Anyone every have the anti-nausea drug Kytril?
Anyone every have the anti-nausea drug Kytril?
I am planning on being involved in a clinical trial starting in mid-august. One of the anti-nausea drugs used as part of the IV infusion is Kytril (granisetron). Just curious what side effects, if any you experienced.
3/11 IIIC +/FOLFOX
4/12 HIPEC
6/12 Chmo/Rad
9/12 XELIRI+Avast/Zltra
9/13 Plvic Absc,stpd chemo
11/13 Tumr rmvd frm Lap Port incis
12/13 Xeloda
1/14 Cardiac Issue no Xeloda/5FU
3/14 Irinotecan
6/14 Stopped chemo
8/14 Clin Trial
9/14 Infectn - Stpd Trial
4/12 HIPEC
6/12 Chmo/Rad
9/12 XELIRI+Avast/Zltra
9/13 Plvic Absc,stpd chemo
11/13 Tumr rmvd frm Lap Port incis
12/13 Xeloda
1/14 Cardiac Issue no Xeloda/5FU
3/14 Irinotecan
6/14 Stopped chemo
8/14 Clin Trial
9/14 Infectn - Stpd Trial
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michelle c
- Posts: 1929
- Joined: Wed Dec 02, 2009 3:58 am
Re: Anyone every have the anti-nausea drug Kytril?
Hi Ray,
Just wanted to wish you all the very best for your clinical trial.
Sorry, but I have no experience with granisetron but just wondering if it from the same family as ondansetron (Zofran).
Just wanted to wish you all the very best for your clinical trial.
Sorry, but I have no experience with granisetron but just wondering if it from the same family as ondansetron (Zofran).
Last edited by michelle c on Wed Jul 23, 2014 10:02 pm, edited 1 time in total.
May 25 2009 Dx with CC (sigmoid colon) 2 days after my 44th b'day
CEA prior to surgery 4.7
Jun 3 2009 LAR - Stage III 3/10 lymph nodes
Jul 6 - Dec 10 2009 - 12 cycles FOLFIRI
Genetic testing - inconclusive for Lynch
Jul 2012 port removed & hernia repair
CEA prior to surgery 4.7
Jun 3 2009 LAR - Stage III 3/10 lymph nodes
Jul 6 - Dec 10 2009 - 12 cycles FOLFIRI
Genetic testing - inconclusive for Lynch
Jul 2012 port removed & hernia repair
Re: Anyone every have the anti-nausea drug Kytril?
Though now I have a duh moment. I should have searched the board first! And actually I guess I did as I did a google search on Kytril versus Zofran and posts came up from this board. I know there was a member poo-pooing the public aspect, but it works for me.
3/11 IIIC +/FOLFOX
4/12 HIPEC
6/12 Chmo/Rad
9/12 XELIRI+Avast/Zltra
9/13 Plvic Absc,stpd chemo
11/13 Tumr rmvd frm Lap Port incis
12/13 Xeloda
1/14 Cardiac Issue no Xeloda/5FU
3/14 Irinotecan
6/14 Stopped chemo
8/14 Clin Trial
9/14 Infectn - Stpd Trial
4/12 HIPEC
6/12 Chmo/Rad
9/12 XELIRI+Avast/Zltra
9/13 Plvic Absc,stpd chemo
11/13 Tumr rmvd frm Lap Port incis
12/13 Xeloda
1/14 Cardiac Issue no Xeloda/5FU
3/14 Irinotecan
6/14 Stopped chemo
8/14 Clin Trial
9/14 Infectn - Stpd Trial
Re: Anyone every have the anti-nausea drug Kytril?
