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by GrouseMan
Fri Dec 14, 2018 10:59 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Beckman-Coultier CEA assays
Replies: 2
Views: 1021

Re: Beckman-Coultier CEA assays

The Beckman-Coulter DXL is just the instrument that they use to read the resulting immunoassay results from the Assay Kit. The individual Assay Kit could be from any number of Immunoassay test manufacturers. The instrument just reads the plate or vials. Typically these are fluorescent, or radiolabel...
by GrouseMan
Wed Dec 05, 2018 11:33 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Mannose possibly enhancing chemo
Replies: 3
Views: 701

Re: Mannose possibly enhancing chemo

Here is some additional commentary on this from "In The Pipeline": https://blogs.sciencemag.org/pipeline/archives/2018/12/05/mannose-and-cancer#comment-298184 In The Pipeline is a blog I read daily written by someone engaged in medicinal chemistry discovery. Someone that is doing the same ...
by GrouseMan
Tue Dec 04, 2018 1:47 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Newly Diagnosed
Replies: 5
Views: 1008

Re: Newly Diagnosed

I see from your signature that you will be after surgery starting FOLFOX plus Avastin, ( Avastin, Adrucil, Eloxatin) Pretty much the standard first therapy. Almost everyone on these forums started with FOLFOX and some added Avastin. My wife was able to pretty much kill off her spleen and Liver tumor...
by GrouseMan
Wed Nov 28, 2018 12:40 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: DK37 Science Posts List
Replies: 11
Views: 26569

Re: DK37 Science Posts List

Did i read the study right that it could work good with 5fu? Couldn’t make out if they were saying it was good with 5fu or diminished 5fu efficacy. Im on 2g of curcumin, 3g of micronized resveratrol, and low dose aspirin currently With my Folfox regimen. Interested in trying this if it plays well w...
by GrouseMan
Tue Nov 27, 2018 1:54 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: DK37 Science Posts List
Replies: 11
Views: 26569

Re: DK37 Science Posts List

OK since DK (Tom) has passed and we all miss him. And I see that few science posts have been made in a while - I thought I would post a link to something I read this morning concerning a Mushroom extract used in Taiwan that had been used to treat several conditions in folk medicine including bowel c...
by GrouseMan
Tue Nov 27, 2018 1:27 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Robotic surgery and LAR syndrome
Replies: 10
Views: 1173

Re: Robotic surgery and LAR syndrome

Thank you so much for this info. I think my surgeon wants to do my surgery robotically. Ask him how many he has done! If its only a few dozen vs the number he has done open - that might be an indication as to his experience. My wife's surgeon was a pioneer in the use of robotic procedures and was a...
by GrouseMan
Tue Nov 20, 2018 8:26 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Effect of meat (beef, chicken, and bacon) on rat colon carcinogenesis
Replies: 2
Views: 654

Re: Effect of meat (beef, chicken, and bacon) on rat colon carcinogenesis

Nice study - but then again this is in rats. The Cancer vs read meat and process meat correlation is just that really. A statistician will tell you right up front correlation does not equate to causality. It just might be a coincidence that people that eat a lot of red meet or bacon, have other char...
by GrouseMan
Tue Nov 20, 2018 7:56 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Update on husband, path report enclosed, please look
Replies: 3
Views: 811

Re: Update on husband, path report enclosed, please look

I doubt that I can talk you down any, but folks her can supply you with good information and aid you with their own experiences. We have had several members on this forum that have been diagnosed with Signet Ring Carcinoma as it is often called. It is rare to some extent statistically. But that real...
by GrouseMan
Mon Nov 12, 2018 9:55 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Elevation
Replies: 2
Views: 562

Re: Elevation

Yes - Chemo can increase cholesterol levels. Quick google search shows that a few studies indicate that at least in Breast Cancer the drugs they use do increase it. But they are different drugs for the most part. Still I think any chemotherapy will have an effect on the cardiovascular system. I woul...
by GrouseMan
Sun Nov 11, 2018 11:11 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: KRAS G12V and Avastin
Replies: 9
Views: 1197

Re: KRAS G12V and Avastin

The KRAS mutation itself does NOT rule out the use of Avastin which is an Antiangiogenic MAB. It interacts with VEGF-A and prevents solid tumors from recruiting the development of blood vessels to provide a food supply if you will. The KRAS mutation is not involved with the VEGF, FGF, PDGF pathway, ...
by GrouseMan
Sun Nov 11, 2018 10:43 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: RED, irritated face with Irinotecan + Vectobix
Replies: 6
Views: 709

Re: RED, irritated face with Irinotecan + Vectobix

This is an issue with the whole class of EGFr inhibitors. Both with the small molecule ones and the monoclonal antibodies. In the first clinical trials with Canertinib (CI-1033 one of the first EGFr inhibitors discovered) we would dose it with Benadryl, to minimize the rash. Later it was discovered ...
by GrouseMan
Wed Nov 07, 2018 9:41 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Almost 6 years
Replies: 29
Views: 2903

Re: Almost 6 years

Congratulations on the anniversary and the house! I will be closing on the sale of the House my wife and I built to retire to on Friday. She worked hard to pay it off so we would own it free and clear before we retired. Its a much nicer house than the one I live in now, but upon her diagnosis we sel...
by GrouseMan
Thu Nov 01, 2018 10:24 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Genome testing is back and looks really bad
Replies: 10
Views: 1149

Re: Genome testing is back and looks really bad

The vast majority of people that I've read about who know their mutation have only one mutation. I have seen some with a few mutations. I sent an email to my son to see if he has any comments on this sort of thing happening. That said, if this is contained to the tumor and they remove the tumor (or...
by GrouseMan
Thu Oct 25, 2018 2:56 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Hello
Replies: 2
Views: 602

Re: Hello

I would probably do the stents for the ureters, as that will at least help improve her kidney function and make her feel better. My wife had to have a stent put in when the tumor started to press just one of her ureters. They need to be replaced about every three months maximum, but its an out paten...
by GrouseMan
Tue Oct 23, 2018 10:20 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Isolation
Replies: 14
Views: 1911

Re: Isolation

Ya - the stoma isn't the end all you might think. I believe there are plenty of very active outgoing members that have them on the forums. Some still exercise, I might add vigorously, run swim and participate! I believe one was a rock climber another continued his martial arts training.... My wife i...

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