TIL Immunotherapy at NCI

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crazylife
Posts: 213
Joined: Wed Dec 30, 2015 11:29 am

Re: TIL Immunotherapy at NCI

Postby crazylife » Tue May 23, 2017 10:11 pm

Does anyone know if you have to show chemo resistance to qualify for this trial? DH had folfox and finished up last summer. NED for a bit but not has about 5 lung mets.
Wife to DH, 41 years old, diagnosed 11/15
Stage 4, Mod diff, 13/24 LN, 1 liver met
Colon/liver resection at MSK, 11/15
8mm lung met (not confirmed) and enlarged lymph nodes 1/16
12 rounds of folfox (9 with Oxi) 6/16
NED - July 2016
NED - October 2016
3 possible lung mets (watch & see) - March 2016

DAS43
Posts: 31
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Wed May 24, 2017 7:47 am

Jdepp

Please stay positive, some are shrinking! Remember sleen also had a tumor grow and they were able to treat it and she is now ned. I go next Wednesday for a ct scan and a brain MRI. Not sure why they are repeating the brain MRI. This will be the 3rd. They said the last 2 were clear. I thought it was rare for colon to spread to brain. As akways you remain in my prayers
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL

DAS43
Posts: 31
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Wed May 24, 2017 7:54 am

crazylife wrote:Does anyone know if you have to show chemo resistance to qualify for this trial? DH had folfox and finished up last summer. NED for a bit but not has about 5 lung mets.


As long as DH has had oxaliplatin/irretican he can be considered. There has to be at least 2 tumors one must be at least 1cm and be able to be taken out. When I found out I had tumors in the lungs I applied there first before I started chemo. After I was accepted and they removed tumor. I had 6 rounds of chemo to keep tumor in check. Hope this helped
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL

jdepp
Posts: 479
Joined: Sun Sep 28, 2008 7:53 pm

Re: TIL Immunotherapy at NCI

Postby jdepp » Wed May 24, 2017 11:50 am

DAS43,

I don't know why they're giving you another MRI. I had two, but that was all. Good luck next Wednesday.
Colon dx 08 @ 41 Poorly diff. 12+ liver mets, 19/28 LN
Colon rsx /14 x Folfox-Erbitux 08-09
PVE / Liver rsx 09
Lung & LN mets 10
Folfiri, Xeloda, Avastin 10-13
Xelox, Erbitux, UFUR, TS-1, Oxi, Lonsurf 14-16
Stivarga & TIL trial 16

Lee
Posts: 4821
Joined: Sun Apr 16, 2006 4:09 pm

Re: TIL Immunotherapy at NCI

Postby Lee » Fri May 26, 2017 6:17 pm

All the best to those of you on this trial.

Celine has had great success and I hope this trial is as successful for those of you in the trenches.

I like AnnClare line,

My fellow ass kickers,

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

User avatar
Sleen
Posts: 286
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Fri May 26, 2017 7:50 pm

JDepp and DAS: I'm pulling for you both!

regarding brain MRI: I get them every-other (scan) visit.

Celine
my blog: Cancer Riot

12 mo. f/u: NED!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 26 yrs. kids: 21, 18, 14, 10, 8
SE Michigan home schooler, mechanical engineer, and programmer.

DAS43
Posts: 31
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Thu Jun 01, 2017 5:09 pm

My ct scan shows 37% tumor shrinkage! Very happy with that. I however have a small pulmonary embolism. They started me on xalto and I will go back in a month for another scan. No brain MRI said that was mis scheduling. So that made me happy. A little worried about the pulmonary embolism but I have no symptoms so I figure take the meds and don't worry till I have a symptom lol. Something of interest my fellow said that I was the last to get Keytruda.
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL

User avatar
Maia
Posts: 2328
Joined: Fri Aug 24, 2012 8:00 am

Re: TIL Immunotherapy at NCI

Postby Maia » Thu Jun 01, 2017 5:33 pm

DAS43 wrote:My ct scan shows 37% tumor shrinkage!

Yes!!!!!!
I hope the pulmonary embolism gets resolved soon!
What do you mean with the last on getting Keytruda? Are they changing the protocol?
Oh, hope you update your fellows in other venues with your good news... *hint* :)

DAS43
Posts: 31
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Thu Jun 01, 2017 6:47 pm

Maia wrote:
DAS43 wrote:My ct scan shows 37% tumor shrinkage!

