New CRC Immunotherapy Trial Announced: anti-PD1 + anti-CSF1R

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DK37
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New CRC Immunotherapy Trial Announced: anti-PD1 + anti-CSF1R

Postby DK37 » Tue Nov 25, 2014 2:22 am

A new CRC immunotherapy combination trial was announced today: anti-PD1 + anti-CSF1R combo.
(not recruiting/in clinicaltrials.gov yet – will be tested against 6 tumor types including CRC starting in 2015)

A combination of BMS’s PD-1 inhibitor with 5-Prime Therapeutic’s anti-CSF1R experimental immunotherapy “FPA008”

Their stated rationale:
“FPA008, an antibody that inhibits colony stimulating factor-1 receptor (CSF1R), blocks the activation and survival of monocytes and macrophages. ... Inhibition of CSF1R in many cancers reduces the number of immunosuppressive tumor-associated macrophages (TAMs), thereby facilitating an immune response against tumors.”
“Preclinical data suggest that combining antibodies targeting PD-1 and CSF1R may lead to an enhanced anti-tumor immune response compared to either approach alone in treating cancer.”

http://news.bms.com/press-release/oncol ... -clinical-
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
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