I had kytril, it worked fine for me. No crazy side effects. If I recall, I got it in IV form when i got my chemo...then had Zofran pills for at home.
dx 11/07 crc IIIb @ 39
Xelox/Rad/ temp colostomy
LAR/J-pouch/ temp ileo
Folfox-8
Failed reversal
2/09 liver mets; liver resect/ileo reversal
Folfiri/Avastin - 12
2/11 5 lung mets
Folfiri/Avastin 2011
SBRT 3/12
Lung met 5/13/ said NO to more chemo
SBRT 8/13
2 lung mets 5/14, VATS 8/14, NED
Xelox/Rad/ temp colostomy
LAR/J-pouch/ temp ileo
Folfox-8
Failed reversal
2/09 liver mets; liver resect/ileo reversal
Folfiri/Avastin - 12
2/11 5 lung mets
Folfiri/Avastin 2011
SBRT 3/12
Lung met 5/13/ said NO to more chemo
SBRT 8/13
2 lung mets 5/14, VATS 8/14, NED
Re: Anyone every have the anti-nausea drug Kytril?
Ray,
This drug:
http://en.wikipedia.org/wiki/Granisetron
is similar to Zofran:
http://en.wikipedia.org/wiki/Ondansetron
and acts in the same manner. One thing that has been shown to be a problem with Zofran is QT prolongation. This may be why they are choosing to use Kytril rather than Zofran. Given your previous cardiac issue thought to be from 5-FU/Xeloda it might be a good idea to use a drug without known QT prolongation. Otherwise I expect the side effects from this drug to be very similar to your experience with Zofran if you have used it in the past.
Regards,
GrouseMan
This drug:
http://en.wikipedia.org/wiki/Granisetron
is similar to Zofran:
http://en.wikipedia.org/wiki/Ondansetron
and acts in the same manner. One thing that has been shown to be a problem with Zofran is QT prolongation. This may be why they are choosing to use Kytril rather than Zofran. Given your previous cardiac issue thought to be from 5-FU/Xeloda it might be a good idea to use a drug without known QT prolongation. Otherwise I expect the side effects from this drug to be very similar to your experience with Zofran if you have used it in the past.
Regards,
GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017
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kimanne
- Posts: 44
- Joined: Sat Sep 03, 2011 10:47 pm
- Facebook Username: kim.garner.goodrich
- Location: Rochester, NY
Re: Anyone every have the anti-nausea drug Kytril?
Used it a lot a couple of years ago and always had it in IV form before chemo. It is VERY constipating. Have some Colace or such on hand 
DX 11/10 st 3 at 45 yr
Folfox 1-4/11
Rad 5/11
6/11 Scan - Primary gone 2 LN-St 4
Folfox Avastin 8/11
Rad 10/11
1-12/12 Folfiri Avast
3/12-12/12 Scans,shrinking
1/13 5FU&Avastin
4/13 Avastin only-stable
5/14 STROKE
7/14 Recurrence
8/14 APR
Folfox 1-4/11
Rad 5/11
6/11 Scan - Primary gone 2 LN-St 4
Folfox Avastin 8/11
Rad 10/11
1-12/12 Folfiri Avast
3/12-12/12 Scans,shrinking
1/13 5FU&Avastin
4/13 Avastin only-stable
5/14 STROKE
7/14 Recurrence
8/14 APR
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NWgirl
- Posts: 6659
- Joined: Sat Feb 02, 2008 3:24 am
- Facebook Username: Belle Piazza
- Location: Battle Ground, Washington
Re: Anyone every have the anti-nausea drug Kytril?
Kytril has been a standard drug for me prior to chemo. No side effects I know of. IV only - not something I use at home.
Belle - "Don't Retreat - Reload"DX 10/07 Stage III Rectal
Surgery 11/07; 27 of 38 nodes
Perm Colostomy 8/11
12/10 recurrence lungs & LN's
VATS Jan 2011
Radiation Oct 2013
Chemo for Life
2012 Colondar Model
Surgery 11/07; 27 of 38 nodes
Perm Colostomy 8/11
12/10 recurrence lungs & LN's
VATS Jan 2011
Radiation Oct 2013
Chemo for Life
2012 Colondar Model
Re: Anyone every have the anti-nausea drug Kytril?
I took Kytril during Chemo in pill form. 5 pills at start of chemo and then pills twice a day for the next 2 days. Did not have any problem with them at all.
Stage IV colon with mets to liver October 07
Stage II kidney cancer November 2007
4 surgeries 2 liver, kidney and colon
NED
Stage II kidney cancer November 2007
4 surgeries 2 liver, kidney and colon
NED
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