You are not the first person to tell me that I am thinking too far into the future. I wish that it were so easy for me to do that. As long as someone can help me feel that a decision I make now won't mean that I am limiting my options for the future I will try very hard to learn how to do that.

Wow. Your post gives me a lot to think about. If those numbers are true, then the stats for liver resection are higher/ more positive than the stats for those with an HAI pump. So here's a question. Yesterday a surgeon told me that a partial resection and HAI pump would put my 5-year survival rate b...

I always ask the human doctor. I just wish that the human doctor would tell me WHY something I bring up does or does not apply instead of just dismissing me outright. I am data driven and explanations are important to me, but sometimes I feel like asking for those can be a tall order.

Sending you vibes for a positive outcome.

So I am back from two days of second opinions from the James in Columbus OH (ranked #20 nationally). I am locally receiving treatment from a center in Dayton. As they say, you get what you ask for. Now I have some decisions to make- especially with regard to surgical options. Liver mets: My highly r...

Thank you for your replies. This had me up in the middle of the night so I tried a different search methodology. Instead of looking for G12V + Avastin, which gets me to a study titled "G12V and G12A KRAS mutations are associated with poor outcome in patients with metastatic colorectal cancer tr...

I met with a medical oncologist today who is considered to be a specialist in genomic testing and research. He told me today that a KRAS G12V mutation does not rule out Avastin. Yet a quick Google search shows qualified studies that say differently. What do you think? The Onc can't be wrong, can he?...

I'm a fairly intelligent person, but honestly this exhausts me. For what it's worth, I have my own genetic tests and have run those through studies and my personal genes turn up bad for Avastin and Cetuximab as well. Because of that, I sort of anticipated this coming but still had hope since my Onco...

I'm still trying to fathom HOW I have so many mutations when I know no-one else in my family that has had CRC. As far as Cancer, my uncle had Prostate cancer, his daughter has low-stage melanoma but that is it. Heck, my mother was an alcoholic, anorexic and bulimic, which drove osteoporosis anaemia ...

KRAS G12V NRAS Wild type MS-Stable Tumor Mutational Burden 5 Muts (low) APC R302 APC E1408 CCDN amplification ERBB amplification TP53 R273C VEGFA amplification Some of these are very rare. The VEGFA amplification is present in only 3 percent of CRC cases and is associated with higher stage, tumor gr...

Thank you for sharing. What is the typical scanning and monitoring schedule after reaching NED? I read that most CRC recurrences are in the second year after diagnosis, so logic would follow that scanning should be pretty frequent up until the 2-year mark at least, correct?

Welcome to the club. I am glad that you are getting a lot of opinions and using resources available. I am hoping that you can get to a path to NED.

Welcome to the club. I hope that that the Mayo Clinic has a plan for you. Please check in with us to let us know how things go. I got admitted to the hospital and had a resection due to Colon blockage (I actually went to an ER with what I thought was a stomach bug). I still didn't find out that Ihad...

I guess I will talk to my oncologist about it tomorrow, and hope that his eyes don't roll too far up into his head like they have in the past when I reference my genetic testing.

We'll also see what his tests say. Honestly, with liver mets I am terrified about my prognosis if we can't use Avastin.

I have just finished my first round of Oxy+ 5FU. Got unhooked Friday at lunch. No diarrhea, but actually was constipated all day yesterday. Is that normal? I expected goo and got the opposite? Or is the goo still on it's way?