High Monocytes, MCV, & MCHC

Please feel free to read, share your thoughts, your stories and connect with others!
Luck12

High Monocytes, MCV, & MCHC

Postby Luck12 » Thu Sep 27, 2012 7:02 pm

Hello Everyone,

Just got my blood test back today, and for the first time in 4 test my Monocytes, MCV, and MCH are hight. Is this something to be concerned about? I see my oco on Tuesday. I'm stage 3b.

Thanks!!!

Roddy

SoConfused
Posts: 1024
Joined: Mon Jan 30, 2012 2:40 pm

Re: High Monocytes, MCV, & MCHC

Postby SoConfused » Thu Sep 27, 2012 11:34 pm

are you taking xeloda? if so, it may be the culprit.
Stage IV CC

Luck12

Re: High Monocytes, MCV, & MCHC

Postby Luck12 » Fri Sep 28, 2012 10:21 am

Hello,

Yes, I am taking Xeloda.

Thanks!!!

Roddy

User avatar
juliej
Posts: 3001
Joined: Thu Aug 05, 2010 12:59 pm

Re: High Monocytes, MCV, & MCHC

Postby juliej » Fri Sep 28, 2012 11:35 am

Those are all things that are elevated in Xeloda patients. The MCV (mean corpuscular volume) is used by some oncs as a dosage test - high means the patient is getting enough to be effective.

Hope this helps!
Julie
Stage IV, liver/lung mets 8/4/2010
Xelox+Avastin 8/18/10 to 10/21/11
LAR, liver resec, HAI pump 11/11
Double lung surgery + ileo reversal 2/12
Adjuvant Xeloda 3-9/12
VATS rt. lung 12/21/12 - benign granuloma!
NED 3/17/12 to 6/13/2019, CEA<1

Luck12

Re: High Monocytes, MCV, & MCHC

Postby Luck12 » Fri Sep 28, 2012 1:45 pm

Hi Julie,

Thanks for the info!

Roddy

mpbser
Posts: 910
Joined: Wed Apr 19, 2017 11:52 am

Re: High Monocytes, MCV, & MCHC

Postby mpbser » Tue May 07, 2019 4:00 pm

Juliej, curious about the comment you made about MCV as an indicator of adequate dosage -- do you have any details about this?

My husband's is in the normal range, so I hope that is not a sign he's not getting adequate dosage.
Wife 4/17 Dx age 45
5/17 LAR
Adenocarcinoma
5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
8/17 Sub-total colectomy
2nd tumor 5.5 cm T1 N0
lymph nodes: 9 of 96
CEA: 2.9 to 2.2
MSS/MSI-L
Lynch no; KRAS wild
Immunohistochemsistry Normal
Tumor: MTOR, APC, TP53
Fall 2017 FOLFOX shrank the 1 met in liver
1/18 Liver left hepatectomy seg 4
5/18 CT clear
12/18 MRI shows 1 liver met
3/7/19 Resection & HAI
4/1/19 Folfiri & FUDR
5/13/19 HAI pump catheter dislodge, nearly hemorrhaged to death
6/10/19 5FU

Beckster
Posts: 370
Joined: Thu Jan 12, 2017 3:01 pm
Location: New Jersey

Re: High Monocytes, MCV, & MCHC

Postby Beckster » Wed May 08, 2019 5:11 am

My monocytes, MCV and MCHC were all elevated above normal range....they went back down after Xeloda chemotherapy. Here are some links about MCV and Xeloda...

https://www.ncbi.nlm.nih.gov/pubmed/24659646
https://www.ncbi.nlm.nih.gov/pubmed/12569298
https://pdfs.semanticscholar.org/d4b6/f ... 0d8c96.pdf
57/Female
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Type: Adenocarcinoma
Tumor size:3.5 cm x 2.5 x 0.7 cm
Grade: G3 (path) G2 (pre-op)
TNM: T3N0M0/IIA
LN: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic reaction to oxaliplatin on first infusion
1/2/17 to 6/9/17- Xeloda monotherapy
6/17, 12/17, 6/18, 12/18, 6/19 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/18-3.1, 6/18-3.0, 9/18 2.8, 12/18 2.5 3/19 3.1 6/19 3.1
Clear Colonoscopy 10/17 :D

mpbser
Posts: 910
Joined: Wed Apr 19, 2017 11:52 am

Re: High Monocytes, MCV, & MCHC

Postby mpbser » Wed May 08, 2019 6:08 am

Thanks, beckster!
Wife 4/17 Dx age 45
5/17 LAR
Adenocarcinoma
5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
8/17 Sub-total colectomy
2nd tumor 5.5 cm T1 N0
lymph nodes: 9 of 96
CEA: 2.9 to 2.2
MSS/MSI-L
Lynch no; KRAS wild
Immunohistochemsistry Normal
Tumor: MTOR, APC, TP53
Fall 2017 FOLFOX shrank the 1 met in liver
1/18 Liver left hepatectomy seg 4
5/18 CT clear
12/18 MRI shows 1 liver met
3/7/19 Resection & HAI
4/1/19 Folfiri & FUDR
5/13/19 HAI pump catheter dislodge, nearly hemorrhaged to death
6/10/19 5FU

