You can look into the TAPUR trial for Keytruda. It is sponsored by ASCO and open almost everywhere with new cohorts. Google TAPUR and ASCO. However, be careful with immunotherapies; they can exclude you from a lot of trials if you fail but make you eligible for a few others. However, the scale is h...

A few more thoughts: With a 4.7cm tumor they are likely afraid that there may be some occult metastases that should be controlled with chemo before surgery. Using FOLFOX perioperatively (3 months or less before and again after surgery) is likely a good idea. However, I would question if you should u...

My onc has explained that EGFR inhibitors do not work on non-wild-type, but that they tend to perform better than Avastin for wild type. Amy sorry to butt in here. Centuximab (EGFR) is now only recommended in first line if you have a left sided tumor. Your signature didn’t say the location of your ...

I’ve seen doctors at UofM for years and now at the cancer center. I think it’s okay, but not great. Like anywhere your experience will vary by doctor. The UM medical system is quite disfunctional when it comes to administration (like most hospitals). It can take forever to get things scheduled. One ...

Boswind and all, Have you figured out if there is any correlation between the number of somatic variants/mutations listed and TMB? I noticed that Cynthia listed the 12 variants and her TMB is 12. I know gremline variants (those from your parents) don’t count toward TMB since the immune system likely...

Thank you all for sharing your experience with Pembrolizumab and MSS colon cancer. There is another hypothetical bio marker for checkpoint inhibitor response even for people with a low TMB. The idea for this biomarker came from the fact that renal cancer has a high response to checkpoint inhibitors ...