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by GrouseMan
Fri Feb 08, 2019 6:33 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Pump people recurrence question
Replies: 32
Views: 2998

Re: Pump people recurrence question

I would say if Dr K typically leaves them in for two years afterwards, she has seen enough cases justifying that recommendation. Its a good bet that she chose that time period for a reason. What's the harm? Leave it be.

GrouseMan
by GrouseMan
Thu Feb 07, 2019 5:21 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: BRAF...are there options we should be looking at?
Replies: 1
Views: 525

Re: BRAF...are there options we should be looking at?

Well you may want to have a look at the following: https://www.oncologynurseadvisor.com/colorectal-cancer/emerging-treatment-options-for-braf-mutant-colorectal-cancer/article/763563/ They have had pretty good success with using MEK inhibitors in Melanoma which have BRAF mutations so I am not surpris...
by GrouseMan
Sat Feb 02, 2019 9:51 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: cancer cure?
Replies: 9
Views: 1477

Re: cancer cure?

All I can add is that big Pharma is planning to make hundreds of billions MORE with new treatments. Yes - That's what these companies are supposed to do - make money for their share holders so they continue to invest in life saving drug research. Would you rather they make pizza instead? If you loo...
by GrouseMan
Fri Feb 01, 2019 8:53 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 37897

Re: Keytruda....Working for MSS....Mutation Burden is the Key

I posted this is the DK37 Science Posts topic but I thought everyone here might find this information useful. OK - I know plenty of you have an interest in MSI, MSS and TMB with regards to Immunotherapy agent usage. There have been a number of studies publish in the last year or so, but I have found...
by GrouseMan
Wed Jan 30, 2019 5:32 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 5FU infusions
Replies: 20
Views: 1879

Re: 5FU infusions

Ya - I was going to ask about this because its not the normal protocol. Usually one takes home the 5-FU/Leucovorin in the pump and the Oxaliplatin is done at the infusion center. Mainly because if one has an issue - its with the Oxy rather than the 5-FU and they like to keep an eye on you while you ...
by GrouseMan
Wed Jan 30, 2019 5:25 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: cancer cure?
Replies: 9
Views: 1477

Re: cancer cure?

Always be skeptical, but never lose HOPE! Much of our current advancements in CRC treatments came from similar research and development. The more research done, the better the opportunity for cures and better outcomes. Let's hope it has a positive affect to some people here on this forum. I often w...
by GrouseMan
Tue Jan 29, 2019 12:58 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: cancer cure?
Replies: 9
Views: 1477

Re: cancer cure?

Personally - I think this is overly hyped. They have just done mouse experiments, and they are a small research group. Having come from a Big Pharma Anti-cancer drug discovery group I know going from mouse experiments to humans takes much longer than a year. One drug I was involved with over 15 year...
by GrouseMan
Thu Jan 24, 2019 12:00 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: DK37 Science Posts List
Replies: 11
Views: 29381

Re: DK37 Science Posts List

OK - I know plenty of you have an interest in MSI, MSS and TMB with regards to Immunotherapy agent usage. There have been a number of studies publish in the last year or so, but I have found the following ones to be quite interesting, and I am hopeful that before long more people will have their tum...
by GrouseMan
Mon Dec 17, 2018 2:33 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Looking For Help With A Study
Replies: 5
Views: 1591

Re: Looking For Help With A Study

Everyone's cancers are different in their growth rates. There is no set time and honestly say it has anything to do with your service is going to be hard to prove. Somewhere on this forum I posted some information on doubling times for colon cancer based on some generalizations. Here is a link to it...
by GrouseMan
Sat Dec 15, 2018 10:30 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Frustrated, need your opinion
Replies: 4
Views: 1515

Re: Frustrated, need your opinion

They probably could see the Peri Mets when they did the colostomy. if they could be seen then its probably advanced. Peri Mets are what did my wife in. The very good surgeon that did her colon resection could see her Liver mets that the CT scan had shown, but didn't see any Peri mets. I am sure they...
by GrouseMan
Fri Dec 14, 2018 11:21 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Frustrated, need your opinion
Replies: 4
Views: 1515

Re: Frustrated, need your opinion

Your mom is in need of a second opinion I feel. In your signature is: 10/2/17 emergency colostomy (no resection, told tumor inoperable due to Mets found) That's a load of BS. Granted my wife didn't have rectal cancer but they still removed her primary colon tumor despite her having mets to her liver...
by GrouseMan
Fri Dec 14, 2018 10:59 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Beckman-Coultier CEA assays
Replies: 2
Views: 1086

Re: Beckman-Coultier CEA assays

The Beckman-Coulter DXL is just the instrument that they use to read the resulting immunoassay results from the Assay Kit. The individual Assay Kit could be from any number of Immunoassay test manufacturers. The instrument just reads the plate or vials. Typically these are fluorescent, or radiolabel...
by GrouseMan
Wed Dec 05, 2018 11:33 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Mannose possibly enhancing chemo
Replies: 3
Views: 788

Re: Mannose possibly enhancing chemo

Here is some additional commentary on this from "In The Pipeline": https://blogs.sciencemag.org/pipeline/archives/2018/12/05/mannose-and-cancer#comment-298184 In The Pipeline is a blog I read daily written by someone engaged in medicinal chemistry discovery. Someone that is doing the same ...
by GrouseMan
Tue Dec 04, 2018 1:47 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Newly Diagnosed
Replies: 5
Views: 1124

Re: Newly Diagnosed

I see from your signature that you will be after surgery starting FOLFOX plus Avastin, ( Avastin, Adrucil, Eloxatin) Pretty much the standard first therapy. Almost everyone on these forums started with FOLFOX and some added Avastin. My wife was able to pretty much kill off her spleen and Liver tumor...
by GrouseMan
Wed Nov 28, 2018 12:40 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: DK37 Science Posts List
Replies: 11
Views: 29381

Re: DK37 Science Posts List

Did i read the study right that it could work good with 5fu? Couldn’t make out if they were saying it was good with 5fu or diminished 5fu efficacy. Im on 2g of curcumin, 3g of micronized resveratrol, and low dose aspirin currently With my Folfox regimen. Interested in trying this if it plays well w...

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