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by DK37
Sat Dec 03, 2016 6:28 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: A Potential MSS-CRC Immunotherapy From an AIDS Drug Start: The CCR5 Receptor Antagonist Maraviroc
Replies: 11
Views: 5852

Re: A Potential MSS-CRC Immunotherapy From an AIDS Drug Start: The CCR5 Receptor Antagonist Maraviroc

I tried to get my integrative doctor to prescribe off-label Maraviroc to me, but he stongly advised against it. Normally he has been supportive for off-label use of other drugs, such as metformin. He said the FDA requires the manufacturer to label the boxes with the ominous black box warning, in th...
by DK37
Mon Nov 28, 2016 8:50 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: DK37 Blog - The Times They are a Changin'
Replies: 11
Views: 3436

DK37 Blog - The Times They are a Changin'

My new blog post as I do a final FOLFIRI chemo infusion this morning & prepare for the world of Phase 1 CRC Clinical Trials. "The Times They are a Changin'" https://adventuresinlivingterminallyoptimistic.com/2016/11/28/the-times-they-are-a-changin/ Excerpts: Taken all together – it is ...
by DK37
Mon Nov 21, 2016 5:57 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: A Potential MSS-CRC Immunotherapy From an AIDS Drug Start: The CCR5 Receptor Antagonist Maraviroc
Replies: 11
Views: 5852

Re: A Potential MSS-CRC Immunotherapy From an AIDS Drug Start: The CCR5 Receptor Antagonist Maraviroc

WHOA! Thanks for highlighting this study. I have an appointment lined up with NCT in Heidelberg the week after next. Initially it was only meant as a general discussion whether they will take me in as their patient (I really need an oncologist or even better an oncological team that has a treatment...
by DK37
Sun Nov 20, 2016 5:23 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: A Potential MSS-CRC Immunotherapy From an AIDS Drug Start: The CCR5 Receptor Antagonist Maraviroc
Replies: 11
Views: 5852

Re: A Potential MSS-CRC Immunotherapy From an AIDS Drug Start: The CCR5 Receptor Antagonist Maraviroc

Very interesting. and given toxicity, clinical response, and approved med, this may be better option than trials as first option following conventional chemo. Any duration reported study? Edit: I missed the data the first read through. Keep in mind this is in VERY small patient numbers, here is the...
by DK37
Sun Nov 20, 2016 11:36 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: A Potential MSS-CRC Immunotherapy From an AIDS Drug Start: The CCR5 Receptor Antagonist Maraviroc
Replies: 11
Views: 5852

A Potential MSS-CRC Immunotherapy From an AIDS Drug Start: The CCR5 Receptor Antagonist Maraviroc

Today’s Blog Post is a science one – but one I recommend all MSS-CRC patients read and consider discussing with their MD/medical team for medical advice: “A Potential MSS-CRC Immunotherapy From an AIDS Drug Start: The CCR5 Receptor Antagonist Maraviroc” Some excerpts: This study was very small, only...
by DK37
Sat Nov 19, 2016 9:07 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Peri Mets / MSS-CRC Immunotherapy Trial (Oncolytic Virus + anti-PDL1)
Replies: 3
Views: 3271

Peri Mets / MSS-CRC Immunotherapy Trial (Oncolytic Virus + anti-PDL1)

PERITONEAL MET PATIENTS: I know there has been a lot of interest in the oncolytic virus + PD(L)1 inhibitor strategy after I recently signed up for the NCT02636036 trial. I also wanted to post this because peri mets can be resistant to chemotherapy. It is one experimental strategy to try to convert a...
by DK37
Thu Nov 17, 2016 4:33 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New MSS-CRC PD1 Immunotherapy Trial in MINNESOTA
Replies: 6
Views: 3841

Re: New MSS-CRC PD1 Immunotherapy Trial in MINNESOTA

I'm new to this board, but want to thank you for all the information you have provided. My mom has metastatic colon cancer and has been told she is out of options other than clinical trials. Her doctor offered the MATCH trial, but I've been doing a lot of reading on the immunotherapy trials. Do you...
by DK37
Sun Nov 13, 2016 4:20 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Philly Inquirer Column: A Personal Medical Update & Advocacy for Proactive Clinical Trial Monitoring Before "Needed"
Replies: 6
Views: 1371

