SBRT with curative intent

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: SBRT with curative intent

Postby Maia » Sun Sep 21, 2014 12:10 pm

Hey Jeff! You know I was 'here' all the time :)
Read about your insurance issues. Bastards.
Just in case you also forget this, what about the Colorado trial "whatever it takes"... do you remember? viewtopic.php?f=1&t=45812#p333314 Definitive Therapy for Oligometastatic Solid Malignancies. Since you have less tumour burden now, and also because usually trials take even people without insurance -and insurance companies are quite obliged to cover trails or you can give them hell... Just brainstorming here.
(Damn... so painful to read Lisa in that thread. But at least she finally went for Dr Morris and had some more months because he operated her :cry: )

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singingholly
Posts: 1133
Joined: Thu Feb 27, 2014 3:37 am
Location: Northern Italy

Re: SBRT with curative intent

Postby singingholly » Sun Sep 21, 2014 1:29 pm

I don't understand Angela: WHO said that SBRT doesen't cure...?!
Olivia
Dec2011 sigm IIIst res T3N1(2/18)M0 Xelox
Oct2012 5liv.mets Dec 2012 liv.res
Jan2013 1liv.met Folfiri+avastin
Jul2013 liv.res Folfiri+/av
Feb2014 10+2lu.mets & 1abd node Folfoxiri+SBRT
Sep2014 Res rx l. BUT spot on diaph:SBRT
Dec2014 3+6lu.mets.Immuno

AngelaN
Posts: 206
Joined: Tue Jan 28, 2014 9:00 pm
Facebook Username: angelamnicholas

Re: SBRT with curative intent

Postby AngelaN » Sun Sep 21, 2014 2:39 pm

Hi Holly -

"Mojo_qize - Our onc says we are still on a curative intent path, but the SBRT doc made it clear the procedure is for local tumor control (there is no systemic component).
She told us they are seeing local control up to 90% at two years (the tumor treated is under control; does not mean disease is not progressing elsewhere)."

"under control" doesn't mean treated, eliminated, destroyed to me...maybe I am splitting hairs. I understand that SBRT is to only treat the tumor but if there is a question I would prefer for DH to have his RUL removed and be done with it. Althougth that would limit our options for later on. But DH doesn't think there will be anymore and my talk about 50% recurrence is offensive and negative....
DH diagnosed with Stage 4 CRC Nov 2013
11 tx Folfox/Avastin; LAR/liver resection/introp RF of liver - May 2014
3 treatments FOLFIRI
Lung resection - Sept 2014
FOLFIRI + Avastin x 10 treatments
Avastin+5FU q3 weeks x 4
SBRT x 1 lung met
RFA for remaining 3 in Oct and Nov
SBRT for liver met Jan 16
lung mets growing
Enrolled in NIH TIL trial Oct 16
XRT for lung met 12/16
Cells didnt grow for TIL trial Feb 17
Waiting for NCT03085914 at Penn

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singingholly
Posts: 1133
Joined: Thu Feb 27, 2014 3:37 am
Location: Northern Italy

Re: SBRT with curative intent

Postby singingholly » Sun Sep 21, 2014 5:14 pm

Ah, ok... Yes of course sbrt is not systemic as a therapy and just like surgery is local. Surgery is safer but sbrt can be definitive as well, there are cases of lesions gone forever after sbrt, aren't they?
Olivia
Dec2011 sigm IIIst res T3N1(2/18)M0 Xelox
Oct2012 5liv.mets Dec 2012 liv.res
Jan2013 1liv.met Folfiri+avastin
Jul2013 liv.res Folfiri+/av
Feb2014 10+2lu.mets & 1abd node Folfoxiri+SBRT
Sep2014 Res rx l. BUT spot on diaph:SBRT
Dec2014 3+6lu.mets.Immuno

