New gene mutation found in 20% of colon & endometrial cancer

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lpas
Posts: 1010
Joined: Wed Nov 19, 2014 11:11 pm

New gene mutation found in 20% of colon & endometrial cancer

Postby lpas » Sat Dec 20, 2014 10:21 pm

Those with the altered gene (RNF43) may benefit from drugs that target the wrt pathway, which are currently in clinical trial.

http://www.dana-farber.org/Newsroom/News-Releases/Unsuspected-gene-found-frequently-mutated-in-colorectal-endometrial-cancers.aspx
11/14 Dx sigmoid CC @ 45yo
12/14 Colectomy + hysterectomy
Stage IIIB, T3N1bM0, 2/20 nodes, MSS, G2, KRAS(A146T), TP53, SMAD4, ERBB2, CEA 1.0
2/15-7/15 XELOX & celecoxib
2/19 clean scope
11/19 clean CT
Ongoing cimetidine & other targeted supplements
Mom to a 6 & 8yo

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