DAS43 wrote::D
Had my follow up at NIH today. The tumor has shrunk to 49.8% very happy and feel blessed. My next follow up will be in December.
That is so TOTALLY AWESOME!
Keep it up!!
Lee
DAS43 wrote::D
Had my follow up at NIH today. The tumor has shrunk to 49.8% very happy and feel blessed. My next follow up will be in December.
Sleen wrote:pdp497 wrote:On the Clinical Trials website it seems to indicate you only need to have failed one first line treatment but I have seen in other places that you need to have failed on at least 2 treatments first, do you know what the actual criteria is? Also thanks for taking the time to respond going through this process is so difficult and being at the beginning of it it helps to have people willing to give advice and let you know about the process.
Hi pdp!
At the .gov website under "Inclusion Criteria" it says (among other things), "...All patients must be refractory to approved standard systemic therapy. Specifically : Metastatic colorectal patients must have received oxaliplatin or irinotecan."
When I was accepted onto the trial, I had previously only undergone treatment with FOLFOX.
Celine
pdp497 wrote:Sleen wrote:"...All patients must be refractory to approved standard systemic therapy. Specifically : Metastatic colorectal patients must have received oxaliplatin or irinotecan."
When I was accepted onto the trial, I had previously only undergone treatment with FOLFOX.
Celine
Hi Celine,
That is how I read it as well. I will definitely be checking with NIH if the oxaliplatin stops working or the side effects get to be too much. I also wanted to say congrats on your NED status people like you willing to undergo trials like this and achieve lasting success has given me so much hope in the difficult 2 months since my diagnosis. Thank you for taking the time to respond and be a resource to others.
fighter168 wrote:I uploaded all the CT scans and sent over the medical records. But after doctor took a look at my CT images, they think I have all my lesions in my liver, not anywhere else, they do not want to resect a sample from the liver, as it is too risky. Ideally I should have some lesions in the lung or lymph nodes. Is this true? what is your reason to be rejected?
NHMike wrote:How do you determine that you have HLA-C*0802 or HLA-A*1101? Is there a blood test for this? Or do they get it from a tumor sample?
fighter168 wrote:...they do not want to resect a sample from the liver, as it is too risky.
Sleen wrote:NHMike wrote:How do you determine that you have HLA-C*0802 or HLA-A*1101? Is there a blood test for this? Or do they get it from a tumor sample?
Prior to my first in-person screening, NIH sent an HLA Test Kit via Fed Ex. I took it to my local hospital, and a nurse followed the instructions to draw blood, and the hospital shipped it back to NIH using materials included in the kit. At that time, they were testing to see if my HLA matched one of the NY-ESO trials (I was not a match for any of them).
HLA is only a factor in Dr. Yang's trial (They are looking for A*1101, with a KRAS mutation).
Dr. Rosenberg's trial (the one I did--see link in my sig.) can potentially work with any HLA and any mutation, providing you have at least one tumor of sufficient size, and in an easily resectable spot.
Celine
NHMike wrote:fighter168 wrote:I uploaded all the CT scans and sent over the medical records. But after doctor took a look at my CT images, they think I have all my lesions in my liver, not anywhere else, they do not want to resect a sample from the liver, as it is too risky. Ideally I should have some lesions in the lung or lymph nodes. Is this true? what is your reason to be rejected?
Was there a biopsy sample with your original CRC tumor?
Sleen wrote:fighter168 wrote:...they do not want to resect a sample from the liver, as it is too risky.
Who told you that? I would question this statement. I know that they have resected liver tumors for the purpose of growing TIL. It is possible that your particular tumors are in a dangerous location within the liver, however. I would ask for clarification on this point before accepting a rejection. Good luck!
Celine
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