TIL Immunotherapy at NCI

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Maia
Posts: 2214
Joined: Fri Aug 24, 2012 8:00 am

Re: TIL Immunotherapy at NCI

Postby Maia » Sun Jan 08, 2017 9:14 pm

Such an important post! All what you need about that trial, to start, is there. Thank you, Celine!! :)

SO HAPPY about your ongoing wellness!!!!!!

DAS43
Posts: 24
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Mon Jan 23, 2017 3:41 pm

Update on my cells from my fellow

Good afternoon Deb and Dr. Rhee,

 

Just wanted to inform you that we got good strong reactivity to certain mutation specific antigens against your tumor on our preliminary assay (this is what we want). We are retesting is as our standard protocol and will confirm with you if the retest remains this way. The retesting takes a couple of weeks. If the retesting is positive again we will discuss treatment schedule on our protocol. So essentially the news is good but we will have to wait and see that this is confirmed. Treatment timing will be contingent on response to the recent chemo regimen and availability of the cellular lab. Ballpark will likely March-April but please don’t quote me on this.

Very excited about this. Chemo is getting me down. I have a ct scan Friday so hopefully I will know if the vectabix and irinotecan are working. The rash has been terrible, I'm told that's a good sign. The problem is I feel so much worse than when they found the new Mets.
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs

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Maia
Posts: 2214
Joined: Fri Aug 24, 2012 8:00 am

Re: TIL Immunotherapy at NCI

Postby Maia » Mon Jan 23, 2017 4:04 pm

Hooorrrrrayyyyy!! :D Let's hope!!

teri3
Posts: 322
Joined: Fri Jan 09, 2015 11:03 am

Re: TIL Immunotherapy at NCI

Postby teri3 » Mon Jan 23, 2017 4:12 pm

Wow that's great! Hoping all continues to go well :)

Teri
58 yrs old female
MSS KRAS mutation G12V
adenocarcinoma sigmoid colon dx 11-14
sigmoidectomy 11-14
Stage 3A
3 out of 20 lymph nodes involved
started FolFox 1-27-15
11 rounds FOLFOX last one 6-30-2015
7-29-2015 PET clear
5-14-2016 CT 2 nodules one in each lung
Confirmed pulmonary metastasis stage 4
FOLFIRi + Avistin started 8-16 11 rounds complete 12-16
CT 12-16 nodules shrunk chemo break wait and see :?

jdepp
Posts: 471
Joined: Sun Sep 28, 2008 7:53 pm

Re: TIL Immunotherapy at NCI

Postby jdepp » Mon Jan 23, 2017 4:18 pm

Great news. Good luck & best wishes!
Colon dx 08 @ 41 Poorly diff. 12+ liver mets, 19/28 LN
Colon rsx /14 x Folfox-Erbitux 08-09
PVE / Liver rsx 09
Lung & LN mets 10
Folfiri, Xeloda, Avastin 10-13
Xelox, Erbitux, UFUR, TS-1, Oxi, Lonsurf 14-16
Stivarga & TIL trial 16

Lee
Posts: 4540
Joined: Sun Apr 16, 2006 4:09 pm

Re: TIL Immunotherapy at NCI

Postby Lee » Mon Jan 23, 2017 4:29 pm

That is so totally AWESOME !!

Congratulations,

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

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Sleen
Posts: 278
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Mon Jan 23, 2017 6:44 pm

Way to go, Deb!
Congratulations, this is another hurdle that is now out of your way on the path to treatment!!!

So happy for youuuuu :)

Celine
my blog: Cancer Riot

April 2016: lower left lung lobe removed. NED
8 mo. f/u: Progressive Disease in 1 of 7 tumors.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
partial colectomy Sep 2013 :: KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 26 yrs. kids: 21, 18, 14, 9, 7
SE Michigan home schooler, mechanical engineer, and programmer.

DAS43
Posts: 24
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Fri Jan 27, 2017 1:55 pm

Had a ct scan today. It showed no changes in lung tumors. No new tumors. I have had 6 rounds of irritican and vectabix. Decided to stop chemo until I go to NIH. My magnesium and potassium is low and will be getting iv for that. Hopefully I will regain some energy before I go to NIH. Hope I'm making the right choice.
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs

User avatar
Sleen
Posts: 278
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Fri Jan 27, 2017 2:26 pm

Let the "wash out" begin. Congratulations!

