Anyone (besides me) have an autoimmune disease?

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ColOrPan
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Re: Anyone (besides me) have an autoimmune disease?

Postby ColOrPan » Sun Aug 24, 2014 10:32 pm

Graves disease here, it runs in the family on both mother and father's side! Mine has now turned into Hashimoto. I also have psoriasis. It was very mild until my husband was diagnosed then it tuned a little more severe but still moderate. Docs and I believe that it just goes to show the role of stress. It too runs in the family on mother's side. So far none of us have had cancer. That we know of!!!!
06/2012 DH rare intestinal type Ampullary/duodenal cancer. They extrapolate from colon cancer. FOLFOX 6 been working since Aug 2013. Feb 2014 once a month folfox as maintenance.
May 2014 Folfiri - fail
Starting off-label JAKAFI 08/25/14

Stanfordmom
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Re: Anyone (besides me) have an autoimmune disease?

Postby Stanfordmom » Sun Aug 24, 2014 10:52 pm

Bev,

I don't have any autoimmune disease but I have had hay fever which is also a reflection of hyperactive immune system.

I was also curious how your surgeon figured out the ages of your primary tumor and met. That is interesting he can tell the age of the tumors :)

Sha
DX 4/2/2014 at 44, stage 4, mets liver and ovaries
Mom to 2 boys
Three surgeries, HAI pump and lots of chemo
fighting!

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singingholly
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Location: Northern Italy

Re: Anyone (besides me) have an autoimmune disease?

Postby singingholly » Sun Aug 24, 2014 11:13 pm

How many... The opposite theory could be that an error in our immune system causes both the attack to our own body AND cancer. Wrong target...
Dec2011 sigm IIIst res T3N1(2/18)M0 Xelox
Oct2012 5liv.mets Dec 2012 liv.res
Jan2013 1liv.met Folfiri+avastin
Jul2013 liv.res Folfiri+/av
Feb2014 10+2lu.mets & 1abd node Folfoxiri+SBRT
Sep2014 Res rx l. BUT spot on diaph:SBRT
Dec2014 3+6lu.mets.Immuno

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pollo65
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Location: central valley, calif

Re: Anyone (besides me) have an autoimmune disease?

Postby pollo65 » Sun Aug 24, 2014 11:34 pm

Hashimotos and IBS prior to my DX and strangely I asked my onc and he seemed interested in the link between auto immune problems and long term survival.
Pollo 65
CC 1/6/09
r. hemi-colectomy 1/7/09
32Ln biopsied, 28 positive
met to aorta
chemo 12 rounds
done 9/09 3 scans clear
1/11 1 met to aorta
micro cluster to peritoneum
4/11 / 9/11 scan clear
4/12 scan clear
10/12 scan clear
Iri+avastin
chemo break

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sun-sparkled waves
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Location: Canada

Re: Anyone (besides me) have an autoimmune disease?

Postby sun-sparkled waves » Mon Aug 25, 2014 12:41 am

Hashimoto's Thyroiditis here, too. Autoimmune skin condition, maybe psoriasis. Chronic Fatigue Syndrome which I don't know if it's autoimmune, but it certainly effects my immune system.
Stage 2b in ascending colon age 34
Right Hemicolectomy 1994
5 FU and Levamisole for 6 months
Lynch Syndrome mutation MLH1
Bilateral Salpingectomy 2010

weisssoccermom
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Re: Anyone (besides me) have an autoimmune disease?

Postby weisssoccermom » Mon Aug 25, 2014 1:24 am

Hashimoto's for me and for a large portion of my family....mom, aunt (on maternal side), grandmother...seems to be fairly common on the female side of the family. I guess I hadn't really realized it was considered an autoimmune disease.
Dx 6/22/2006 IIA rectal cancer
6 wks rad/Xeloda -finished 9/06
1st attempt transanal excision 11/06
11/17/06 XELOX 1 cycle
5 months Xeloda only Dec '06 - April '07
10+ blood clots, 1 DVT 1/07
transanal excision 4/20/07 path-NO CANCER CELLS!
NED now and forever!
Perform random acts of kindness

Ron50
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Re: Anyone (besides me) have an autoimmune disease?

