TIL Immunotherapy at NCI

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: TIL Immunotherapy at NCI

Postby Maia » Sun Jun 18, 2017 7:22 am

Jed, I'm so sorry... Looking for the next strategy and having a secret hope that those TILs are and will be doing some good, even if now it is not apparent.

Lee
Posts: 5602
Joined: Sun Apr 16, 2006 4:09 pm

Re: TIL Immunotherapy at NCI

Postby Lee » Sun Jun 18, 2017 6:44 pm

jdepp wrote:I had a scan and met with my doctors today. Progression everywhere, so I'm now off the trial. Best wishes to DAS43 and everyone. /jdepp


(((Jed)))

Jed, I am so sorry to read this. I hope and pray there are other options out there.

You are in my thoughts and prayers,

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

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Sleen
Posts: 310
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Sun Jun 18, 2017 9:10 pm

I'm very sorry, Jed. I hope you'll find another trial--there's got to be something out there!
<3

Celine
my blog: Cancer Riot

NED since April 2016!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 28 yrs. kids: 22, 19, 15, 11, 9
SE Michigan home schooler, unemployed mechanical engineer, and programmer.

DAS43
Posts: 48
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Thu Jun 29, 2017 12:54 pm

:D very happy today with my visits to NIH. Tumor continues to shrink and is now 38% smaller. The pulmonary embolism is also smaller but unfortunately still there. I will continue to be on a blood thinner for 3 to 6 months. Next visit will be months.
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL
9/17 partial responder to TIL protocol

Lee
Posts: 5602
Joined: Sun Apr 16, 2006 4:09 pm

Re: TIL Immunotherapy at NCI

Postby Lee » Thu Jun 29, 2017 1:25 pm

DAS43 wrote::D very happy today with my visits to NIH. Tumor continues to shrink and is now 38% smaller. The pulmonary embolism is also smaller but unfortunately still there. I will continue to be on a blood thinner for 3 to 6 months. Next visit will be months.


Congratulations on your success. Think that calls for some celebrating.

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

DAS43
Posts: 48
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Thu Jun 29, 2017 1:30 pm

Congratulations on your success. Think that calls for some celebrating.

Lee[/quote]
Yes it does!
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL
9/17 partial responder to TIL protocol

sdino
Posts: 56
Joined: Tue Mar 28, 2017 5:32 pm

Re: TIL Immunotherapy at NCI

Postby sdino » Thu Jun 29, 2017 4:05 pm

Das43, can u supply more info ? Are u MSS/MSI, or kras mutant or not ? A little morphology would help us all.
Caregiver for Wife 52 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: Bilateral ranging 4mm-1.5cm
MSS, KRAS-mut G12D; TP53
Completed 12 rounds Folfox/Avastin + Oxi 11/16 to 5/17, 8/17 Start Xeloda + Avastin
CT Scans: 5/17 colon & lung met shrinkage,11/17 and 1/18 slight progression lungs/colon; 5/18 stable lungs/colon
NCI YOUNGER TIL Trial NCT03412877 - 1/18 VATs lung surgery 2 mets wedge resect
CEA: 16 - 11/16; 0.6 - 5/17; 3.0 - 11/17; 4.4 - 1/18; 5.7 - 2/18; 4.9 - 3/18, 4.0 - 5/18

DAS43
Posts: 48
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Thu Jun 29, 2017 4:19 pm

sdino wrote:Das43, can u supply more info ? Are u MSS/MSI, or kras mutant or not ? A little morphology would help us all.


I know that I am kras wild type and mss. Unfortunately that is all I know.
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL
9/17 partial responder to TIL protocol

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Sleen
Posts: 310
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Thu Jun 29, 2017 8:53 pm

Way to go, DAS!!! That's fantastic news.
Got any scoop on the new immunotherapy fellows? I heard the new ones rotated in this week. :)

Celine
my blog: Cancer Riot

NED since April 2016!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 28 yrs. kids: 22, 19, 15, 11, 9
SE Michigan home schooler, unemployed mechanical engineer, and programmer.

DAS43
Posts: 48
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Sat Jul 01, 2017 6:04 am

Sleen wrote:Way to go, DAS!!! That's fantastic news.
Got any scoop on the new immunotherapy fellows? I heard the new ones rotated in this week. :)

Celine


New fellows start Monday. But that is all I know.
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL
9/17 partial responder to TIL protocol

User avatar
Sleen
Posts: 310
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Wed Jul 12, 2017 12:18 pm

We're back from follow-up #12. All good!
They've decided to schedule the next one for SIX MONTHS out. This is a first for me. We'll see if Dr. Rosenberg lets the order stand (he vetoed it last time it was suggested).

My clinic visit was one of the shortest ever, which is OK by me ;)

Celine
my blog: Cancer Riot

NED since April 2016!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 28 yrs. kids: 22, 19, 15, 11, 9
SE Michigan home schooler, unemployed mechanical engineer, and programmer.

DebZ
Posts: 80
Joined: Fri Nov 14, 2014 9:01 pm
Facebook Username: Bulc

Re: TIL Immunotherapy at NCI

Postby DebZ » Wed Jul 12, 2017 2:05 pm

I'm so happy for you, Celine!! What a walking miracle you are. I have bilateral lung mets and just failed Folfiri. At this point I'm going to start looking at the trials. Your blog is so incredible helpful to me. Thank you for taking the time to keep us all up to date.
48 @ diagnosis Sept 2014
MSS; Kras mutant G12D
Oct 2014: right hemicolectomy
Dec 2014-May 2015: Folfox
June 2015: clean scans
Sept 2015: scans reveal ovarian mass and liver met; Folfiri
Jan 2016: liver wedge resection and hysterectomy
April 2016: multiple lung mets; Folfiri+Avastin
June 2017: lung mets growing; switch to Folfox+Avastin
Jan-April 2018: dropped oxali; CEA rising
May 2018: back on Folfox+Avastin, add pulse steroid treatment to get platelet count up (continuously in 50s)

User avatar
Sleen
Posts: 310
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Wed Jul 12, 2017 5:11 pm

Thank you for your kind words, DebZ!

I'm sorry that FOLFIRI didn't work. The world of clinical trials is much, much bigger now than it was just two years ago. I hope that you find many options. If you're MSS, here is a link to the trial finder that two of our own Colon Club members developed.

Celine: EDITED to fix trial finder link.
Last edited by Sleen on Wed Jul 12, 2017 7:45 pm, edited 1 time in total.
my blog: Cancer Riot

NED since April 2016!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 28 yrs. kids: 22, 19, 15, 11, 9
SE Michigan home schooler, unemployed mechanical engineer, and programmer.

User avatar
Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: TIL Immunotherapy at NCI

Postby Maia » Wed Jul 12, 2017 5:52 pm

Celine, I already told you but... SO HAPPPYYYYYYYY!!

That is an old link to the clinical trials finder. Now, Fight Colorectal Cancer did pick up Tom's project and we have a shinny, wonderful web-based finder: Late Stage MSS-CRC Curated trial finder. Here: http://trialfinder.fightcrc.org/

User avatar
Sleen
Posts: 310
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Wed Jul 12, 2017 7:43 pm

Excellent! Thank you for the link.

Celine
my blog: Cancer Riot

NED since April 2016!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 28 yrs. kids: 22, 19, 15, 11, 9
SE Michigan home schooler, unemployed mechanical engineer, and programmer.


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