TIL Immunotherapy at NCI

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Lee
Posts: 6005
Joined: Sun Apr 16, 2006 4:09 pm

Re: TIL Immunotherapy at NCI

Postby Lee » Wed Feb 12, 2020 1:22 pm

sdino,

AWESOME news!!

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

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Sleen
Posts: 315
Joined: Tue Jan 14, 2014 7:41 am
Location: Detroit
Contact:

Re: TIL Immunotherapy at NCI

Postby Sleen » Thu Feb 13, 2020 9:08 am

I was MSS too, Claudine!
Don't brush it off.
When "they" say immunotherapy doesn't work for MSS, they are talking about infused agents like Keytruda, and Yervoy, etc.

Celine
my blog: Cancer Riot

NED since April 2016!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2014 confirmed stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]

Married 28 yrs. kids: 24, 21, 17, 12, 10
SE Michigan home schooler, unemployed mechanical engineer, and programmer.

Gravelyguy
Posts: 285
Joined: Thu Jul 05, 2018 6:03 pm

Re: TIL Immunotherapy at NCI

Postby Gravelyguy » Thu Feb 13, 2020 9:49 am

sdino wrote:Update 1/24/20: 18 week follow-up at Bethesda Trial NCT01174121, Some good news ! It appears the Tumor Inflitrating Lymphocyctes (TILs) are still Marching. My Wife showed SIGNIFICANT Shrinkage in her lung lesions. However several large "older" ones remained unchanged (which they said is sometimes expected from Older Grandma tumors). No new metasis and no new growth. The Brain tumor has shrunk 95% = almost GONE ! and one liver lesion is Gone and the other liver lesion previously 1.0 cm shows a 90% reduction. So…. the TILs are being systemic meaning they are not confined to only one organ.



That is great news. Thanks for the update!

Dave
6/17 dx mRC t3n1m1 very low rectal tumor 2 liver Mets 1.3 cm and .9 cm

6/17 begin 4 rounds Folfox w/Vectibix
9/17 short course radiation
10/17 rectal and liver resection LAR with coloanal anastomosis (no rectum left)
11/17-3/18 8 rounds Folfox
6/18 still NED!! Takedown
8/28/18 still NED! CEA .8 new low for me
10/18/18 colonoscopy clear
12/12/18 clear scans, CEA .9 still NED!
6/11/19 clear scans CEA 1.0
12/19/19 clear scans CEA 1.0 still NED!

Claudine
Posts: 268
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: TIL Immunotherapy at NCI

Postby Claudine » Thu Feb 13, 2020 10:01 am

Sleen wrote:I was MSS too, Claudine!
Don't brush it off.
When "they" say immunotherapy doesn't work for MSS, they are talking about infused agents like Keytruda, and Yervoy, etc.

Celine


SO GOOD to know that there are still many options out there! Thank you and I hope you stay NED forever :D
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A
No primary (involuted?)
Lytic tumor L4 vertebrae, EBRT radiation 04/18, SBRT 02/19
Resection small intestine 05/18 (no cancer found - Crohn's)
Failed adjuvant Xelox
Folfiri + Avastin since 03/19
6.7 cm left adrenal mass 03/19, 3.67 cm 12/19, successful resection 02/20
CEA since 03/19: high 58, low 3.2, now 10.2
Scan 03/19: Multiple small lung nodules up to 5mm
Scan 12/19: 2 calcified granulomas, one 1mm stable nodule


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