Has anyone on folfox treated with vitamin B6 for neuropathy experienced increased and/or asymmetric pheripheral neuropathy in an acute time period?? (only right hand/ foot numbness and is mostly palmar and plantar surfaces).
My husband had completed one cycle folfox then he started on B6 100mg bid for next two weeks but on some days was getting 250mg plus B6 per day because of B complex that he took maybe 6 days of 14 days. Med-Onc ordered head MRI for Monday because of symptoms being asymmetric. Carl has had a mild headache on most evenings (which could be explained by chemo, stress.....) but definitely no more neurological deficits. The neuropathy is purely sensory at this point, no motor deficits. I realized since we came home from 3rd cycle Tuesday that it may be B6 toxicity. I did some reading and learned that B6 toxicity can come on within days AND it can be asymmetric (Medscape info). I held the B6 for 3 days and the numbness is getting better. We will restart at lower dose??? I had read that 100mg/day is the upper safe limit.....Is this true???
Thanks for your input!!!