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Rectum Transplant can it be done?

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Rectum Transplant can it be done?

Postby rickker20 » Mon Jan 24, 2011 12:34 am

You hear about heart and kidney transplants but have there been a Rectum transplant? Can it be done? If you lost your rectum to cancer can you attached one? I think it would be very painfull surgery.
Rectal Cancer 6/09
Stage 1 T2
9 days of 5fu
2 days of Avastin
5 weeks of Radiation
Lar 9/09 failed
Pull thru surgery 10/09
Rectum Removel,38 lymph nodes remove all cancer free
6 weeks of 5fu & Folfox
Bag reversal 6/10 & Port remove
Cancer free
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Re: Rectum Transplant can it be done?

Postby Surroundedbylove » Mon Jan 24, 2011 8:45 am

We effectively have that with colonic j-pouches and ileal j-pouches. These are both replacements for the rectum made out of part of the colon or part of the ileum. However, the issue is the anal sphincter muscles. If the rectal tumor is too low, then the surgeons can't get adequate margins and preserve the anal sphincter muscles. The anal sphincter muscles are basically what give us all control.
Surroundedbylove

Rectal Cancer @ 43, '08
Clinical: T3,N2a,MX (IIIB)
6 wks XELOX & radiation
LAR, colonic j-pouch, & temp ileo '09
Surgical: ypT3,ypN0,ypMX (0 of 20 nodes)
FOLFOX; XELOX
Ileo Takedown '09
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Re: Rectum Transplant can it be done?

Postby BrownBagger » Mon Jan 24, 2011 9:33 am

I don't know. Just before my surgeon put me under for my first surgery, he mentioned that he "just finished building a new rectum for another guy." I'm sure he was talking about more than just a j-pouch, which is what he gave me. I probably have a third of my rectum left. I've never heard of a rectal transplant, but I think based on what he said that some kind of total reconstruction surgery is possible.
Eric, 55
Dx RC 3/09
Chem/Rad
LAR, temp ileo 6/09, rev. 8/09
4 Rnd Xelox
Mis-dx 2a, 6/09. Dx Stg 4a, 8/10.
T3, N 0/18, M1
Thoracotomy (r) 10/10
2 lung mets dx 6/11
Thoracotomy/lobectomy (l), VATS (r) 3/14/12
Erb/Iri 5/12-9/12
Bicycle miles post-dx 10,189
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Re: Rectum Transplant can it be done?

Postby Lee » Mon Jan 24, 2011 10:33 am

I believe it is possible to recreate a rectum using "parts", but I have not heard of a rectum transplant. I had all of my rectum removed during my surgery, I knew I would be waking ups with a perm colostomy. Sometimes I think it would be nice to "poop" the old fashion way and wonder if something can be done. But also know I probably would not do anything about it. I had serious bathroom issued as a result of radiation, my colostomy gave me my life back and I don't want to go down that path of no rectal control again.

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004
permanent colostomy
chemo - FOLFOX
NED - 9 years and counting!
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Re: Rectum Transplant can it be done?

Postby Terry » Mon Jan 24, 2011 2:59 pm

I have never heard of a rectum transplant.
DX 7/3/07
Chemo, radiation, 20 mo. chemo, IMRT, cyberknife, 6/11 lobectomy.
1/16 resection perm. colostomy intraop. rad.
PET 2/12 nose, thyroid, liver, lngs
Folfox 3/12
Lord I know You'll keep me here until
you know I cannot suffer any longer!
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Re: Rectum Transplant can it be done?

Postby wifeandmom » Mon Jan 24, 2011 3:04 pm

I actually asked my surgeon that very question! If I understood him correctly, he said that "rectum transplants" are not done because the area has so much necessary immune activity (lots of lymph nodes? idk --- I didn't ask a lot of questions) that the chance of rejection would be unacceptably high. He said that transplants are usually reserved for life-saving procedures (again, I didn't ask him about things like cornea transplants). I wonder if someday scientists will find a way to "grow" a new rectum from a person's own stem cells ..........
Dx 4/09
Rectal CA T3 N0 M0
Neo-adj. rad/Xelox
Surgery 8/25/09 LAR, temp ileo
Reversal 10/09
Fistula
Surgery 12/21/09 temp ileo
ICU 12/30/09
8 rounds Xelox
Surgery 9/9/10 fix fistula, redo anastomosis
Reversal surgery 12/23/10
Hernia surgery 5/19/11
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Re: Rectum Transplant can it be done?

Postby 74bravo » Mon Jan 24, 2011 5:23 pm

I honestly don't think that the ability to regenerate is off in the too distant future. They are working now on printing organs (just a theory right now...but it's a step in the right direction). If you look here http://www.medgadget.com/archives/2005/04/inkjet_printing.html you will see at the least they were working on it. There are some newer links where they are printing skin grafts and the like and being grown in a lab setting http://www.medgadget.com/archives/2010/11/in_situ_skin_bioprinting_for_burn_wounds.html, so I think once they get this worked out that it won't be long before they advance.
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Re: Rectum Transplant can it be done?

Postby weisssoccermom » Mon Jan 24, 2011 7:43 pm

As others have said, I'm not sure why the medical community would even consider researching this question when they have other solutions which are equally viable.

Question Rickker as to your signature.
Were you dxd as a stage I?? I don't understand why, if being dxd stage I, you would get 2 days of Avastin - any Avastin at all for that matter. It's not a drug that is approved or even indicated for stage II much less stage I. Why only 9 days of 5FU??
Why FOLFOX after surgery??
6/22/06 IIA rectal cancer
6 wks rad/Xeloda
1st attempt transanal excision 11/06
11/17/06 XELOX 1 cycle
5 mths Xeloda only - blood clots 1/07
transanal excision 4/20/07 path-NO CANCER CELLS!
NED now and forever!
Perform random acts of kindness
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