Postby shartwell@ipns.com » Thu Feb 21, 2013 2:16 am
>Still she started regorafenib today. What choice does one have when one does not want to give up and everything else has failed? Would you do Regenofenib again?
I wouldn't, but I think Susan would. Though oncologist thought there might be some life extension from, iirc, cetuximab, which Suze had had before, Suze wanted to take her chances with something new. With hindsight, I think regorafenib should be ruled out for colon cancer patients whose livers are already compromised. Suze had already had most of it whacked away to remove a big liver met when they removed the primary lesion from the colon, and in the same extended surgery had a lesion in what remained of her liver ablated. More of it suffered when two 60-grey doses of gamma rays were necessary to kill a met too near her bile duct to be cut or ablated. Even though the liver panel showed, in the oncologist's view, not too much deterioration at the time we started regorafenib, the lesson is that that is one drug which a damaged liver with a giant liver met cannot withstand. Still, I think Susan would have gambled again.