Re: Philly Inquirer Column: A Personal Medical Update & Advocacy for Proactive Clinical Trial Monitoring Before "Needed"

DK37 Do you know if there are still openings in your trial? BTW I met Phuong at the Orange County "Get Your Rear in Gear", she is a sweetheart, took a few pictures and will post them soon... Best wishes, good luck and many prayers for you... Hi Pita, Last I heard they were taking names fo...
by DK37
Sun Nov 13, 2016 3:53 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Philly Inquirer Column: A Personal Medical Update & Advocacy for Proactive Clinical Trial Monitoring Before "Needed"
Replies: 6
Views: 1371

Re: Philly Inquirer Column: A Personal Medical Update & Advocacy for Proactive Clinical Trial Monitoring Before "Needed"

At the risk of being trite, may I just say ..... " These are the voyages of the intrepid explorer DK37... to boldly go where no one has gone before." You carry our own hopes with you my friend and are always in our hearts and minds. Always in Harmony with you on your ongoing Journey CRguy...
by DK37
Sat Nov 12, 2016 8:00 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Philly Inquirer Column: A Personal Medical Update & Advocacy for Proactive Clinical Trial Monitoring Before "Needed"
Replies: 6
Views: 1371

Philly Inquirer Column: A Personal Medical Update & Advocacy for Proactive Clinical Trial Monitoring Before "Needed"

Hi Everyone, I wanted to post a link to my most recent column for the Philadelphia Inquirer "Chemo is no longer killing my cancer. Here's why I still have hope." http://www.philly.com/philly/blogs/diagnosis-cancer/Chemo-is-no-longer-killing-my-cancer-Heres-why-I-still-have-hope.html In ter...
by DK37
Tue Nov 08, 2016 4:10 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Big New MSS-CRC Immmunotherapy Trial: anti-CD47
Replies: 9
Views: 5182

Re: Big New MSS-CRC Immmunotherapy Trial: anti-CD47

I'm confused about the use of Cetuximab with KRAS mutant CRC in this trial. Is the thought that the CD47 will circumvent the process that causes the poor prognosis that is associated with the use of Cetuximab with KRAS? Hi KElizabeth, KRAS-mutant tumors still have EGFR receptors for Erbitux to bind...
by DK37
Sun Nov 06, 2016 10:15 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Big New MSS-CRC Immmunotherapy Trial: anti-CD47
Replies: 9
Views: 5182

Re: Big New MSS-CRC Immmunotherapy Trial: anti-CD47

Thanks muchly for sharing! Could you briefly expand on the limited safety window, please? Is it because all cells have/express CD47 and the trial drug will also go after the healthy cells? CD47 is expressed by normal cells as well although it is up-regulated by tumors which is hoped to present a sa...
by DK37
Fri Nov 04, 2016 6:22 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Big New MSS-CRC Immmunotherapy Trial: anti-CD47
Replies: 9
Views: 5182

Big New MSS-CRC Immmunotherapy Trial: anti-CD47

BIG new immunotherapy clinical trial just announced for MSS CRC! We'll actually be a lead solid tumor indication for one of the hottest immunotherapy targets: anti-CD47 (if you google it you'll see many hits). CD47 is a "don't eat me" signal sent to macrophages - the drug blocks it from do...
by DK37
Thu Oct 20, 2016 8:29 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Roche MSS-CRC Immunotherapy Trial Data Pending
Replies: 1
Views: 781

Roche MSS-CRC Immunotherapy Trial Data Pending

A number of MSS-CRC recruiting trials have been announced to have clinical trial data release almost ready for analysis and 1H2017 release. https://twitter.com/AndyBiotech/status/ ... 8818305024

-DK
by DK37
Sun Oct 16, 2016 4:39 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: DK37's First MSS-CRC Immunotherapy Clinical Trial (Oncolytic Virus + PD1)
Replies: 7
Views: 4061

DK37's First MSS-CRC Immunotherapy Clinical Trial (Oncolytic Virus + PD1)

A very exciting medical update - I was just approved for my first immunotherapy clinical trial! It is a mixture of an oncolytic virus + PD1 inhibitor. The full story and how it fell unexpectedly into my lap at the link! https://adventuresinlivingterminallyoptimistic.com/2016/10/14/my-very-own-city-o...

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