TIL Immunotherapy at NCI

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Maia
Posts: 2393
Joined: Fri Aug 24, 2012 8:00 am

Re: TIL Immunotherapy at NCI

Postby Maia » Thu Feb 16, 2017 7:57 am

Hey, Celine's interview with Joan Lunden is on YT now, also: https://www.youtube.com/watch?v=Talj5pIrMLw

I just watched again...Got so happy for Celine and the family that I have to get up from my chair. And later, I could focus better on my hero, super admired scientist (years ago, I called this trial "Rosenberg trial", cfr. the second post in the first page of this thread). I see Dr Rosenberg and I want to take a plane and go and give him a hug. Imagine a whole life,so many years devoted to beat cancer and he starts to see these results. Still, so humble, such a hard worker. Mazal Tov, well done, Steven.

DAS43
Posts: 36
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Wed Feb 22, 2017 1:11 pm

Sending prayers to jdepp. Who should be a NIH starting the process for cell day, according to last post.
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL

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Maia
Posts: 2393
Joined: Fri Aug 24, 2012 8:00 am

Re: TIL Immunotherapy at NCI

Postby Maia » Wed Feb 22, 2017 4:35 pm

Yes!!!! Strong thoughts his way.

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Sleen
Posts: 292
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
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Re: TIL Immunotherapy at NCI

Postby Sleen » Wed Feb 22, 2017 9:15 pm

Good luck to JDepp!!!

Celine
my blog: Cancer Riot

NED for 15 mos. as of July 2017!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 26 yrs. kids: 21, 18, 15, 10, 8
SE Michigan home schooler, mechanical engineer, and programmer.

Pita
Posts: 636
Joined: Wed Feb 10, 2016 3:48 pm
Location: So Calif

Re: TIL Immunotherapy at NCI

Postby Pita » Thu Feb 23, 2017 6:16 am

Please delete.
Last edited by Pita on Thu Mar 23, 2017 1:59 am, edited 1 time in total.
70yo Fem DX: 1/21/2016 RC Stage IV-Nodules lungs
MSS-Kras Wild-Lynch Synd Neg-Lung Biopsy 1/27/16-Port 2/19/16
MRI 7/7/16 Endometrial polyp found, watching LAR 7/19/16, No Ileostomy, Stage ypT3 N1
CT 11/7/16: Most mets stable,1 shrunk,1 new??
CEA Tests: 1/21/16=20, 12/22/16=5.3, 1/20/17=4.8, 2/15/17=6.2
9/20/16-1/24/17 Folfuri & Avastin
#10/10 Done
PET/CT 2/10/16-1/31/17=Some shrunk & growth to 2, Avastin failing ??? :evil:
2/21/17 Folfuri & Avastin

jdepp
Posts: 481
Joined: Sun Sep 28, 2008 7:53 pm

Re: TIL Immunotherapy at NCI

Postby jdepp » Thu Feb 23, 2017 6:54 am

Thanks all. Yes, I'm starting the chemo portion of the trial later today. Having read Akasleen's play-by-play and commentary, I have an idea of what to expect. Best wishes to everyone pursuing every strategy against cancer.
Colon dx 08 @ 41 Poorly diff. 12+ liver mets, 19/28 LN
Colon rsx /14 x Folfox-Erbitux 08-09
PVE / Liver rsx 09
Lung & LN mets 10
Folfiri, Xeloda, Avastin 10-13
Xelox, Erbitux, UFUR, TS-1, Oxi, Lonsurf 14-16
Stivarga & TIL trial 16

Lee
Posts: 4973
Joined: Sun Apr 16, 2006 4:09 pm

Re: TIL Immunotherapy at NCI

Postby Lee » Thu Feb 23, 2017 11:13 am

good luck jdepp

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

DAS43
Posts: 36
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Mon Mar 20, 2017 7:12 pm

I am home from NIH

Just wanted to let everyone know I was released on Saturday. I truly believe I received the best care from them. The chemo is tough. Il2 is worse. The Doctors and nurses do a great job getting you through it. I received 98 billion cells truly amazing. I was only able to handle 4 doses of the IL2. It gave me horrible shakes. I have had patients who have had grandmal seizures. I have a new appreciation for what they feel. ( I know my shakes weren't half as bad as a seizure. ) very tired but happy to be home. Already got lots of love from the grand babies.
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL

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Maia
Posts: 2393
Joined: Fri Aug 24, 2012 8:00 am

Re: TIL Immunotherapy at NCI

Postby Maia » Mon Mar 20, 2017 9:24 pm

So so so happy and hopeful for you, Deb!!! Let's wait for those little powerful players do their wonderful job!!!
Sending strong, best thoughts your way! : )

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Sleen
Posts: 292
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Tue Mar 21, 2017 9:22 am

CONGRATULATIONS, Deb!

