TIL Immunotherapy at NCI

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Pita
Posts: 636
Joined: Wed Feb 10, 2016 3:48 pm
Location: So Calif

Re: TIL Immunotherapy at NCI

Postby Pita » Mon Feb 06, 2017 1:52 pm

Celine you were wonderful on the Today show today!!! Seeing you, the Doctor and the lab makes it so real compared to reading it.
The one thing I did not know (which I may have missed reading in this post) is that they are using "your" cells for other people. Amazing!!!

If you get the call to come to Hollywood, let me know, I'm close. :lol:

Hugs and prayers... oxo
70yo Fem DX: 1/21/2016 RC Stage IV-Nodules lungs
MSS-Kras Wild-Lynch Synd Neg-Lung Biopsy 1/27/16-Port 2/19/16
MRI 7/7/16 Endometrial polyp found, watching LAR 7/19/16, No Ileostomy, Stage ypT3 N1
CT 11/7/16: Most mets stable,1 shrunk,1 new??
CEA Tests: 1/21/16=20, 12/22/16=5.3, 1/20/17=4.8, 2/15/17=6.2
9/20/16-1/24/17 Folfuri & Avastin
#10/10 Done
PET/CT 2/10/16-1/31/17=Some shrunk & growth to 2, Avastin failing ??? :evil:
2/21/17 Folfuri & Avastin

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DH2Sleen
Posts: 65
Joined: Thu Jan 29, 2015 10:10 am

Re: TIL Immunotherapy at NCI

Postby DH2Sleen » Mon Feb 06, 2017 2:45 pm

Pita wrote:The one thing I did not know (which I may have missed reading in this post) is that they are using "your" cells for other people.


Joan used a little creative license with that one. She said they would use Sleen's cells. What they will actually do is use a virus to transfer the T-Cell Receptor (TCR) from Sleen's cells to other patients' cells. Each patient would get their own cells back, modified to act like Sleen's cells. It is virtually the same thing, and the fact that she has a common mutation means there could be hundreds or even thousands of patients per year that could benefit. NIH is working with Kite Pharma to make this happen, with trials beginning possibly as soon as this year (for a similar TCR). This is call Engineered TCR Adoptive Cell Therapy.
DW, Sleen dx 9/2013 @47yo: IIIc T4b N2b MX
09/2013 colectomy
10/2013 - 3/2014 FOLFOX
04/2014 - 6/2014 Rad to bladder
12/2014 +'ve for lung mets, MX becomes M1
03/2015 enter TIL trial @ NIH
07/01/15 Receive 148E9 cells to target K-ras G12D mutation
08/11/15 Reduction=18%, no new tumors
09/15/15 25%
10/20/15 27%; PET -> one hot met
11/24/15 30% all mets shrinking
01/26/16 46% but one suspicious met
03/24/16 46% but one growing
04/07/16 Lung lobectomy NED for the first time

mariane
Posts: 567
Joined: Sun Sep 13, 2015 6:16 pm

Re: TIL Immunotherapy at NCI

Postby mariane » Mon Feb 06, 2017 6:12 pm

Super exciting news! It may mean cure for all KRAS crc with codon 12 mutation. I thought they would attempt that when I heard about Sleen's amazing Tcells. I was not sure whether they would be able technically to do that. Medicine has made unbelievable progress lately...
mom of 8 years old twins, dx @ 40 with upper rectal cancer, 10+ liver mets in 6/2015, CEA 140
chemo: 8/2015 - 10/2016 - 4xFOLFIRINOX, 2xFOLFOX, 8xFOLFIRI, 10x5FU, HAI pump -12xFUDR
4 surgeries, complete pathological response
CEA<2 since 10/2015
NED since May 2016

I praise God for every day with my family!

lpas
Posts: 984
Joined: Wed Nov 19, 2014 11:11 pm

Re: TIL Immunotherapy at NCI

Postby lpas » Mon Feb 06, 2017 8:52 pm

FYI, here's a link to the video for anyone who missed it. Great job, Sleen!

