Calling ALL Colorectal CANUCKS !

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CRguy
Posts: 9318
Joined: Sun Feb 10, 2008 6:00 pm

HAPPY CANADA DAY 2017 Canucks !

Postby CRguy » Sat Jul 01, 2017 5:13 pm

Wishing all our Canuckians on board a very happy Canada 150th !!!!!!

Cheers and Harmony moving forward for the next 150

CRguy
Caregiver x 3
Stage IV A rectal cancer/lung met
10 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

justin case
Posts: 4186
Joined: Sun Sep 04, 2011 8:26 am
Location: Katy, Texas

Re: Calling ALL Colorectal CANUCKS !

Postby justin case » Wed Jul 05, 2017 4:31 pm

Enjoy your holiday my friend 8)
bro Nut
7/11 diagnosed Stage 2 colon and rectal cancer
chemo/rad
lar/temp ilio
Reversal & port removal
21 round of chemo Folfox 9tx, 5fu 12 tx
Last treatment July 2012

Steph20021
Posts: 503
Joined: Sat Dec 27, 2014 4:58 pm
Location: Ontario, Canada

Re: Calling ALL Colorectal CANUCKS !

Postby Steph20021 » Thu Jul 06, 2017 12:20 am

I recently returned from a camping trip to Bruce Penninsula National Park in Tobermory. Saw the five, the grotto and flowerpot island. Amazing beauty! Highly recommend it if you haven't been!
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, hysterectomy et al, 2nd temp ileo, NED?
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
Jan/17- pulmonary embolism
Feb/17- 1 wk radiation to abdo wall
Currently stable suce Aug/16- on folfiri

henry123
Posts: 28
Joined: Sun Oct 08, 2017 3:25 am

Re: Calling ALL Colorectal CANUCKS !

Postby henry123 » Sun Oct 08, 2017 4:50 am

Hello
Is there any update for approval of Keytruda or Opdivo for msi-H CrC by Health Canada now that it has been approved by FDA in USA?
What sort of time lag is there normally for such approvals.
Regards.
Henry
46yo M
5/16 lap AR 14/21 L nodes +ve
T4N2M1
cea 80
6/16 Ext Rt hemicolectomy
7/16 Capox 9 cyc
9/16 cea 2
1/17 cea 550
pet shows mets in lung & peri
iri+ avastin failed
3/17 cea 10577
msi-high, lynch+ve
4/17 regro failed
5/17 cea 28800
5/17 CT increase in size of mesentric nodes , new onset of multiple nodules in liver.
6/17 Opdivo start
7/17 cea 26754
8/17 5623
9/17 497
10/17 52
11/17 12
CT shows all clear exc a nodule in Lung. liver normal
opdivo to continue
Vegan+ yoga +juicing +apricot seeds

User avatar
CRguy
Posts: 9318
Joined: Sun Feb 10, 2008 6:00 pm

Re: Calling ALL Colorectal CANUCKS !

Postby CRguy » Sun Oct 08, 2017 12:43 pm

Welcome to CTalk Henry
that is a million$$$$ question regarding HC !

depending upon provincial "rules" and how they play into overall HC regs....
there may be some access under compassionate care / experimental release IF there is a particularly good, pro-active and aggressive doctor in the loop who can navigate the systems for you... and this would apply to all "new" treatments and drugs.

IME ... each province / cancer center etc. seems to be its own minefield OR field of dreams depending upon the factors mentioned.

Specifically though, a September 27, 2017 announcement Keytruda Approved as First-Line Lung Cancer Treatment in Canada states a specific use acceptance for one application :
“Lung cancer is the leading cause of cancer death for both men and women in Canada, which makes this new indication especially significant. We look forward to working with provinces and other jurisdictions to ensure that Canadians who need immunotherapy for first-line treatment of metastatic NSLC have rapid access to Keytruda,” Chirfi Guindo, president and managing director of Merck Canada (known as MSD outside the U.S. and Canada),


How quickly this availability will translate to other indications is anybody's guess.

ANY OTHER Canucks with any other info please chime in !

Cheers
CRguy
Caregiver x 3
Stage IV A rectal cancer/lung met
10 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

henry123
Posts: 28
Joined: Sun Oct 08, 2017 3:25 am

Re: Calling ALL Colorectal CANUCKS !

Postby henry123 » Mon Oct 09, 2017 1:36 am

CRguy wrote:Welcome to CTalk Henry
that is a million$$$$ question regarding HC !

CRguy


Thanks CRguy.
46yo M
5/16 lap AR 14/21 L nodes +ve
T4N2M1
cea 80
6/16 Ext Rt hemicolectomy
7/16 Capox 9 cyc
9/16 cea 2
1/17 cea 550
pet shows mets in lung & peri
iri+ avastin failed
3/17 cea 10577
msi-high, lynch+ve
4/17 regro failed
5/17 cea 28800
5/17 CT increase in size of mesentric nodes , new onset of multiple nodules in liver.
6/17 Opdivo start
7/17 cea 26754
8/17 5623
9/17 497
10/17 52
11/17 12
CT shows all clear exc a nodule in Lung. liver normal
opdivo to continue
Vegan+ yoga +juicing +apricot seeds

mozart13
Posts: 102
Joined: Fri Dec 09, 2016 7:38 pm
Location: Toronto

Re: Calling ALL Colorectal CANUCKS !