Celine
my blog: Cancer Riot

NED for 15 mos. as of July 2017!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 26 yrs. kids: 21, 18, 15, 10, 8
SE Michigan home schooler, mechanical engineer, and programmer.

jdepp
Posts: 481
Joined: Sun Sep 28, 2008 7:53 pm

Re: TIL Immunotherapy at NCI

Postby jdepp » Tue Mar 21, 2017 11:40 am

Welcome back, Deb. I agree with you: the chemo was bad but the IL2 was worse. From my experience, after a few days resting at home, the energy starts to come back fast. It helps that people aren't stealing your blood every day and taking your vital signs every 4 hours :)

Wishing you the best. /jdepp
Colon dx 08 @ 41 Poorly diff. 12+ liver mets, 19/28 LN
Colon rsx /14 x Folfox-Erbitux 08-09
PVE / Liver rsx 09
Lung & LN mets 10
Folfiri, Xeloda, Avastin 10-13
Xelox, Erbitux, UFUR, TS-1, Oxi, Lonsurf 14-16
Stivarga & TIL trial 16

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DH2Sleen
Posts: 61
Joined: Thu Jan 29, 2015 10:10 am

Re: TIL Immunotherapy at NCI

Postby DH2Sleen » Tue Mar 21, 2017 1:31 pm

I'm so happy for both Jed and Deb. Go TILs Go. I can hardly wait to hear about your scans in a few weeks.
DW, Sleen dx 9/2013 @47yo: IIIc T4b N2b MX
09/2013 colectomy
10/2013 - 3/2014 FOLFOX
04/2014 - 6/2014 Rad to bladder
12/2014 +'ve for lung mets, MX becomes M1
03/2015 enter TIL trial @ NIH
07/01/15 Receive 148E9 cells to target K-ras G12D mutation
08/11/15 Reduction=18%, no new tumors
09/15/15 25%
10/20/15 27%; PET -> one hot met
11/24/15 30% all mets shrinking
01/26/16 46% but one suspicious met
03/24/16 46% but one growing
04/07/16 Lung lobectomy NED for the first time

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LPL
Posts: 270
Joined: Fri Apr 22, 2016 12:49 am
Location: Europe

Re: TIL Immunotherapy at NCI

Postby LPL » Tue Mar 21, 2017 4:15 pm

jdepp & DAS43
I hope you two will have fantastic results, just like Sleen :D
You all give so much hope for others !
Wishing you all the best !!! /LPL
DH @ 65 DX 4/11/16 CC recto-sigmoid junction
Adenocarcenoma pt 35x15x9mm G3(biopsi) G1(surgical)
Mets 3 Liver resectable
T4aN1bM1a Stage IVa 2/9 LN
MSS, KRAS-mut G13D
CEA & CA19-9: 5/18 2.5 78 8/17 1.4 48 2/14/17 1.8 29
4 Folfox 6/15-7/30 (b4 liver surgery) 8 after
CT: 8/8 no change 3/27/17 NED for now :D
:!: Steroid induced hyperglycemia dx after 3chemo .. hospitalized, insulin -> Metformin
Surgeries (open):
3/18 Emergency colostomy 5/23 Primary+gallbl+colostomy reversal (+port) 9/01 Liver mets

bobhuang1
Posts: 2
Joined: Sat Apr 08, 2017 11:34 pm
Facebook Username: bobhuang1

Re: TIL Immunotherapy at NCI

Postby bobhuang1 » Sat Apr 08, 2017 11:54 pm

Hello, I found this thread via a Google search and just registered. I have been taking care my wife ever since she was diagnosed with colon cancer on Christmas 2015. Unfortunately after 12 sessions of Folfox and 4 cycles of FOLFIRI+Avastin, the illness still progressed. We applied to this clinical trial by Dr. Rosenberg and we will fly down to Bethesda next week for a "final" screening. My question is, what kind of experience others have during this screening? Any details? And what to expect after the screening in terms of timeline? What can I do as a caretaker to make the whole thing less painful/stressful for my wife? Thanks much!

Bob

Jacques
Posts: 408
Joined: Sun Dec 28, 2014 10:38 am

Re: TIL Immunotherapy at NCI

Postby Jacques » Sun Apr 09, 2017 7:45 am

bobhuang1 wrote:Hello, I found this thread via a Google search and just registered. I have been taking care my wife ever since she was diagnosed with colon cancer on Christmas 2015. Unfortunately after 12 sessions of Folfox and 4 cycles of FOLFIRI+Avastin, the illness still progressed. We applied to this clinical trial by Dr. Rosenberg and we will fly down to Bethesda next week for a "final" screening. My question is, what kind of experience others have during this screening? Any details? And what to after the screening in terms of timeline? What can I do as a caretaker to make the whole thing less painful/stressful for my wife? Thanks much!

Bob

Is this the trial that you mentioned? https://www.clinicaltrials.gov/ct2/show/study/NCT01174121?show_desc=Y#desc
DX(2012): RC
Stage IIc,T4b N0 M0 L0 PN1 H0 D0 P0 I1
LAR
MSI: not tested
Chimio-radiothérapie
Chimiothérapie adjuvante : capécitabine + oxaliplatine
CEA < 1.0,
5 years NED,
End of 6-month follow-ups: 7/2017
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