Personally I think Xeloda and 5FU pale beside Japan's UFT(tegafur-uracil) and S-1 or TS-1 formulas with the DPD inhibitors. UFT is now an inexpensive generic, available in most countries, outside of the US.
An amazing paper is Matsumoto (2002) with high 10 year survival using continuous oral 5FU plus cimetidine in new, advanced colorectal cancer cases with CA19-9 biomarker. Japan has since replaced continuous oral 5FU with tegafur based UFT and TS-1.
Based on my reading of papers, UFT appears to have the least side effects (much lower) and (T)S-1 is probably hotter on cancer kill, but still less side effect than Xeloda. My spouse has been on UFT (300 mg tegafur) continuously for two months, no breaks, not one day off. CEA is declining nicely (well under 3), WBC were declining, added a recommended herbal tea from a top board scoring MD, WBC back up. The Japanese (and Koreans and Chinese) have a series of studies with UFT+cimetidine and UFT+PSK.
I went to an oncologists meeting. Roche had more than one salesman per doctor, extra salemen waiting in the wings. Roche seems to own or employ a lot of the oncologists where we stay. Everyone was pushing XELOX or FOLFOX + 1-2 biologicals. Once I realized UFT was available locally, we dumped them, went with prof that had UFT experience.
There are several Japanese case studies on hopeless epithelial cancer cases, including mCRC, that use continuous UFT+cimetidine+PSK for up to 3 years with long term survival.
Spouse started 1600 mg cimetidine, 10,000-15,000 iu vit D3, 900 mg lipoic acid, 600 mcg MeSC selenium, 500 mg coQ10, fish oil, 45mg vit K2(MK4), 4000 mg vit C, 2000 mg N-acetylcysteine(NAC), vit E-succinate, pancreatin daily - for 1 month before surgery. Added 10-60mg vit K3 and IV vitamin C (25,000-75,000 mg/infusion, 3-7 times/week) after surgery and reduced cimetidine to 800mg after 2 months. No serious side effects, perhaps Grade 1 diarrhea sometimes from the UFT, we go out a lot. Spouse was able to walk out of hospital 3 days after surgery. 6 oncologists say micrometastatic CRC case with possible lung mets less than 1 cm.
Spouse dx'd March with obstructive colon cancer, prospective stage III/IV.
1 month of alt chemotherapy and nutritional fortification before surgery (was initially a marginal surgical candidate).
Highly experienced surgeon laid in multiple metal clips for radiation on non-resectable invaded area.
However, pathology showed most invasive material outside colon necrosed before surgery, obstructed channel opened slightly, 2 lymph nodes remained positive.