Postby mozart13 » Tue Oct 10, 2017 8:57 am

Henry, here is the link about Keytruda, not sure if it answers your question:
https://lungdiseasenews.com/2017/09/26/ ... ed-canada/

Steph20021, last summer I went to Tobermory, what a beutyfull place, pristine water, one could see those shipwrecks that went down in 1885, islands are geourges, a lots of hiking possibilities.
Last summer was very hot, but lake was refreshing, went swimming few times, my younger one loved it.
55 year, male, never been seek in my life.
Diagnosed with T1,T2 N0 M0 rectal cancer, tumor 4.5cm,
Stage 1
CEA 2.0
Discovered by pure lack, after taking baby ASA, had blood in stool.
25 sessions of Chemo/rad finished end of January 2017, focus was on lymph nodes
Tumor erased, CCR, negative mri, ct, scope, no evidence of cancer
W&W approach 8)
April 2017, folfox 8 rounds plus 2 rounds of xeloda
Sept.2017 CT , MRI negative

henry123
Posts: 28
Joined: Sun Oct 08, 2017 3:25 am

Re: Calling ALL Colorectal CANUCKS !

Postby henry123 » Thu Oct 12, 2017 2:21 am

mozart13 wrote:Henry, here is the link about Keytruda, not sure if it answers your question:
https://lungdiseasenews.com/2017/09/26/ ... ed-canada/

Steph20021, last summer I went to Tobermory, what a beutyfull place, pristine water, one could see those shipwrecks that went down in 1885, islands are geourges, a lots of hiking possibilities.
Last summer was very hot, but lake was refreshing, went swimming few times, my younger one loved it.

Thanks
46yo M
5/16 lap AR 14/21 L nodes +ve
T4N2M1
cea 80
6/16 Ext Rt hemicolectomy
7/16 Capox 9 cyc
9/16 cea 2
1/17 cea 550
pet shows mets in lung & peri
iri+ avastin failed
3/17 cea 10577
msi-high, lynch+ve
4/17 regro failed
5/17 cea 28800
5/17 CT increase in size of mesentric nodes , new onset of multiple nodules in liver.
6/17 Opdivo start
7/17 cea 26754
8/17 5623
9/17 497
10/17 52
11/17 12
CT shows all clear exc a nodule in Lung. liver normal
opdivo to continue
Vegan+ yoga +juicing +apricot seeds

Steph20021
Posts: 503
Joined: Sat Dec 27, 2014 4:58 pm
Location: Ontario, Canada

Re: Calling ALL Colorectal CANUCKS !

Postby Steph20021 » Thu Oct 12, 2017 9:09 pm

Tobermory is such a beautiful area!!!

mozart13 wrote:Henry, here is the link about Keytruda, not sure if it answers your question:
https://lungdiseasenews.com/2017/09/26/ ... ed-canada/

Steph20021, last summer I went to Tobermory, what a beutyfull place, pristine water, one could see those shipwrecks that went down in 1885, islands are geourges, a lots of hiking possibilities.
Last summer was very hot, but lake was refreshing, went swimming few times, my younger one loved it.
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, hysterectomy et al, 2nd temp ileo, NED?
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
Jan/17- pulmonary embolism
Feb/17- 1 wk radiation to abdo wall
Currently stable suce Aug/16- on folfiri

User avatar
Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Calling ALL Colorectal CANUCKS !

Postby Maia » Tue Oct 17, 2017 1:35 pm

Canadians: the opportunity of receive ''a targeted therapy drug that is specific to an abnormal gene change in their cancer''. A Canadian TAPUR: CAPTUR
No locations disclosed but for sure Toronto and Vancouver.

NCT03297606
For BRAFV600: BRAF inhibitor + MEK inhibitor.
For those with high mutational burden, POLE, POLD1 --I'm assuming: also for MSI-H--: immunotherapy: nivo + ipi

https://clinicaltrials.gov/ct2/show/NCT03297606

User avatar
CRguy
Posts: 9318
Joined: Sun Feb 10, 2008 6:00 pm

Re: Calling ALL Colorectal CANUCKS !

Postby CRguy » Tue Oct 17, 2017 4:18 pm

Thanks Maia
Yes with these 2 involved there WILL be YVR and T.O. for sure !
Investigators
Study Chair: Lillian Siu Univ. Health Network-OCI/Princess Margaret Hospital, Toronto, ON Canada
Study Chair: Daniel J Renouf BCCA - Vancouver Cancer Centre, Vancouver BC, Canada

With the "kitchen sink" of medications for their study groups, they are basically cataloguing these different treatments' effects within given
investigational arms .... just IMO ... for future referencing of possible novel treatments with known agents, for nonstandard uses.
While the list mainly targets hemolymphatic cancers, the inclusion of Advanced Solid Tumors opens the door for others.

The POG program really kick started a whole new brain trust at BCCA Vancouver and FYI a lot of the Foundation fundraising has been promoting immunotherapies as well as this type of targeted therapy research. ANY cancer Tx advancements will ultimately benefit other fields of research and treatment.

GOOD things to come for Colorectal Canucks ... close to home.

Cheers
CR
Caregiver x 3
Stage IV A rectal cancer/lung met
10 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far


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