FUDR reduced

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FUDR reduced

Postby Badass » Wed Oct 30, 2013 4:04 pm

Due to elevated liver enzymes Dr. K. reduced my dose to less than 50%. Has me very worried.
R.C. 12/23/11 at age 52 T3N0M0
3/1/12 completed Xeloda and radiation
5/4/12 LAR & Ileostomy
6/7/12-10/4/12 6 rounds Xelox
11/27/12 Reversal
7/13/13 1 liver met
8/13 Met resection /hai pump
4/14 Chemo completed (Irinotecan/5fu/fudr in pump)

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Re: FUDR reduced

Postby paula » Wed Oct 30, 2013 4:47 pm

same thing happened to me; it's very common - the good news is that your infusion was not cancelled altogether - like mine was a few times. In fact, I only had 3 out of the 6 infusions. And I've been NED for awhile now, so try not worry too much..
Love 'n Light
3/08 Stage IIIa, colon resection, 12 rounds folfox
5/10 recurrence; right lobe liver metastasis
Hepatic resection 6/10; HAI pump and 6 months folfox/FUDR
Currently NED

The world is unfathomably beautiful today

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Re: FUDR reduced

Postby juliej » Wed Oct 30, 2013 4:49 pm

Liver enzymes can get quite high on FUDR, Jane. That's why they monitor them so carefully. FUDR is so strong that you're still getting a big dose at 50% reduction. Sending good thoughts your way!
Stage IVb, liver/lung mets 8/4/2010
Xelox+Avastin 8/18/10 to 10/21/2011
LAR, liver resec, HAI pump 11/2011
Adjuvant Irinotecan + FUDR
Double lung surgery + ileo reversal 2/2012
Adjuvant FUDR + Xeloda
VATS rt. lung 12/2012 - benign granuloma!
VATS left lung 11/2013
NED 11/22/13 to 12/18/2019, CEA<1

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Re: FUDR reduced

Postby radnyc » Wed Oct 30, 2013 6:27 pm

As previous posters noted, don't worry too much, FUDR was reduced for me as well. It's not uncommon on this protocol for liver enzymes to shoot up. It's probably one of the reasons why MSK is the main center in the country where HAI therapy is performed and is proven effective. It needs to have constant oversight by people thoroughly trained for it. Dr. Kemeny, although not my Oncologist, was consulted when needed by my doc. It's her protocol, with many years of proven efficacy, and they all follow it to the letter. Hang in there, she knows what she's doing.

DX Jan '10, at 47
Feb - colon resection - 2/17 nodes
April - liver mets - Stage 4
3 months Folfox chemotherapy
August '10 liver resection and HAI pump
7 months chemo FUDR HAI and Folfiri systemic
NED since August 2010
Last treatment April '11
HAI Pump removed Dec '15

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Re: FUDR reduced

Postby mom_2_3 » Wed Oct 30, 2013 8:20 pm

My liver enzymes were also elevated as I moved further through treatment and my FUDR was decreased a bit. Try not to worry!!

CC discovered during c-section (11/4/08)
Diagnosed Stage IV 11/10/08 -- Happy 39th Birthday! 5 bilobar liver mets
02/09: Colectomy, liver resection, HAI pump implanted, 7 of 42 nodes
7 months of FUDR and 5FU ended 11/2/09
10 years NED.

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Re: FUDR reduced

Postby debzak » Wed Oct 30, 2013 8:22 pm

I had to skip my second infusion due to my liver enzymes. Now I take some pill twice a day to keep them in check. I think she lowered my dose too.

It was really nice meeting you today. My treatment went well and we were done by 4:00.

Wishing you continued success with your treatment and maybe we can meet again.

2/27/12 dx rectal cancer (stage III)
3/6/12 44th B-day
3/19/12 Oxi & 5-FU (8 rounds)
7/9/12 chemo-rad
11/5/12 LAR surgery temp ileo
1/20/13 4 rounds Xeloda
5/13 multiple liver mets
6/4/13 HAI pump at Sloan
KRAS wild & BRAF mutation found :(

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Re: FUDR reduced

Postby Guinevere » Wed Oct 30, 2013 11:22 pm

Do you know which liver enzymes were elevated. I've had high alkaline phosphatase counts for 28 years. I know there's another liver thing LDH (I had mistakenly got this mixed up with good cholesterol initials) and that's gone higher recently but not enough for my onc to be concerned.

God bless ~
Hrt atk - Feb 11
CRC4 DX - Apr 11
APR liver rsct, procto - Jul 11
Folfox/Avastin - Sep 11
Xeliri - Nov 11
Iritux - Jun 12
Break - Jan - Mar 13
Iritux - Mar 13
Stivarga - Aug 13
Folfiri - Oct 13
Exhausted treatment options - May 14

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Joined: Sun Jan 15, 2012 11:42 am

Re: FUDR reduced

Postby Badass » Wed Oct 30, 2013 11:33 pm

My goodness, CC'ers are the best! You all have provided me with so much information and reassurance. I think I left feeling like I personally was having a problem with the treatment and, thus, would have a lightweight version of the real deal. Now I understand the bigger picture and how often these adjustments are made. And with success. Thank you!
Gwen, I will check which enzymes when they are posted on the portal. Thanks for sharing your experience.
Debbi, I really enjoyed meeting you and your husband and I am glad things went smoothly and quickly once you finally got in. It was fun to meet up and hope to see you again

R.C. 12/23/11 at age 52 T3N0M0
3/1/12 completed Xeloda and radiation
5/4/12 LAR & Ileostomy
6/7/12-10/4/12 6 rounds Xelox
11/27/12 Reversal
7/13/13 1 liver met
8/13 Met resection /hai pump
4/14 Chemo completed (Irinotecan/5fu/fudr in pump)

justin case
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Location: Katy, Texas

Re: FUDR reduced

Postby justin case » Thu Oct 31, 2013 6:13 pm

I hate to say it, but it seems those doctors up in New York, seem to know what they are doing, I wish they knew something about salsa. I hope you are doing well my friend, but I really don't know a thing about your treatment protocol.
Warm regards,
7/11 diagnosed Stage 2 colon and rectal cancer
lar/temp ilio
Reversal & port removal
21 round of chemo Folfox 9tx, 5fu 12 tx
Last treatment July 2012

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Re: FUDR reduced

Postby CRguy » Thu Oct 31, 2013 6:34 pm

justin case wrote:..... I wish they knew something about salsa. l
New York CITY ????? ... Old El Paso tag line if I ever heard one Michael :mrgreen:

.......rusuja sending Cheers and Mega Vibes and am also in the "liver enzymes increase for a lotta reasons" club ! Had dose reductions on both Xeloda and FOLFOX.

The liver is the main engine for processing and detoxing everything we put into our bodies and my enzymes were always elevated after chemo. The docs should always err on the safe side and if a short delay or dose reduction is best for YOU ... so be it. Same thing with blood counts. Sometimes the body just needs a little more time to get things in order before more treatments.

Caregiver x 4
Stage IV A rectal cancer/lung met
14 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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