Postby Ron50 » Mon Aug 25, 2014 2:01 am

I have psoriasis, only mild thankfully. I have grade two ankolysing spondylitis. I have severe psoriatic arthritis. My nephrologist and neurologist are inclined to think my motor sensory neuropathy is auto-immune. I have nephrotic syndrome ,losing 7 grams a day of protein thru my urine. I have had three kidney biopsies and the problems do not relate to known kidney diseases. My nephrologist has diagnosed it as an auto immune disease of unknown type and cause. I have mild auto immune hepatitis. I have been on methotrexate for years but last year it stopped working. I had parainfluenza last November and it caused a lot of flares particularly my nephrotic syndrome loss nearly went to 8 grams and it caused some troponin leakage from my heart. I am now on 75mg morning and night of cyclosporine. It has helped the protein loss and may help The PSA and AS. I have been on it 8 months and so far apart from hair growth and gum growth no serious side effects.Ron.
dx 1/98
st 3 c 6 nodes
48 sessions 5Fu/levamisole
no recurrence cea <.5
numerous l/t side effects of chemo

jacekica
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Re: Anyone (besides me) have an autoimmune disease?

Postby jacekica » Mon Aug 25, 2014 6:50 am

Psoriasis here, fortunately mostly on non visible places - legs' the most on left feet, just erupted few weeks ago accompanion of worsening with pain and fatigue.
Dx 2/11
surgery 5/11, T2N0MX, G2, SRC rectal ca, 22 cm removed
CT- numerous mets in abdomen - LN, 2 big ones on pancreas, one penetrated right urether. Surgery, they just take samples for PHD, 6 roundds 5FU, refuse further chemos

tammylayne
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Re: Anyone (besides me) have an autoimmune disease?

Postby tammylayne » Mon Aug 25, 2014 7:08 am

Raynaud's here, I know when I had radiation it was a concern as you can develop issues down the road when you combine the two...butt three years later no one seems interested in following it up.
51 F
'06 Stage 1 CC,
'10 Stage 3 Rectal

"You never know how strong you are until you have to become your own hero."

Dori W
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Facebook Username: Dori Woodhouse

Re: Anyone (besides me) have an autoimmune disease?

Postby Dori W » Mon Aug 25, 2014 2:34 pm

I was told my "chronic idiopathic" hives are probably autoimmune in origin.
Diagnosed stage 3C signet ring colon cancer in May, 2008
14 out of 18 positive lymph nodes
Final treatment in November, 2008
NED ever since
I used to have an account under "Dori," but I've lost access to it.
You can view my old posts here: search.php?author_id=1446&sr=posts

mjkelley
Posts: 131
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Location: Greater Sacramento area

Re: Anyone (besides me) have an autoimmune disease?

Postby mjkelley » Mon Aug 25, 2014 4:33 pm

I had mild/moderate RA.

I had two thoughts go through my head....

1. my body knew something was wrong (the cancer) but couldn't "find" it, so it went on attack.

2. (Which I feel much stronger about) The drugs I took for the RA lowered my immune system, and allowed the cancer to take hold.
DX 1/30/10 @ 49
stage iv with In-numerable mets to Liver
Treatment plan: Chemo for life
40 rounds folfox Feb 2010 to October 2011
Dropped oxi October 2011
REDUCTION OR NO NEW GROWTH
July 2013 Growth
Back on oxi July 2013
More Growth
Folfori October 2013

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juliej
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Re: Anyone (besides me) have an autoimmune disease?

Postby juliej » Mon Aug 25, 2014 5:19 pm

Bev G wrote:I have done a search of the literature and find nothing related to cancer in people with type 1 diabetes, which I think is a little weird as there is so much work being done now with immunotherapy and cancer.

Bev, I found the following two studies.

There was a 2003 cohort study in Sweden that looked at cancer risk in type 1 diabetes patients. It found a 20% increase in overall cancer incidence among type 1 diabetes patients. Patients with type 1 diabetes had elevated risks of cancers of the stomach, cervix, and endometrium.

J Natl Cancer Inst. 2003 Dec 3;95(23):1797-800.

Then there was a similar cohort study in 2010. It found a significant increase for gastric and skin (squamous cell carcinoma) cancers and for leukemia.

Diabet Med. 2010 Jul;27(7):791-7. doi: 10.1111/j.1464-5491.2010.03011.x.

However, I also found a 2013 NCI article about a mouse study involving a gene called BACH2. Previous research had shown that people with minor variations in the BACH2 gene often develop allergic or autoimmune diseases. In this study in mice, the Bach2 gene was found to be a critical regulator of the immune system’s reactivity. At the end of the article it says researchers are "now working toward manipulating the activity of the Bach2 gene, with the goal of developing a new cancer immunotherapy." :D

So it looks like that might be the connection between autoimmune diseases and cancer. Hope this helps!

