Menreq - I would think it's doable, although I wasn't on the monotherapy, I was stage IIIC, took Xeloda for 5.5 weeks during radiation and took Xeloda with Oxi (Xelox) for 6 rounds. I worked full time, not one day off during radiation. I had zero problems from the Xeloda, the Oxi kicked my butt and ...