http://www.today.com/video/war-on-cancer-see-the-latest-groundbreaking-advances-870897219772
11/14: Dx sigmoid CC @ 45yo
12/14: laparoscopic colectomy + hysterectomy
Stage IIIB, T3N1bM0, 2/20 nodes, MSS, G2, KRAS (A146T), TP53, SMAD4, ERBB2, pre-surgical CEA 1.0
2/15 to 7/15: XELOX, celecoxib & many supplements
3/16: Ovarian mass, rt ovary removed. Benign fibroid.
9/16: clean colonoscopy
3/17: clean CT
Post-chemo CEA: 3.0, 2.5, 2.3, 2.0, 1.6, 1.3, 1.8, 2.1, 1.8, 2.0, 1.8, 1.9, 1.7, 1.5, 1.6, 1.5, 1.4, 1.4, 1.3, 1.3, 1.6, 1.6
Mom to a 3 & 5-year-old

Pita
Posts: 636
Joined: Wed Feb 10, 2016 3:48 pm
Location: So Calif

Re: TIL Immunotherapy at NCI

Postby Pita » Tue Feb 07, 2017 8:05 pm

Thank you for the additional information DH2Sleen. It was nice to see you too DH :)

I received an e-mail today from them saying they weren't accepting anyone on active therapy. Not sure what that meant, my last chemo? which was 01/24/17 and no plans for more until I get an answer from one of two trials I've applied for. E-mailed them back so hope to hear in the morning. Not sure why my Onc would say I fit this trial, supposedly he read the sheet over that I gave him. ??
70yo Fem DX: 1/21/2016 RC Stage IV-Nodules lungs
MSS-Kras Wild-Lynch Synd Neg-Lung Biopsy 1/27/16-Port 2/19/16
MRI 7/7/16 Endometrial polyp found, watching LAR 7/19/16, No Ileostomy, Stage ypT3 N1
CT 11/7/16: Most mets stable,1 shrunk,1 new??
CEA Tests: 1/21/16=20, 12/22/16=5.3, 1/20/17=4.8, 2/15/17=6.2
9/20/16-1/24/17 Folfuri & Avastin
#10/10 Done
PET/CT 2/10/16-1/31/17=Some shrunk & growth to 2, Avastin failing ??? :evil:
2/21/17 Folfuri & Avastin

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Sleen
Posts: 295
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Wed Feb 08, 2017 9:39 am

Pita wrote:...weren't accepting anyone on active therapy.


I wonder what that means, too. Please let us know how they respond.
GOOD LUCK!

Celine
my blog: Cancer Riot

NED since April 2016!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 26 yrs. kids: 21, 18, 15, 10, 8
SE Michigan home schooler, mechanical engineer, and programmer.

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CRguy
Posts: 9230
Joined: Sun Feb 10, 2008 6:00 pm

Re: TIL Immunotherapy at NCI

Postby CRguy » Wed Feb 08, 2017 4:03 pm

That is indeed EPIC Celine !!!!!!

continued success to you and may your example help to redouble the efforts to move these personalized protocols forward
for everyone who needs them.

In Harmony my friend
CRguy
Caregiver x 3
Stage IV A rectal cancer/lung met
10 Year survivor
my life is an ongoing NONrandomized UNcontrolled experiment with N=1 !
Review of my Journey so far

Lee
Posts: 5174
Joined: Sun Apr 16, 2006 4:09 pm

Re: TIL Immunotherapy at NCI

Postby Lee » Thu Feb 09, 2017 7:11 pm

CRguy wrote:That is indeed EPIC Celine !!!!!!


Could not have said it better, so totally AWESOME :D

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

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Sleen
Posts: 295
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Thu Feb 09, 2017 10:25 pm

Thanks for the positive feedback on the news story everyone!

Some trivia for you: In the clip that showed me and Patrick (dh2sleen) sitting on a couch looking at his phone, we were texting w/ColonTalk's own Dr. Tom (DK37) :)

Celine
my blog: Cancer Riot

NED since April 2016!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 26 yrs. kids: 21, 18, 15, 10, 8
SE Michigan home schooler, mechanical engineer, and programmer.

