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by mpbser
Thu Jun 20, 2019 5:10 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Currently in the ER...woo.
Replies: 56
Views: 4251

Re: Currently in the ER...woo.

Thinking of you and sending vibes/prayers
by mpbser
Sun Jun 16, 2019 5:18 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Stage IV (with liver cyst) - 6 yrs NED
Replies: 12
Views: 2098

Re: Stage IV (with liver cyst) - 6 yrs NED

Has it ever been biopsied? My husband has (and had) a number of cysts (actually benign tumors called hamartomas) on his liver. We know they aren't cancerous because all have been biopsied. If yours hasn't been biopsied, the one characteristic that distinguished his benign masses from the cancerous o...
by mpbser
Sat Jun 15, 2019 5:46 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Our Miss Molly/Karen going into hospice
Replies: 47
Views: 8005

Re: Our Miss Molly/Karen going into hospice

Thank you for the update. I am glad to hear she is getting treated.
by mpbser
Fri Jun 14, 2019 6:56 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 5FU as second line?
Replies: 12
Views: 1243

Re: 5FU as second line?

Looking at that article you shared, julie, and see that "Significant resistance to 5-FU resulted from p53-loss or from gain-of-function (GOF) mutation (R248W)." My husband's mutation is [at least in the "first primary colon tumor"] "TP53 c.745A>G (p.R249G), exon 7 - in 34% o...
by mpbser
Fri Jun 14, 2019 6:29 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 5FU as second line?
Replies: 12
Views: 1243

Re: 5FU as second line?

Who would have thought that it could get even more complicated??? [/sarcasm]

Thanks for sharing. I look forward to spending the weekend reading about this and 5FU monotherapy. [/not sarcasm]

My husband's tp53 mutation was at exon 7. I'm not sure if that is a good or bad thing.
by mpbser
Thu Jun 13, 2019 12:34 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 5FU as second line?
Replies: 12
Views: 1243

Re: 5FU as second line?

Julie, Do you happen to know if your CC was tp53 mutated? I read, again as I have seen this expressed a number of times in various journal articles over the past couple years, that "CRC with mutated TP53 is resistant to 5-FU" in this extremely interesting article https://www.ncbi.nlm.nih.g...
by mpbser
Thu Jun 13, 2019 5:59 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: HELP. Mother’s treatment wrong?
Replies: 6
Views: 811

Re: HELP. Mother’s treatment wrong?

I LOVE all your questions. They tell me that you are paying close attention and caring about your mom. Here are my responses: - she’s being treated exclusively by general surgeon. She had informal mtg w oncologist when she was in the emergency room after the colonoscopy. As it was an emergency surge...
by mpbser
Wed Jun 12, 2019 4:02 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 5FU as second line?
Replies: 12
Views: 1243

Re: 5FU as second line?

No, I hadn't seen that. Thanks, LPL! I am familiar with the sad statistics cited in that website: even with the addition of leucovorin, only about 20 percent of mCRC patients respond to treatment, compared to approximately 10 percent response to 5-FU alone (J Clin Oncol 1989;7:1419-1426)... oxalipla...
by mpbser
Wed Jun 12, 2019 8:15 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Another 6 months
Replies: 13
Views: 1173

Re: Another 6 months

Awesome!
by mpbser
Wed Jun 12, 2019 5:30 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: On a Clinical Trial but I Think We're Reaching the End
Replies: 17
Views: 2099

Re: On a Clinical Trial but I Think We're Reaching the End

inorganic,

sending you positive vibes. You have been in my thoughts
by mpbser
Wed Jun 12, 2019 5:05 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 5FU as second line?
Replies: 12
Views: 1243

Re: 5FU as second line?

I guess I was using the term "second-line" without a full understanding of what it means. It may be easier to put my question another way: Has anyone done, or heard of doing, only 5FU (monotherapy) instead of Folifiri/etc after surgery for a liver met recurrence? My signature below may pro...
by mpbser
Tue Jun 11, 2019 2:09 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 5FU as second line?
Replies: 12
Views: 1243

5FU as second line?

Has anyone done, or heard of, only 5FU as a second-line treatment?

I would be very interested in learning the rationale behind such a decision. Thanks in advance!
by mpbser
Tue Jun 11, 2019 1:21 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Mop up chemo - Port vs non-port for Oxi?
Replies: 21
Views: 2151

Re: Mop up chemo - Port vs non-port for Oxi?

The chemo through a IV (PICC line) is supposed to be terrible on the blood vessels. My husband wrestled with the idea of a port. He really did not like the idea of it, made it feel like he was a cancer patient, and at that time he was having a hard time accepting the reality. So many people recommen...
by mpbser
Mon Jun 10, 2019 7:55 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: How safe is Coffee?
Replies: 12
Views: 906

Re: How safe is Coffee?

Interesting article, thanks for sharing. “It was demonstrated that roasting process had the most significant effect on acrylamide levels in natural coffee, however there were no relationships found with coffee species. Due to the high acrylamide levels demonstrated in coffee substitutes, recommended...
by mpbser
Mon Jun 10, 2019 4:30 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: How safe is Coffee?
Replies: 12
Views: 906

Re: How safe is Coffee?

I don’t believe acrylamide is naturally occurring. If it was found in coffee, there may have been some contamination from an external source.

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