Yes!!!!!!
I hope the pulmonary embolism gets resolved soon!
What do you mean with the last on getting Keytruda? Are they changing the protocol?
Oh, hope you update your fellows in other venues with your good news... *hint* :)


Yes they are changing the protocol slightly to exclude the Keytruda
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL

jdepp
Posts: 479
Joined: Sun Sep 28, 2008 7:53 pm

Re: TIL Immunotherapy at NCI

Postby jdepp » Thu Jun 01, 2017 9:39 pm

Wow, great news that the TIL are working so well! May they continue until they wipe out your cancer!

:)
Colon dx 08 @ 41 Poorly diff. 12+ liver mets, 19/28 LN
Colon rsx /14 x Folfox-Erbitux 08-09
PVE / Liver rsx 09
Lung & LN mets 10
Folfiri, Xeloda, Avastin 10-13
Xelox, Erbitux, UFUR, TS-1, Oxi, Lonsurf 14-16
Stivarga & TIL trial 16

User avatar
Sleen
Posts: 286
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Thu Jun 01, 2017 11:12 pm

DAS43 wrote:My ct scan shows 37% tumor shrinkage!


OUTSTANDING! Congratulations :) :) :)

Celine
my blog: Cancer Riot

12 mo. f/u: NED!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 26 yrs. kids: 21, 18, 14, 10, 8
SE Michigan home schooler, mechanical engineer, and programmer.

Lee
Posts: 4821
Joined: Sun Apr 16, 2006 4:09 pm

Re: TIL Immunotherapy at NCI

Postby Lee » Sat Jun 03, 2017 2:19 pm

DAS43 wrote:My ct scan shows 37% tumor shrinkage! Very happy with that. I however have a small pulmonary embolism. They started me on xalto and I will go back in a month for another scan. No brain MRI said that was mis scheduling. So that made me happy. A little worried about the pulmonary embolism but I have no symptoms so I figure take the meds and don't worry till I have a symptom lol. Something of interest my fellow said that I was the last to get Keytruda.


Sorry about the pulmonary embolism, hope it gets resolved soon, butt congratulations on the 37% tumor shrinkage. That is awesome news.

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

User avatar
LPL
Posts: 223
Joined: Fri Apr 22, 2016 12:49 am
Location: Europe

Re: TIL Immunotherapy at NCI

Postby LPL » Sat Jun 03, 2017 5:31 pm

Hi DAS43,
Wonderful to hear your news about what is happening with your tumor :) So Happy for you !
You wrote about being a little worried about a small Pulmonary embolism. Having been worried myself about a blood clot in my leg, I found and read a Blog about PE. If you are interested, if you get some symptoms, - this is the Blog:
What recovery from a pulmonary embolism looks like https://bloodclotrecovery.net/what-reco ... ooks-like/
DH @ 65 DX 4/11/16 CC recto-sigmoid junction
Adenocarcenoma pt 35x15x9mm G3(biopsi) G1(surgical)
Mets 3 Liver resectable
T4aN1bM1a Stage IVa 2/9 LN
MSS, KRAS-mut G13D
CEA & CA19-9: 5/18 2.5 78 8/17 1.4 48 2/14/17 1.8 29
4 Folfox 6/15-7/30 (b4 liver surgery) 8 after
CT: 8/8 no change 3/27/17 NED for now :D
:!: Steroid induced hyperglycemia dx after 3chemo .. hospitalized, insulin -> Metformin
Surgeries (open):
3/18 Emergency colostomy 5/23 Primary+gallbl+colostomy reversal (+port) 9/01 Liver mets

jdepp
Posts: 479
Joined: Sun Sep 28, 2008 7:53 pm

Re: TIL Immunotherapy at NCI

Postby jdepp » Thu Jun 15, 2017 1:59 pm

I had a scan and met with my doctors today. Progression everywhere, so I'm now off the trial. Best wishes to DAS43 and everyone. /jdepp
Colon dx 08 @ 41 Poorly diff. 12+ liver mets, 19/28 LN
Colon rsx /14 x Folfox-Erbitux 08-09
PVE / Liver rsx 09
Lung & LN mets 10
Folfiri, Xeloda, Avastin 10-13
Xelox, Erbitux, UFUR, TS-1, Oxi, Lonsurf 14-16
Stivarga & TIL trial 16

DAS43
Posts: 31
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Sun Jun 18, 2017 6:55 am

jdepp wrote:I had a scan and met with my doctors today. Progression everywhere, so I'm now off the trial. Best wishes to DAS43 and everyone. /jdepp


Jdeep so sorry to read this. Did NIH have any suggestions on what you should try next?
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL


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