ALSO - this is a true grass-roots effort run by 3 simple activists... (me, Maia from CT and Jana Downing, a Stage IV MSS-CRC patient/activist not on CT). I KNOW we have/will miss the occasional trial that meets the curation parameters I have chosen to use [ 1.) Immunotherapy trial that allows MSS-CR...

CRguy wrote:
I have linked this topic into our permanent sticky for CLINICAL TRIALS and Important Links

CRguy

THANKS CR!!!

-DK

BIG ANNOUNCEMENT FOR CRC PATIENTS/GIVERS: AN ENTIRELY NEW MSS-CRC CLINICAL TRIAL FINDER BASED UPON MY PERSONAL CURATED CLINICAL TRIAL LIST! I’m excited to announce for the first time today a MAJOR advocacy project I have been working on for over a year now! Please read below and share – this is one ...

This is something I believe strongly in - so I'm cross-posting it across my multiple social media outlets: Here is a personal opinion CLINICAL TRIALS 101 post from my >20 years of being an oncology drug discovery scientist – intentionally just focused on the “big picture” questions. When should one ...

Linked below is my new column for the Philadelphia Inquirer “Cancer changes his Christmas, but can't take away his joy”. My goal of the column was to give the general newspaper & website readership a brief glimpse into some of the very personal impacts, positive and negative, having Stage IV can...

If you are curious to see what I consider my best 2016 posts from my scientist-patient-advocate blog "Adventures in Living Terminally Optimistic" here they are the list from yesterday's end of year blog. Here is hoping for a a Happy New Year 2017 for all of us! https://adventuresinlivingte...

HI EVERYONE! I heard from the NBC Producer today... it will still be aired (never fear), hopefully this week! Too much news going on right now ;) When I hear (probably the day of) it being aired - I will shoot out the info on social media. I noticed that the NBC Nightly News website archives stories...

I've posted many places over the past 1 1/2 years, I thought a PD1 inhibitor would be FDA-approved for MSI-high CRC by the end of 2016.

In a nailbiter, cutting it close...let's see how close those long range predictions were... certainly 100% chance of approval, just a matter of timing now!

-DK

Published today in the premier medical journal the New England Journal of Medicine - the story of Celine Ryan​ and her personalized immunotherapy success against her KRAS G12D Mutation. Yes only proof of concept but my blog "THE FACES OF SUCCESSFUL COLORECTAL CANCER IMMUNOTHERAPIES: VOL. 2"...

Maia wrote:Your trial, Tim UK! viewtopic.php?f=1&t=56553&p=447107#p447107
Other person doing well on this same trail at the MSK, 8 weeks into it (but slots on MSK are full by now : ( )

As I just said on the other thread - congrats Tim, fantastic news!!!!

-DK

https://clinicaltrials.gov/ct2/show/NCT02650713 Hi I moved onto Phase 1 trials a couple of months ago. I and my oncologist liked the science behind this one (above). It's a combination of bispecific antibody plus pd-l1 inhibitor. Previously I did 8 months on the (Phase 2/3) braf/MEK/egfr triplet wh...

Here's an interesting trial that I actually missed until recently. "A Study of the Safety, Pharmacokinetics, and Therapeutic Activity of RO6958688 in Combination With Atezolizumab in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen (CEA)-Positive Solid Tumors" ...

Here is a new MSS-CRC immunotherapy trial opening up at Johns Hopkins: "Phase 2 Study of GVAX (With CY) and Pembrolizumab in MMR-p Advanced Colorectal Cancer" https://clinicaltrials.gov/ct2/show/NCT02981524 It uses a very cool genetically modified listeria technology as therapeutic vaccine...

Thanks everyone who tried to tune in - still waiting to hear from NBC an updated broadcast plan... 9.3 Million (average) viewers - that is a lot of eyeballs looking at a guy with early on-set/young age MSS-CRC talking about CRC clinical trials! I think good for our CRC community to get that kind of ...

- so they are really apples and oranges (in terms of both potential toxicity and potential efficacy) and should be treated as such... AND, my addendum here, whose emphasis is underlined and hopefully UNDERLINES DK37's post "... in the context of an informed consent, doctor/patient relationship...