the bottom of the range for my lab. I feel I need more.
Male Age 53. Dx CC with numerous liver mets 6/23/12. Colon res 6/24/12. Started folfox 7/24/12. Added avastin 8/27/12. CT 12/27/12 still showing shrink. Took 17 rounds of FOLFOX. Then 5-FU + Avastin. Switched to Irinotecan for 1 yr. CEA rose to >400. Switched to Vectibix 2/18/15. CEA decreasing. Scans show some growth in liver mets. Lung Mets stable to shrinking.

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DK37
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Re: Higher Vitamin D levels and colorectal cancer survival

Postby DK37 » Sun May 31, 2015 4:57 pm

What I personally did was check my blood levels and I take a supplement dose where I hit the top end of the normal range. The test is cheap and my oncologist was on board helping me check-

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

sjring
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Location: Philadelphia, PA

Re: Higher Vitamin D levels and colorectal cancer survival

Postby sjring » Mon Jun 01, 2015 11:13 am

I've mentioned before in addition to the CRC, I had gastric bypass (gbp) back in 2007 (dx with CRC in 2013). One of the vitamins that gbp patients malabsorb is vitamin D, and it wasn't until after the CRC diagnosis that my endocrinologist put me on a high-dose vitamin D therapy to help with my diabeites.

That said, high serum vitamin D levels can also have negative effects, so anyone considering adding vitamin D should do so under a doctor's supervision and monitoring. This is a fat soluable vitamin, and not water soluable (so the body passes excess).

But I'm glad to see more research going into this area.
50 YO Husband & father of 2 teenagers.
DX 9/9/13 Stage 4 cc (at age 48)
16 Rounds FOLFOX + Avastin (Oct-13 to May-14)
Maintenance chemo - Avastin & 5-FU infusions (Jun-14 to Jul-15)
Jul-15: Mets to lymph nodes, resuming FOLFOX
Sep-15: MRI showed stability, back to maintenance chemo.

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exaussie
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Re: Higher Vitamin D levels and colorectal cancer survival

Postby exaussie » Mon Jun 01, 2015 11:18 am

Interesting. My son's level.was 11 at diagnoses. We had my daughter checked for health reasons at that time and she was 9. Pacific northwest is not quite the sun capital of the world! We got a sauna with uv lights and everyone tales 10000 MG a day just to stay in normal range. I wonder if genetics plays a part in absorption of d3
DS 26 yrs old diagnosed 6/13 T3N2aM1b
Resection 6/13
6 rounds chemo folfax
12/13 Fissure
hernia surgery 12/13
5 months break
Maintenance chemo 3/14
Crazy growth. Liver failing. Folfox and vectibex 7-29-14
Chemo failure Hospice 8/26
Left us 8/28

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horizon
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Re: Higher Vitamin D levels and colorectal cancer survival

Postby horizon » Wed Jun 03, 2015 8:35 am

Good to know! My levels were low when I was first diagnosed. I take 4000 UI's a day. I specifically asked my primary physician to measure my vitamin D levels during a physical and my level came back normal.
I'm just a dude who still can't believe he had a resection and went through chemo (currently 9 years NED). Is this real life?

KWT
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Re: Higher Vitamin D levels and colorectal cancer survival

Postby KWT » Wed Jun 03, 2015 8:39 am

D-lightful

I do the same but never checked level

JDinNC
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Re: Higher Vitamin D levels and colorectal cancer survival

Postby JDinNC » Wed Jun 03, 2015 6:24 pm

My doctor put me on Vit D at the time of my diagnose. I was taking 1,000 mg a day when I ran out. So I went to get some more and even though I reached for 1,000 mg. It wasn't until after a month of taking them that I realized they were 5,000 mg. 35,0000 a week, I swear I thought I was going to die!! I never said anything to my doctor about what happened, I figured my blood work would let her know. She never said a word, I'm back to 1,000 and she has mentioned I should reduce my intake to 500 over these last 6 months. I haven't done it yet...though my readings have been in the 90's
61 y/o female @ DX...........
T3N0M1
6/13 DX- stage 4
Sigmoid colon cancer.
One met to lung
7/13 colon resection
8/13 lung resection
7/17 four years....NED
8/18 five years....NED
MELANOMA
63 y/o @ DX
6/15 stage 2a
7/15 surgery on arm
7/15 NED
4/16 recurrance
5/16 remove metastasis from back
5/16. Started immunotherapy
8/16 discontinue treatment
7/18...PET scan...NED

lpas
Posts: 1010
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Re: Higher Vitamin D levels and colorectal cancer survival

Postby lpas » Wed Jun 03, 2015 8:48 pm

I was taking 6,000IU a day this winter and my level was still only 50. I recently upped it to 7,000IU/daily but am wondering now if I should take even more...
11/14 Dx sigmoid CC @ 45yo
12/14 Colectomy + hysterectomy
Stage IIIB, T3N1bM0, 2/20 nodes, MSS, G2, KRAS(A146T), TP53, SMAD4, ERBB2, CEA 1.0
2/15-7/15 XELOX & celecoxib
2/19 clean scope
11/19 clean CT
Ongoing cimetidine & other targeted supplements
Mom to a 6 & 8yo

JENNJ
Posts: 115
Joined: Tue Feb 17, 2015 8:00 pm

Re: Higher Vitamin D levels and colorectal cancer survival

Postby JENNJ » Sun Jun 14, 2015 10:34 am

My Dads level was 19- his onc referred to it as "critically low". Prescribed 50,000iu per week. Hoping it bumps up quick!!
Katy

PainInTheAss
Posts: 668
Joined: Tue Jul 02, 2013 3:08 am

Re: Higher Vitamin D levels and colorectal cancer survival

Postby PainInTheAss » Sun Jun 14, 2015 5:05 pm

My onc recommended D supplements for post treatment recurrence prevention. I have no idea what my levels were, but I live in Arizona and have to constantly hide from the sun so I doubt mine was low.
47yo single mom of 4 (24, 21, 18, 16) at Dx
6/13 - RC T4b IIIc 5LNs on PET CEA 5.4
8/13 - Finish chemorad
10/13 - APR/hyst+ovaries/perm colostomy 2/12 nodes+
6/14 - Finish Xelox 6 rds
1/15 - CT clear CEA 0.2
10/15 - CT/MRI clear CEA 0.7
4/16 - CT clear
10/16 - CT/MRI clear CEA 0.6
5/17 - PET clear? Follow up MRI to verify inflammation

dontwanttobehere
Posts: 43
Joined: Sat Apr 25, 2015 5:41 pm

Re: Higher Vitamin D levels and colorectal cancer survival

Postby dontwanttobehere » Sun Jun 14, 2015 7:40 pm

How do you get your Vitamin D level checked?
47 y/o; mom to 5,7,16,18 and 20 y/o
4/20/15 had first scope as recommended by OB/gyn due to family history with large mass found at splenic flexure
unable to pass and see the remaining 2/3 of colon
4/22/15 cancer confirmed, MSS, had genetic testing-all negative!
node in lungs, cysts in liver and kidneys ??all benign we hope
5/12/15 left hemicolectomy laprascopically
T3Nb1MX

JENNJ
Posts: 115
Joined: Tue Feb 17, 2015 8:00 pm

Re: Higher Vitamin D levels and colorectal cancer survival

Postby JENNJ » Mon Jun 15, 2015 5:31 am

Dontwanttobehere:
We just had to ask our oncologist and she added it to our pre chemo panel...
Good luck
Katy


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