New gene mutation found in 20% of colon & endometrial cancer

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lpas
Posts: 1007
Joined: Wed Nov 19, 2014 11:11 pm

New gene mutation found in 20% of colon & endometrial cancer

Postby lpas » Sat Dec 20, 2014 10:21 pm

Those with the altered gene (RNF43) may benefit from drugs that target the wrt pathway, which are currently in clinical trial.

http://www.dana-farber.org/Newsroom/News-Releases/Unsuspected-gene-found-frequently-mutated-in-colorectal-endometrial-cancers.aspx
11/14 Dx sigmoid CC @ 45yo
12/14 Colectomy + hysterectomy
Stage IIIB, T3N1bM0, 2/20 nodes, MSS, G2, KRAS(A146T), TP53, SMAD4, ERBB2, CEA 1.0
2/15-7/15 XELOX & Celebrex
3/16 Ovarian mass removed. Benign fibroid
9/16 clean scope
4/18 clean CT
Ongoing Celebrex, Tagamet & other carefully-targeted supplements
Post-chemo CEA 3.0, 2.5, 2.3, 2.0, 1.6, 1.3, 1.8, 2.1, 1.8, 2.0, 1.8, 1.9, 1.7, 1.5, 1.6, 1.5, 1.4, 1.4, 1.3, 1.3, 1.6, 1.6, 1.3, 1.4, 1.6, 2.2, 2.4, 2.1
Mom to a 4 & 6yo

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