Higher Vitamin D Levels Linked to Improved Colorectal Cancer Survival
News | May 31, 2015 | ASCO 2015 Colorectal Cancer, Colorectal Cancer, ASCO 2015
Increased concentrations of 25-hydroxyvitamin D were associated with significantly improved overall survival rates in a group of patients with metastatic colorectal cancer treated as part of the phase III Cancer and Leukemia Group B (CALGB)/Southwest Oncology Group (SWOG) 80405 trial.
Kimmie Ng, MD, MPH, of Dana-Farber Cancer Institute, presented results from the trial (abstract 3503), which showed a 7-month improvement in median overall survival among patients with the highest quintile of vitamin D concentrations, at the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting held May 29 to June 2 in Chicago.
“Higher vitamin D levels were associated with a significantly improved overall and progression-free survival, and this association persisted across all subgroups examined and even after adjusting for multiple prognostic factors,” Ng said. “A phase II randomized trial to evaluate the impact of vitamin D in conjunction with chemotherapy is currently ongoing.”
According to Ng, previous research has shown that vitamin D inhibits cell proliferation and angiogenesis and induces cell differentiation and apoptosis, as well as having anti-inflammatory effects.
See more at: http://www.cancernetwork.com/asco-2015- ... r-survival
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