Great to see you back! Hope you're still livin' large. I've been holding on and slowly getting worse myself. I hope you'll find another trial that works, or a tolerable maintenance regimen.

Old timers of the world, unite!

All best, jdepp

Dear Lins, I'm sorry to hear about your husband's diagnosis. I wanted to say that his story almost matches mine exactly. In 2008 I was diagnosed (at 41) with stage 4 colon cancer (sigmoid) and inoperable liver metastases (12+). Throw in 19/ 28 infected lymph nodes, a pathology of poorly differentiat...

Welcome back, Deb. I agree with you: the chemo was bad but the IL2 was worse. From my experience, after a few days resting at home, the energy starts to come back fast. It helps that people aren't stealing your blood every day and taking your vital signs every 4 hours

Wishing you the best. /jdepp

Thanks all. Yes, I'm starting the chemo portion of the trial later today. Having read Akasleen's play-by-play and commentary, I have an idea of what to expect. Best wishes to everyone pursuing every strategy against cancer.

Just wanted to wish you good luck. I don't have good advice for you but would emphasize the importance of the surgeon's opinion.

Deb, I think you'll feel better the further you get from chemo. Great news on your scan.

As for me, I'm scheduled to start the TIL chemo on 2/23 & cell infusion on 3/2.

Great news. Good luck & best wishes!

My condolences for the loss of your father, who will continue to live with you in your memory.

I also want to thank you for helping so many, not just your father but all of us on this forum fighting cancer.

jdepp

I was diagnosed with 19 infected lymph nodes, too. Maybe we can start a club?

My advice is to let the chemo do its work. A lot of treatments are in development now and might well mature by the time you need them.

I'm looking forward to the NEJM article. I'm also in a chemo holding pattern since they harvested my tumors. I'm on regorafenib now and am exploring other trials, too. Good luck to everyone & thanks for being such a forthcoming pioneer, Sleen. Not everyone would be willing to go public, but you'...

Nik,

Hang in there. I've had reports exactly like that -- right down to the hilar node.

You can take some heart: things are still pretty small in your lungs, they're growing slowly, and a lot of good clinical trials are out there maturing. Hopefully they'll produce something good for us soon.

BB,

Thanks for the update. As always, I admire your fortitude & practicality -- which I try to share.

I wonder if you've looked at any clinical trials? Maybe there's an immunotherapy trial with your name on it?

Best wishes,

jdepp

Mille bornes, Frenchie!

I'm taking Lonsurf. The side effects aren't horrible, but I did set an all-time personal record low in ANC: 0.24.

Watch out for neutropenia.

Rock on, Rob! Great news! Yours in solidarity, jdepp.