KRAS mutant and KRAS wild

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Girl111
Posts: 234
Joined: Fri Dec 06, 2013 4:43 pm

KRAS mutant and KRAS wild

Postby Girl111 » Sat Jan 03, 2015 3:05 pm

Hi

Can anyone advise as to whether one tumor type is better than the other ?

Also, which treatments are usually given for KRAS mutant ?
Dad diagnosed stage 3 cc nov 13
Bowel resection march 14
Started xeloda
1 liver met and 1 node ( small)
Started irinotecan - failed
Poss nano knife now and oxyplatin
Hope the chem works !

KWT
Posts: 3214
Joined: Thu Jul 11, 2013 7:22 pm

Re: KRAS mutant and KRAS wild

Postby KWT » Sat Jan 03, 2015 3:13 pm

No erbitux for the mutant so I guess that means less options therefore a worse prognosis?

I'm sure I oversimplified this somewhat but I think that's the short version.

eleven11
Posts: 130
Joined: Tue Sep 16, 2014 12:48 pm
Location: Chicago

Re: KRAS mutant and KRAS wild

Postby eleven11 » Sun Jan 04, 2015 3:39 pm

KRAS mutation DOES NOT necessarily indicate a worse prognosis.

There are many stage four patients out there that were able to cut their cancer out, reached NED and have not had any type of genetic testing to determine if they were KRAS mutant or not. Yes, it is one less tool in the tool box, but it does not change standard of care.
11/11 Mom dx @ age 50 T3M0N0
2012 12 tx FOLFOX
12/13 2 lung nodules
1/14 VATS wedge
3/14-present 5FU
4/15 Lobectomy RML

Laurettas
Posts: 1606
Joined: Tue Jun 21, 2011 9:49 pm

Re: KRAS mutant and KRAS wild

Postby Laurettas » Mon Jan 05, 2015 3:14 pm

Girl111, if I read your signature correctly and your dad is Duke's C1, I believe that corresponds to a stage 3 diagnosis. If that is true, there will be no treatment difference for your dad if he is KRAS wild or mutant. The mutation only matters for those who are stage 4 and drugs like Erbitux or Vectibix are sometimes used. Hope that helps.
DH 58 4/11 st 4 SRC CC
Lymph, peri, lung
4/11 colon res
5-10/11 FLFX, Av, FLFRI, Erb
11/11 5FU Erb
1/12 PET 2.4 Max act.
1/12 Erb
5/12 CT ext. new mets
5/12 Xlri
7/12 bad CT
8/12 5FU solo
8/12 brain met
9/12 stop tx
11/4/12 finished race,at peace

KWT
Posts: 3214
Joined: Thu Jul 11, 2013 7:22 pm

Re: KRAS mutant and KRAS wild

Postby KWT » Mon Jan 05, 2015 3:22 pm

Thanks Laurettas, I believe that's what I was meaning. :twisted:

Girl111
Posts: 234
Joined: Fri Dec 06, 2013 4:43 pm

Re: KRAS mutant and KRAS wild

Postby Girl111 » Mon Jan 05, 2015 4:39 pm

Thx all .
I need to change the signature . He was stage 3 but a recent scan showed a liver met so I think that makes it stage 4 .
Dad diagnosed stage 3 cc nov 13
Bowel resection march 14
Started xeloda
1 liver met and 1 node ( small)
Started irinotecan - failed
Poss nano knife now and oxyplatin
Hope the chem works !

User avatar
dianetavegia
Posts: 2724
Joined: Sat May 16, 2009 8:47 pm
Facebook Username: Diane Weldy Tavegia
Location: Villa Rica, Georgia

Re: KRAS mutant and KRAS wild

Postby dianetavegia » Mon Jan 05, 2015 5:20 pm

A more recent study showed that KRAS Mutants have faster cell creation AND faster cell turn-over, apoptosis, which is CELL DEATH and that appears to be good news. Cells might mutate quicker into bad cells but they commit suicide very quickly before becoming mets.

I didn't save the link but had posted it somewhere here a few months ago when KRAS was being discussed. More tests are needed but sounds like good news to me.


American Journal of Clinical Pathology
KRAS Gene Mutation in Colorectal Cancer is Correlated with Increased Proliferation and Spontaneous Apoptosis
Stage III cc surgery 1/7/09. 12 tx FOLFOX
Stage IV PET = 1.5cm liver met. HR 4/11/12

11 years since dx and 7 3/4 years post liver resection.
Pronounced CURED and discharged by onc

“O Lord my God, I cried out to You, And You healed me.” Psalms 30:2

KWT
Posts: 3214
Joined: Thu Jul 11, 2013 7:22 pm

Re: KRAS mutant and KRAS wild

Postby KWT » Mon Jan 05, 2015 5:26 pm

I read that somewhere as well Diane, it's sounds interesting.

Girl111
Posts: 234
Joined: Fri Dec 06, 2013 4:43 pm

Re: KRAS mutant and KRAS wild

Postby Girl111 » Mon Jan 05, 2015 10:06 pm

Thx for that Diane. And thank you all for your comments too .
Dad diagnosed stage 3 cc nov 13
Bowel resection march 14
Started xeloda
1 liver met and 1 node ( small)
Started irinotecan - failed
Poss nano knife now and oxyplatin
Hope the chem works !

User avatar
pollo65
Posts: 1564
Joined: Thu May 20, 2010 3:11 pm
Facebook Username: pollo2
Location: central valley, calif

Re: KRAS mutant and KRAS wild

Postby pollo65 » Tue Jan 06, 2015 5:43 pm

Iam stage 4, kras mutant and celebrated my sixth cancerversary yesterday. Initially I was told that it would hasten my demise but here I am six years later. I have quit trying to figure things out and just go with the flow.
Pollo 65
CC 1/6/09
r. hemi-colectomy 1/7/09
32Ln biopsied, 28 positive
met to aorta
chemo 12 rounds
done 9/09 3 scans clear
1/11 1 met to aorta
micro cluster to peritoneum
4/11 / 9/11 scan clear
4/12 scan clear
10/12 scan clear
Iri+avastin
chemo break

User avatar
dianetavegia
Posts: 2724
Joined: Sat May 16, 2009 8:47 pm
Facebook Username: Diane Weldy Tavegia
Location: Villa Rica, Georgia

Re: KRAS mutant and KRAS wild

Postby dianetavegia » Wed Jan 07, 2015 3:54 pm

Pollo, we're surgery buddies! My resection was 6 years ago today, too!
Stage III cc surgery 1/7/09. 12 tx FOLFOX
Stage IV PET = 1.5cm liver met. HR 4/11/12

11 years since dx and 7 3/4 years post liver resection.
Pronounced CURED and discharged by onc

“O Lord my God, I cried out to You, And You healed me.” Psalms 30:2


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