Insurance shouldn’t be the issue. People complain about health insurance in the US (and there are issues), but as a cancer patient, I’ll take an Obamacare plan vs European/Canadian public insurance any day. An ACA plan (Obamacare) may be more affordable than your employer’s COBRA especially if you'r...

I’m heading out to the beach for a few days with family to ponder life and not think about this for a while. I may not check in until I get back, damn this disease. I know this beach called scar reef on the island of Sumbawa, Indonesia from when I lived in Indo. Great surf, very chill/cheap BNB rig...

I would not do FOLFOX. Neuropathy often worses after discontinuing therapy, so you don’t event know how bad it is now. There is also increasing evidence that a shorter course of FOLFOX is as effective as a longer one. Sticking with 5FU/xeloda though is sensible. I don’t really agree that it would be...

Phase 1 study evaluating the safety, tolerability, pharmacokinetics (PK), and efficacy of AMG 510, a novel small molecule KRASG12C inhibitor, in advanced solid tumors. https://meetinglibrary.asco.org/record/172411/abstract Promising new agent/trial for anyone with KRAS mutation. KRAS has previously...

Sorry to hear about your story. I had a similar diagnosis in Jan 2017 (tough month). I’m sure you and/or your doctors have already looked into it, but have you confirmed that he doesn’t have mutations for some of the new (highly effective) targeted therapies? Was an NGS completed that looked for NTR...

Anyone know if the number of mutations increases after going through several different drugs? My mom had one mutation (KRAF?) back in 2015 when a biopsy was done. The jury is still out on this one. Caris just released a study for lung cancer that suggests chemo or radiation does not significantly i...

Phase 1 study evaluating the safety, tolerability, pharmacokinetics (PK), and efficacy of AMG 510, a novel small molecule KRASG12C inhibitor, in advanced solid tumors. https://meetinglibrary.asco.org/record/172411/abstract Promising new agent/trial for anyone with KRAS mutation. KRAS has previously...

Yeah, I had seen that. Good summary. Everyone should be ensuring they have been tested for the various actionable markers: trk/alk fusions, her2, msi/tmb, etc. I’ve seen oncologist discuss that they don’t know what to do about longer surviving patients that weren’t tested for trk fusions, if it’s wo...

Definitely thought about it for sure at first. But now, close to a year later I won’t unless I have to...

Not sure your situation. I have a j-pouch, and things sure get better with time...

JBell550 wrote:Thanks so much for your support Debs

JBell from the sound of it, you either have no cancer or hopefully very early stage disease. You should be in good shape now that it’s removed.

One more: ROCKET: A randomized, multicenter phase 2 study of RRx-001 + irinotecan coloreversus regorafenib in 3rd/4th line ctal cancer. https://meetinglibrary.asco.org/record/171796/abstract Sounds like they think there is enough evidence for a phase II approval for late stage CRC. I’m glad to see a...

Thanks Pyro70, very interesting. It’s not clear to me if they are using SBRT or just normal RT. If it’s SBRT it’s probably well-tolerated In the study design it’s shown as 8 Gy x 3 so I’m presuming this is indeed SBRT. Would be a strange RT regime otherwise? Yeah, I guess so. What’s interesting abo...

I went through the 200+ CRC abstracts released yesterday ahead of the ASCO 2019 annual meeting. I thought the following three abstracts were the most interesting and thought I’d share: A phase I study of PolyPEPI1018 vaccine plus maintenance therapy in patients with metastatic colorectal cancer with...

. It's sadly incumbent upon patients/caregivers to be aware of their situation, and all available [EVIDENCE BASED] treatment options. I wish you the best. There I fixed/clarified it (in bold). A good place to start with understanding treatment options are: NCCN guidelines, up-to-date, and onclive.c...

Catdylan1 Sounds like you are stressed enough. Please don’t let RP1954 create more stress/anxiety. Your doctors know what they are doing, listen to them. RP isn’t a doctor and his medical advice is not accepted by any national cancer guidelines. Don’t believe everything you read on the internet. The...