BRAF - Possible help for BRAF mutant patients

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ColOrPan
Posts: 378
Joined: Thu Aug 22, 2013 2:15 pm

BRAF - Possible help for BRAF mutant patients

Postby ColOrPan » Tue Jan 14, 2014 9:24 pm

Off-label use of cetuximab plus sorafenib and panitumumab plus regorafenib to personalize therapy for a patient with V600E BRAF-mutant metastatic colon cancer

https://www.landesbioscience.com/journa ... cle/25191/

This is the same thing but on the NIH site: -> http://www.ncbi.nlm.nih.gov/pubmed/23792568
06/2012 DH rare intestinal type Ampullary/duodenal cancer. They extrapolate from colon cancer. FOLFOX 6 been working since Aug 2013. Feb 2014 once a month folfox as maintenance.
May 2014 Folfiri - fail
Starting off-label JAKAFI 08/25/14

Mommato4boys
Posts: 75
Joined: Wed May 15, 2013 8:53 pm
Facebook Username: Debbie Rech Whitmore

Re: BRAF - Possible help for BRAF mutant patients

Postby Mommato4boys » Tue Jan 14, 2014 11:56 pm

Thank so much for the information!
47 yo BRAF mutant
Dx: Age 44: Nov. 2011. stage IV. >20 liver mets, +15/21 nodes pos.
Mets in peritoneum, liver, lymph, ovary
Stage 3 thyroid cancer 1999
Caringbridge-debbiewhitmore
Interview:weei Debbie Whitmore

Ratepo
Posts: 71
Joined: Thu Oct 10, 2013 1:56 am

Re: BRAF - Possible help for BRAF mutant patients

Postby Ratepo » Wed Jan 15, 2014 3:37 am

Dunno if it's exactly the same, but here in the Netherlands there is also a study regarding this topic. In one of the most popular tv-shows here were the researchers and a woman receiving the therapy which triggered the attention a couple months ago. Here is some more info about it: http://www.ncbi.nlm.nih.gov/pubmed/22281684 and http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672971/
Father dx 10/12 rectal 4a
11/12 3 liver mets resected
01/13 colostomy
07/13 scan: 1 liver met, op. failed: multiple discovered, start xelox
12/13 mets shrink (kras mut.)
01/14 liver op new hospital: 2 mets removed others disappeared
05/14 & 09/14 NED
01/15 CEA rise to 5
05/15 local reccurence - rad + Xeloda
10/15 op. failed unremovable mets lower pelvis

ColOrPan
Posts: 378
Joined: Thu Aug 22, 2013 2:15 pm

Re: BRAF - Possible help for BRAF mutant patients

Postby ColOrPan » Thu Jan 23, 2014 8:58 am

Bumping for Debbie - Debzak
06/2012 DH rare intestinal type Ampullary/duodenal cancer. They extrapolate from colon cancer. FOLFOX 6 been working since Aug 2013. Feb 2014 once a month folfox as maintenance.
May 2014 Folfiri - fail
Starting off-label JAKAFI 08/25/14


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