Pita
Posts: 636
Joined: Wed Feb 10, 2016 3:48 pm
Location: So Calif

Re: TIL Immunotherapy at NCI

Postby Pita » Fri Feb 10, 2017 8:42 pm

Sleen wrote:
Pita wrote:...weren't accepting anyone on active therapy.


I wonder what that means, too. Please let us know how they respond.
GOOD LUCK!

Celine


I checked off the yes box on active therapy instead of no and that's why they wrote back what they did. Sent a note back and nurse will be calling me within the week. :)
70yo Fem DX: 1/21/2016 RC Stage IV-Nodules lungs
MSS-Kras Wild-Lynch Synd Neg-Lung Biopsy 1/27/16-Port 2/19/16
MRI 7/7/16 Endometrial polyp found, watching LAR 7/19/16, No Ileostomy, Stage ypT3 N1
CT 11/7/16: Most mets stable,1 shrunk,1 new??
CEA Tests: 1/21/16=20, 12/22/16=5.3, 1/20/17=4.8, 2/15/17=6.2
9/20/16-1/24/17 Folfuri & Avastin
#10/10 Done
PET/CT 2/10/16-1/31/17=Some shrunk & growth to 2, Avastin failing ??? :evil:
2/21/17 Folfuri & Avastin

Pita
Posts: 636
Joined: Wed Feb 10, 2016 3:48 pm
Location: So Calif

Re: TIL Immunotherapy at NCI

Postby Pita » Fri Feb 10, 2017 9:32 pm

Sleen wrote:
Pita wrote:...weren't accepting anyone on active therapy.


I wonder what that means, too. Please let us know how they respond.
GOOD LUCK!

Celine


I checked off the yes box on active therapy instead of no and that's why they wrote back what they did. Sent a note back and nurse will be calling me within the week. :)
70yo Fem DX: 1/21/2016 RC Stage IV-Nodules lungs
MSS-Kras Wild-Lynch Synd Neg-Lung Biopsy 1/27/16-Port 2/19/16
MRI 7/7/16 Endometrial polyp found, watching LAR 7/19/16, No Ileostomy, Stage ypT3 N1
CT 11/7/16: Most mets stable,1 shrunk,1 new??
CEA Tests: 1/21/16=20, 12/22/16=5.3, 1/20/17=4.8, 2/15/17=6.2
9/20/16-1/24/17 Folfuri & Avastin
#10/10 Done
PET/CT 2/10/16-1/31/17=Some shrunk & growth to 2, Avastin failing ??? :evil:
2/21/17 Folfuri & Avastin

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Sleen
Posts: 295
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Sat Feb 11, 2017 7:26 pm

whew!
I was hoping it was something simple like that.
YAY!

Celine
my blog: Cancer Riot

NED since April 2016!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 26 yrs. kids: 21, 18, 15, 10, 8
SE Michigan home schooler, mechanical engineer, and programmer.

DAS43
Posts: 38
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Wed Feb 15, 2017 10:57 am

I just received a call from NIH. They have scheduled me to be admitted on Feb 27th. My cell day will be March 9th. I was expecting to have more notice than this, but ok I can roll with it. Excited and scared at the same time
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL
9/17 partial responder to TIL protocol

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Maia
Posts: 2436
Joined: Fri Aug 24, 2012 8:00 am

Re: TIL Immunotherapy at NCI

Postby Maia » Wed Feb 15, 2017 12:01 pm

Hoorrrayyy!! :)

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Sleen
Posts: 295
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Wed Feb 15, 2017 3:48 pm

Way to go, Deb! Enjoy your stay on 3NW :)
HOW EXCITING!

Celine
my blog: Cancer Riot

NED since April 2016!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 26 yrs. kids: 21, 18, 15, 10, 8
SE Michigan home schooler, mechanical engineer, and programmer.


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