I tried all the anti-nausea drugs prescribed, nothing worked for me except cannabis. I held off trying it for a couple of months, then, when all else had failed it worked! I was finally able to eat!!
I also had low, stage 3c rectal with 7 positive lymph nodes. I had 8 rounds follow-up Folfox Nov-Dec '14. I was very sick the entire treatment time and still have a lot of hand and feet issues, given the circumstances would likely do it all over again as it seemed the best for me.