junel1025 wrote:Thank you so much for your responses. I have not yet discussed with my doctor. the reactions were very similar to 5fu only this time I didn't end up in the hospital. interesting that with the extremely severe reaction to 5fu that she would recommend zeloda. I will check out the test you suggest
horizon wrote:I remember reading about people that had problems when switching from 5FU to Xeloda immediately. I don't know how much truth their is to it but maybe ask you doctor to research it?
http://fightcolorectalcancer.org/resear ... de_effects
In chemotherapy-naı¨ve patients, capecitabine produced more toxicity than FU/LV, but at levels in line with previously reported data. However, treatment with capecitabine after FU/LV caused markedly increased toxicity, indicating a sequence-speciﬁc interaction. The mechanism has not been determined, but interaction with intracellularly retained folate after FU/LV therapy is a possibility. Oncologists need to be aware of this risk if considering crossing patients over from FU/LV to capecitabine-based regimens.
In conclusion, from a clinical viewpoint, we have identiﬁed a signiﬁcant and potentially life-threatening, sequence-speciﬁc toxicity
when switching patientsfrom FU/LV to capecitabine. Themechanism is currently undetermined, but one possible reason is persisting intracellular folate repletion following LV dosing. Our experience and current knowledge preclude us from recommending a speciﬁc safe
washout period or dose reduction for patients switching from FU/LV to capecitabine. However, oncologistswanting to switch patientsfrom
FU/LV to capecitabine need to be aware of this risk and should exercise due caution. This caution should also be extended to switching
patients from combination regimens containing FU/LV to capecitabine-containing equivalents (eg, from infusional FU/LV with oxaliplatin to capecitabine with oxaliplatin).
Although 5-FU is still the most widely prescribed agent for the treatment of colorectal cancer, less than one-third of patients achieve objective responses.
pukalania wrote:Not sure if this would help but we add 200mg Celebrex twice a day with each does of xeloda good luck
DLA wrote:I didn't see a response to the question of what kind of reaction you had to both 5FU and Xeloda. I took Xeloda for 6 months and if you would be kind enough to share what issues you had, I and others could possibly provide some suggestions for dealing with the side-effects. I wish you the best and hope that a chemo treatment plan can be found that you will be able to tolerate. Taking chemo isn't fun and there is a certain amount of 'hang with it' that needs to be employed.
Al the best,
Users browsing this forum: No registered users and 4 guests