The immune system is comprised of a variety of cell types that must act in unison to maintain a healthy balance. White blood cells called CD4+T cells play a dual role within the immune system. Some CD4+T cells activate immune responses, whereas others, called regulatory T cells, function in the opposite direction by constraining immune responses. This duality is important because uncontrolled immune responses may result in immune system attacks against the body’s own cells and tissues, which occurs in allergic and autoimmune diseases. One of the hallmarks of uncontrolled immune responses is excessive tissue inflammation. Although tissue inflammation is a normal part of immune responses, excessive inflammation can lead to tissue and organ damage and may be potentially lethal. How CD4+T cells become either activating/inflammatory or regulatory is not well understood, according to the researchers.

“We found that the Bach2 gene played a key role in regulating the switch between inflammatory and regulatory cells in mice,” said NIAMS researcher Kiyoshi Hirahara, M.D. “The loss of the Bach2 gene in CD4+ T cells caused them to become inflammatory, even in situations that would normally result in the formation of protective regulatory cells.”

The team found that if mice lacked the Bach2 gene their cells became inflammatory and the mice died of autoimmune diseases within the first few months of life. When they re-inserted Bach2 (using gene therapy) into Bach2-deficient cells, their ability to produce regulatory cells was restored.

"Although genes have been found that play specific roles in either inflammatory cells or regulatory cells, Bach2 regulates the choice between the two cell types, resulting in its critical role in maintaining the immune system’s healthy balance," said NCI principal investigator, Nicholas P. Restifo, M.D., "It’s apt that the gene shares its name with the famous composer Bach, since it orchestrates many components of the immune response, which, like the diverse instruments of an orchestra, must act in unison to achieve symphonic harmony."

Restifo suggests that these findings have implications for cancer as well, since cancers co-opt regulatory T cells to prevent their own destruction by antitumor immune responses. He and his colleagues are now working toward manipulating the activity of the Bach2 gene, with the goal of developing a new cancer immunotherapy. Also, as this study was in mice, it must be replicated in humans before its findings can be applied in a clinical setting.

http://www.cancer.gov/newscenter/newsfromnci/2013/BACH2
Stage IVb, liver/lung mets 8/4/2010
Xelox+Avastin 8/18/10 to 10/21/2011
LAR, liver resec, HAI pump 11/2011
Adjuvant Irinotecan + FUDR
Double lung surgery + ileo reversal 2/2012
Adjuvant FUDR + Xeloda
VATS rt. lung 12/2012 - benign granuloma!
VATS left lung 11/2013
NED 11/22/13 to 12/18/2019, CEA<1

kiwiinoz
Posts: 1155
Joined: Thu Jan 03, 2013 11:44 pm

Re: Anyone (besides me) have an autoimmune disease?

Postby kiwiinoz » Mon Aug 25, 2014 8:03 pm

mjkelley wrote:I had mild/moderate RA.

I had two thoughts go through my head....

1. my body knew something was wrong (the cancer) but couldn't "find" it, so it went on attack.

2. (Which I feel much stronger about) The drugs I took for the RA lowered my immune system, and allowed the cancer to take hold.


I agree, why prescribe immune suppressing drugs if it increases the risk of cancer?
Stage IV Rectal Cancer (39 Year old male at dx)
pT3N0M1 (wish that was M0)
Diagnosed 05 Dec 2012
LAR 05 Jan 2013
VATS 27 Feb 2013
FOLOFX April 2013 - Sep 2013
Clear Scan 03 Dec 2013 - 22 May 2019
Port Out 26 March 2015

Badass
Posts: 1171
Joined: Sun Jan 15, 2012 11:42 am

Re: Anyone (besides me) have an autoimmune disease?

Postby Badass » Mon Aug 25, 2014 8:28 pm

Hi Bev,
Another Hoshimto diagnosis here! Is it possible some immune response to cellular changes kicked off my autoimmune issues years before the tumor appeared?

Also, Jeremy great to hear from you! I too have been wondering about you.

Jane (Rusuja)
R.C. 12/23/11 at age 52 T3N0M0
3/1/12 completed Xeloda and radiation
5/4/12 LAR & Ileostomy
6/7/12-10/4/12 6 rounds Xelox
11/27/12 Reversal
7/13/13 1 liver met
8/13 Met resection /hai pump
4/14 Chemo completed (Irinotecan/5fu/fudr in pump)

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Cherie
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Location: New Zealand

Re: Anyone (besides me) have an autoimmune disease?

Postby Cherie » Tue Aug 26, 2014 2:13 am

Yes, and it caused my cancer. There is a clear link that some autoimmune diseases can lead to cancer.
36Yo F
2000 UC
2013 Stage 4 CC 15/126 LN spread to the omentum
June Collectomy all visible cancer removed
July Folfox + Avastin
2/14 clean scan
8/14 Ileo-anal pouch surgery still NED
1/15 Emergency illeostomy spread to peritoneum and small bowel


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