Celine
my blog: Cancer Riot

April 2016: lower left lung lobe removed. NED
8 mo. f/u: Progressive Disease in 1 of 7 tumors.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
partial colectomy Sep 2013 :: KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 26 yrs. kids: 21, 18, 14, 9, 7
SE Michigan home schooler, mechanical engineer, and programmer.

jdepp
Posts: 471
Joined: Sun Sep 28, 2008 7:53 pm

Re: TIL Immunotherapy at NCI

Postby jdepp » Fri Jan 27, 2017 3:50 pm

Deb, I think you'll feel better the further you get from chemo. Great news on your scan.

As for me, I'm scheduled to start the TIL chemo on 2/23 & cell infusion on 3/2.
Colon dx 08 @ 41 Poorly diff. 12+ liver mets, 19/28 LN
Colon rsx /14 x Folfox-Erbitux 08-09
PVE / Liver rsx 09
Lung & LN mets 10
Folfiri, Xeloda, Avastin 10-13
Xelox, Erbitux, UFUR, TS-1, Oxi, Lonsurf 14-16
Stivarga & TIL trial 16

User avatar
Maia
Posts: 2214
Joined: Fri Aug 24, 2012 8:00 am

Re: TIL Immunotherapy at NCI

Postby Maia » Fri Jan 27, 2017 4:16 pm

Yessss!!
Deb and Jed... so hopeful for you both!!! :)

DAS43
Posts: 24
Joined: Thu Aug 18, 2016 8:10 pm

Re: TIL Immunotherapy at NCI

Postby DAS43 » Sat Jan 28, 2017 4:46 am

jdepp wrote:Deb, I think you'll feel better the further you get from chemo. Great news on your scan.

As for me, I'm scheduled to start the TIL chemo on 2/23 & cell infusion on 3/2.


I will be saying prayers for you.
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs

Lee
Posts: 4540
Joined: Sun Apr 16, 2006 4:09 pm

Re: TIL Immunotherapy at NCI

Postby Lee » Sat Jan 28, 2017 3:07 pm

Deb, hope your feeling better soon. All the best at NIH

Jed, good luck to you too.

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

User avatar
Sleen
Posts: 278
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Thu Feb 02, 2017 9:04 pm

Joan Lunden's interview w/Dr. Rosenberg and me for the Today Show broadcast will air on Monday, Feb. 6 on NBC during the 8AM (Eastern) hour.

In anticipation of this, NCI/NIH launched a new website this week which provides preliminary information about Adoptive Cell Therapy (the TIL trial). You can find that here. I've added the link to my signature also.

Celine
my blog: Cancer Riot

April 2016: lower left lung lobe removed. NED
8 mo. f/u: Progressive Disease in 1 of 7 tumors.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2015 stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
partial colectomy Sep 2013 :: KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 26 yrs. kids: 21, 18, 14, 9, 7
SE Michigan home schooler, mechanical engineer, and programmer.

Tim UK
Posts: 50
Joined: Fri Jun 12, 2015 1:05 am

Re: TIL Immunotherapy at NCI

Postby Tim UK » Mon Feb 06, 2017 1:52 pm

Celine -

Thank you for your courage and persistence in helping drive this research forwards. My best wishes,

Tim
https://www.youtube.com/watch?v=qoQbY4A5RNA
05/15 L hemi-colectomy - robotic, laparoscopic
05/15 Dx st 3 T4N2M0 @43
kids: 11,7
BRAFm mucinous - KRASw
06/15 2 liver mets
06/15 CEA 9, CA19-9 400+
06/15 - 09/15 6 x FOLFOXIRI+Avastin
09/15 markers 4/50
10/15 drain-site met
11/15 CRS+HIPEC
1-8/16 BRAF therapy (dabrafenib, panitumumab, trametinib)
CEA;CA19-9: 1/16 16;650 | 2/16 3;690 | 3/16 1;36 | 4/16 2;46 | 5/16 1;29 | 6/16 1;42 | 7/16 2;44 | 8/16 3;72 and 4;135
8/16 progression (PET)
10/16 Trial: NCT02650713


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