mojo_qize
Posts: 3
Joined: Mon Dec 30, 2013 5:35 pm

Re: SBRT with curative intent

Postby mojo_qize » Mon Sep 22, 2014 9:49 am

Holly,
Sorry if my post caused concern. To be clear, our docs indicated that SBRT can definitely be used to eradicate specific tumors, with success rates (that specific tumor being eradicated and not progressing) near those of RFA and other techniques.
Our docs (UCH in Denver, Colorado) just like to be very specific in their communication, thus statements like "this procedure (SBRT for her lung nodules) is not curative, but meant for local tumor control", meaning that doctor is intending to eradicate those specific tumors, but is not making claims that it will cure her (her oncologist who is overseeing the grand plan still considers her to be on a curative intent path because he is orchestrating the entire care plan).
DW dx 4/13 stg IV, 38yo
cln rsct 5/13
Flfx 6/13 - 7/13
Lvr rsct 8/13
Flfx 10/13 - 12/13
scan 11/13 lung spots
CEA rise 2/14
Scan 2/14 2 lvr mets (lng spts stable)
3/14 SBRT lvr
4/14 - 6/14 FLFRI
8/14 scan lng spts declared mets
9/14 SBRT lngs

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singingholly
Posts: 1133
Joined: Thu Feb 27, 2014 3:37 am
Location: Northern Italy

Re: SBRT with curative intent

Postby singingholly » Mon Sep 22, 2014 12:53 pm

It's perfrctly clear, mojo, nevermind! My question was infact about the success rate of SBRT on a single lesion, to make a comparison with surgery. I've always known that it has not systemic effects! Thank you for your answers!
Olivia
Dec2011 sigm IIIst res T3N1(2/18)M0 Xelox
Oct2012 5liv.mets Dec 2012 liv.res
Jan2013 1liv.met Folfiri+avastin
Jul2013 liv.res Folfiri+/av
Feb2014 10+2lu.mets & 1abd node Folfoxiri+SBRT
Sep2014 Res rx l. BUT spot on diaph:SBRT
Dec2014 3+6lu.mets.Immuno

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Rob in PA
Posts: 2022
Joined: Wed Dec 09, 2009 9:16 pm
Location: Pennsylvania

Re: SBRT with curative intent

Postby Rob in PA » Mon Sep 22, 2014 8:10 pm

...I'll also add that a word that's been thrown around by the radiation doc doing the SBRT on me is "oligometastatic". He believes that I've gone long enough with no tumors in my primary area(rectal) and liver (four years since resection) that it is just "hanging around in my lung". The SBRT was used on me with the hope that it would eradicate those that we could see and not small cancer cells that we could not see.

In fact, the two different times I had SBRT done the docs made it a point to remind me that the same "preciseness" of the SBRT procedure that makes it a great treatment option for visible tumors, can turn around and "bite me in the ass" because of that preciseness in terms of missing microscopic tumors that could be as close as a half inch away from the tumor being treated. Hope that makes sense :shock:

In short, I've had six tumors zapped by SBRT over the last three years and NONE of them have come back...they are fried. BUTT, i have had recurrence within a year of both of my SBRT treatments in close but not exactly the same areas of the lung. My hope is that the VATS lobe resection I had last month will take call of the problem area for good. This is the first time I qualified for VATS.
dx 11/07 crc IIIb @ 39
Xelox/Rad/ temp colostomy
LAR/J-pouch/ temp ileo
Folfox-8
Failed reversal
2/09 liver mets; liver resect/ileo reversal
Folfiri/Avastin - 12
2/11 5 lung mets
Folfiri/Avastin 2011
SBRT 3/12
Lung met 5/13/ said NO to more chemo
SBRT 8/13
2 lung mets 5/14, VATS 8/14, NED

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singingholly
Posts: 1133
Joined: Thu Feb 27, 2014 3:37 am
Location: Northern Italy

Re: SBRT with curative intent

Postby singingholly » Tue Sep 23, 2014 2:01 am

Thank you Rob, I'm sure VATS will do the job!
Dec2011 sigm IIIst res T3N1(2/18)M0 Xelox
Oct2012 5liv.mets Dec 2012 liv.res
Jan2013 1liv.met Folfiri+avastin
Jul2013 liv.res Folfiri+/av
Feb2014 10+2lu.mets & 1abd node Folfoxiri+SBRT
Sep2014 Res rx l. BUT spot on diaph:SBRT
Dec2014 3+6lu.mets.Immuno


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