DAS43 wrote::D Very good news today! The tumor in my lungs has remained the same size but is fading. The Dr thinks it may now be scar tissue left by the dead cancer cell. I will come back in 3 months for test. I am so glad that the Lord brought me here for treatment. Thank you to all of you that have kept me in prayer. I ask that you continue to pray for me and all cancer patients hoping for a miracle
DAS43 wrote:NHMike
The great thing about this trial is it doesn't matter what your cancer mutations are. What they do is remove a cancer cell find what tumor infiltrating lymphocytes live in that tumor and they design cells that will attack that tumor type. So genetic makeup of the tumor isn't really important because they're going to engineer the cells they give back to you from the tumor that they take. It is truly individualized medicine
NHMike wrote:For most patients, adoptive cell transfer starts with an operation at the National Cancer Institute. By removing one of your tumors, we are able to find and grow the immune cells that live there, known as tumor-infiltrating lymphocytes or TIL. We will grow and study TIL from your tumor in our labs.
...
With your permission, our referral team may request samples of your tumor to test for certain proteins of interest. For cancers expressing those proteins, patients with certain blood typing (HLA) can be treated without the need for an operation. We perform a large blood collection (called an apheresis) and genetically engineer your white blood cells to recognize those targets.
https://ccr.cancer.gov/sb-faqs
I had thought that NCI was only dealing with folks with KRAS G12D with the HLA-C*0802 or HLA-A*1101 Alleles and maybe G12V in the future. But the text above on their site implies that they will take the cases of folks outside of this relatively small group of people as well. I suspect that they are trying to find other combinations where other Alleles express tumor cells of other kinds gene mutations. If my interpretation is correct, then it should be interesting that they are looking for cures for other mutations and finding them could provide hope for many more people. I do not know if they will find other combinations but I would expect that they would.
If I'm incorrect, please let me know. If there are those in the trial that don't have KRAS G12D or don't have HLA-C*0802 and HLA-A*1101, then that would be evidence that they are working on other mutations which would be exciting.
DAS43 wrote::D Very good news today! The tumor in my lungs has remained the same size but is fading. The Dr thinks it may now be scar tissue left by the dead cancer cell. I will come back in 3 months for test. I am so glad that the Lord brought me here for treatment. Thank you to all of you that have kept me in prayer. I ask that you continue to pray for me and all cancer patients hoping for a miracle
fighter168 wrote:I called again today. The nurse said that there is no resection site on the liver, it is too dangerous to remove a sample within the liver.
rachel2017 wrote:NHMike wrote:For most patients, adoptive cell transfer starts with an operation at the National Cancer Institute. By removing one of your tumors, we are able to find and grow the immune cells that live there, known as tumor-infiltrating lymphocytes or TIL. We will grow and study TIL from your tumor in our labs.
...
With your permission, our referral team may request samples of your tumor to test for certain proteins of interest. For cancers expressing those proteins, patients with certain blood typing (HLA) can be treated without the need for an operation. We perform a large blood collection (called an apheresis) and genetically engineer your white blood cells to recognize those targets.
https://ccr.cancer.gov/sb-faqs
I had thought that NCI was only dealing with folks with KRAS G12D with the HLA-C*0802 or HLA-A*1101 Alleles and maybe G12V in the future. But the text above on their site implies that they will take the cases of folks outside of this relatively small group of people as well. I suspect that they are trying to find other combinations where other Alleles express tumor cells of other kinds gene mutations. If my interpretation is correct, then it should be interesting that they are looking for cures for other mutations and finding them could provide hope for many more people. I do not know if they will find other combinations but I would expect that they would.
If I'm incorrect, please let me know. If there are those in the trial that don't have KRAS G12D or don't have HLA-C*0802 and HLA-A*1101, then that would be evidence that they are working on other mutations which would be exciting.
Hey, Mike, Thanks for your explanation. Now I have better understanding about Dr Jimmy Yang’s trial. My question is my mom have KRAS mutation: Gly12Asp. What kind of mutation is it? Is this differencing from G12D? Thanks in advanced!
Rachel
rachel2017 wrote:The G12D mutation results in an amino acid substitution at position 12 in KRAS, from a glycine (G) to an aspartic acid (D).
https://www.mycancergenome.org/content/ ... r/kras/34/
So yes, G12D.
Thanks a lot! I called NCI and a lady gave me this trial contact information. I was a little bit confused why she didn't give me the information of TIL trial. I thought the TIL trial seems like more established.
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