mpbser
Posts: 910
Joined: Wed Apr 19, 2017 11:52 am

Re: High Monocytes, MCV, & MCHC

Postby mpbser » Fri May 10, 2019 8:32 am

I finally had a chance to look at those links on Xeloda increasing MCV and its predictive value. Does this mean that if MCV stays the same, completely in the middle of the normal range, that the chemo (currently folfiri in my husband's case) may be at an adequate dosage or otherwise "isn't working"? From those articles, it seems that the higher the MCV, the better, during chemo. Always something to be worried about.......!
Wife 4/17 Dx age 45
5/17 LAR
Adenocarcinoma
5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
8/17 Sub-total colectomy
2nd tumor 5.5 cm T1 N0
lymph nodes: 9 of 96
CEA: 2.9 to 2.2
MSS/MSI-L
Lynch no; KRAS wild
Immunohistochemsistry Normal
Tumor: MTOR, APC, TP53
Fall 2017 FOLFOX shrank the 1 met in liver
1/18 Liver left hepatectomy seg 4
5/18 CT clear
12/18 MRI shows 1 liver met
3/7/19 Resection & HAI
4/1/19 Folfiri & FUDR
5/13/19 HAI pump catheter dislodge, nearly hemorrhaged to death
6/10/19 5FU

mpbser
Posts: 910
Joined: Wed Apr 19, 2017 11:52 am

Re: High Monocytes, MCV, & MCHC

Postby mpbser » Fri May 10, 2019 8:50 am

AND, as usual, I came across a confounder! https://www.ncbi.nlm.nih.gov/pubmed/28795308

This abstract confuses the heck out of me. "The multivariate analysis of the factors associated with the DFS showed that stage and MCV were significant factors; an MCV of <80 fL was associated with a superior DFS in comparison to an MCV of 80-100 fL (hazard ratio: 0.31, 95% confidence interval: 0.13-0.61, p = 0.0003). The DFS in patients with an MCV of <80 fL was superior to that in patients with an MCV of ≥80 fL, irrespective of whether the patients underwent postoperative adjuvant chemotherapy." Normal range is 80-100, but DFS in patients with an MCV of <80 was superior to that in patients with an MCV of ≥80 (normal)??? So bizarre, really.
Last edited by mpbser on Fri May 10, 2019 9:04 am, edited 1 time in total.
Wife 4/17 Dx age 45
5/17 LAR
Adenocarcinoma
5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
8/17 Sub-total colectomy
2nd tumor 5.5 cm T1 N0
lymph nodes: 9 of 96
CEA: 2.9 to 2.2
MSS/MSI-L
Lynch no; KRAS wild
Immunohistochemsistry Normal
Tumor: MTOR, APC, TP53
Fall 2017 FOLFOX shrank the 1 met in liver
1/18 Liver left hepatectomy seg 4
5/18 CT clear
12/18 MRI shows 1 liver met
3/7/19 Resection & HAI
4/1/19 Folfiri & FUDR
5/13/19 HAI pump catheter dislodge, nearly hemorrhaged to death
6/10/19 5FU

Gravelyguy
Posts: 169
Joined: Thu Jul 05, 2018 6:03 pm

Re: High Monocytes, MCV, & MCHC

Postby Gravelyguy » Fri May 10, 2019 8:55 am

FWIW I just went back and checked my MCV values while on Folfox and it was always in the normal range and the Folfox seemed to do its job so I would not worry about it.

Dave
6/17 dx mCRC t3n1m1 very low rectal tumor 2 liver Mets 1.3 cm and .9 cm

6/17 begin 4 rounds Folfox w/Vectibix
9/17 short course radiation
10/17 rectal and liver resection LAR with coloanal anastomosis (no rectum left)
11/17-3/18 8 rounds Folfox
6/18 still NED!! Takedown
8/28/18 still NED! CEA .8 new low for me
10/18/18 colonoscopy clear
12/12/18 clear scans, CEA .9 still NED!
6/11/19 clear scans CEA 1.0

mpbser
Posts: 910
Joined: Wed Apr 19, 2017 11:52 am

Re: High Monocytes, MCV, & MCHC

Postby mpbser » Sat May 11, 2019 5:37 am

Thanks, gravelyguy. I hope that whatever predictive factor MCV has is just like pretty much every other biomarker there is, e.g. CA19-9, CEA, LD, which don't necessarily tell much for some people.
Wife 4/17 Dx age 45
5/17 LAR
Adenocarcinoma
5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
8/17 Sub-total colectomy
2nd tumor 5.5 cm T1 N0
lymph nodes: 9 of 96
CEA: 2.9 to 2.2
MSS/MSI-L
Lynch no; KRAS wild
Immunohistochemsistry Normal
Tumor: MTOR, APC, TP53
Fall 2017 FOLFOX shrank the 1 met in liver
1/18 Liver left hepatectomy seg 4
5/18 CT clear
12/18 MRI shows 1 liver met
3/7/19 Resection & HAI
4/1/19 Folfiri & FUDR
5/13/19 HAI pump catheter dislodge, nearly hemorrhaged to death
6/10/19 5FU


Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”



Who is online

Users browsing this forum: No registered users and 32 guests