I got my Pet scan results today. Nothing to surprising, more mets in my lungs, a 2.5 cm nodule in my maxillary antra. ( that is somewhere in my head, I have no idea where ). I also had a few nodules pop up here and there in various places. The only one I am curious about is the one in my head. Can ...

For those interested in DCVax-Direct, there are some encouraging developments. Northwest Biotherapeutics (company behind the technology platform) recently updated their pipeline, they are now planning a new phase I/II trial specifically for colon cancer metastases. What this may suggest is, from the...

http://www.prnewswire.com/news-releases/dcvax-direct-trial-update-indicates-further-positive-responses-3-case-studies-show-no-live-tumor-cells-in-injected-tumors-262686921.html Today the company released additional case studies. You can find some some of the more interesting tidbits below: in the o...

For those interested, Northwest Biotherapeutics, the company behind the DCVax technology, had a conference call discussing their press release on initial trial data for DCVax-Direct earlier this week. The summary of the call and the transcript of the Q&A portion are captured by a bio-tech stock ...

Maia, I am highly needle-phobic. Can't stand to look at one. I had a needle biopsy on one breast years ago that was just a cyst, but haven't needed anything since then. I'm not sure I could describe the location of the various lung nodules I have, but I would think at least some of them would be di...

Great find, Maia! Can't wait to hear what MD Anderson will say about this at ASCO later this week!

Here is the DCVax-Direct abstract

http://abstracts.asco.org/144/AbstView_144_132995.html

http://www.nhlbi.nih.gov/health//dci/Diseases/thrm/thrm_causes.html Secondary Thrombocytosis This condition occurs if another disease, condition, or outside factor causes the platelet count to rise. For example, 35 percent of people who have high platelet counts also have cancer—mostly lung, gastro...

http://www.marketwatch.com/story/nw-bio-announces-first-data-from-ongoing-dcvax-direct-trial-2014-05-15 The specific case study announced today involves a sarcoma patient with a large tumor mass and multiple inoperable metastatic tumors in the lung. This patient received the first 3 DCVax-Direct in...

Isn't Nivolumab an anti-PD-1 antibody? PD-1 is the cell surface receptor while PD-L1 is the ligand. Binding of the 2 sends activation/inhibition signals that is theorized to allow cancer cells to escape the body's immune system. From a mechanism of action standpoint, I think anti-PD-L1 antibodies wo...

Thanks for sharing the article, very interesting!

For those interested, an update was posted a few weeks ago in regard to the Phase I trial status. They are now hoping the trial would begin in Summer/Early Fall of this year. Although response was observed in a wide variety of cancer types (including solid tumors) in animal models using this anti-CD...

What to expect? Was diagnosed with Colon cancer early 2013. Had surgery to remove tumor, then started my long chemo treatment with some radiation in the middle. I completed my final chemo session in Sept 2013. I just had a 6 month follow up scan and it seems it has metastasis in both of my lungs. S...

It sounds like the experiments they have done so far are still in vitro, so I would expect any clinical trial using this newly created compound base on DCA to be at least a few years away.

I found the below paper to be very interesting and has real potential to be applied in the more effective treatment of CRC as the agents in the study work synergistically in a greater than additive fashion. Note-worthy quote: In vivo PX-866 / MK2206 and sorafenib / regorafenib cooperated to kill hep...