Great Big Thumbs Up! Keep on doing what you are doing!

Best Regards,

GrouseMan

Grouseman - Thank you very much for your excellent reply with clarifications. As always, I appreciate your input on this Forum whenever you have the time to check in here and post your thoughts. (NB. Most of my comments in previous posts were based on internet searches that included 'colorectal can...

1. Avastin is always used in conjunction with other chemotherapy medications in either a 2-, 3-, or 4- drug combo. It is never used alone as a single-agent therapy. This is not quite correct. It is used in Opthomology to treat Macular Degeneration under another name and formulation. 2. Avastin appa...

The Erbitux rash is quite the irritant, and happens with all EGFr inhibitors, MABS as well as small molecule drugs in that class. I was involved in developing this class of anticancer drugs off and on for some time in the late 80's through the 90's. The first such drug was called Canertinib (CI-1033...

This link might be useful to you. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440160/ Its a subtype of Colon Cancer, Many people with Lynch Syndrome present I think with this. Its treated about the same as other Colon cancers, but might be a candidate for Checkpoint inhibitors due to its MSI statu...

There was a period where my wife's Oncologist dropped the 5-FU from Folfiri + Avastin. My wife thought that was a piece of cake. It was the 5-FU that gave her the most problem. She was taking Irinotecan, Erbitux and (probably Avastin - it was a trial w and - without she was pretty sure she was getti...

Well - Thanks for the boost in ratings :D - I wish this were not the case. Some of the folks here are coming thru Stage IV colon cancer better these days than when my wife was diagnosed in 2013. I remember back in those days on the forum we lost a lot of dear folks that had been diagnosed with late ...

I lived in a community of Finish folks in the UP of Michigan. Fins love their saunas!! Their philosophy is if Vodka, Coal Tar or Sauna doesn't cure what ails you nothing will! Take that philosophy and spend as much time enjoying that activity as you can. I've certainly enjoyed some epic sauna's sess...

We are not doctors and can't really provide advice on your treatment. All we can do is provide information about our own history and treatments. Some like myself also provide information about the drugs used and side effects, maybe some insights on currently evolving research to watch out for. We ar...

Congratulations on the recovery and continued response to Keytruda. This brings to mind some research I've read in the last month or so concerning turning tumors that are infiltrated with immune cells and resistant to them had high activity of the gene monoamine oxidase A. This is the gene that prod...

I saw a recent comment at In the Pipeline that I thought must have been from you. I think the mechanism of action of oxaliplatin is also not what they thought initially. Maybe this will lead to "designer" versions, and to better understanding of mechanisms of resistance. Nope wasn't me. I...

Well 5-FU has been around for over 50 Years. Almost if not everyone on this forum has most likely experienced its use. Seems its not too old a drug to determine more about its function and maybe learn more about ways it might be able to be applied or enhanced through the use of these other recently ...

Well said Catstaff! I would go on to say that almost always the mix of mutations in a Met is different than it was in a primary. That's why its important to get biopsies of Mets if possible to help direct chemotherapy or Immunotherapies. Your primary could have been removed and gene tested, but that...

How was the report for his CEA? I sent a private message to you and would like to further discuss a few things if you have the time of some clinical trials that are pending and what your husband has tried if that would be ok? I’m also confused on the typing KRAS G12D vs G12A (which was on my mom’s ...

It seems as though you have exhausted anything that had shown signs of slowing this Sh** down. My wife did a trial but at the end of it there wasn't much else available. She retired from work at that point in January and spent the few final months enjoying the time she had left. Though here it was w...