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by ieowi
Thu Mar 17, 2016 11:43 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: arthritis painkiller drug have anti-cancer properties for colerectal cancer
Replies: 7
Views: 1436

Re: arthritis painkiller drug have anti-cancer properties for colerectal cancer

http://www.medscape.com/viewarticle/859945?src=wnl_edit_tpal&uac=165533BX#vp_2 "However, mutations in FBXW7 were associated with the absence of metastases and were seen in M0 patients across cohorts. This correlated with increased expression of T-cell proliferation and antigen-presenting f...
by ieowi
Thu Mar 17, 2016 8:47 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: arthritis painkiller drug have anti-cancer properties for colerectal cancer
Replies: 7
Views: 1436

Re: arthritis painkiller drug have anti-cancer properties for colerectal cancer

Ieowi, I lately learnt that the mutation your dad and I hold FBXW7 is highly immunogenic. He is also MSI low. Considering all this I think there is a good chance he might respond to immunotherapy meds. I am trying now to find off label pembrolizumab, although as I know he will not reopend only msi-...
by ieowi
Sat Jan 30, 2016 4:49 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: RE-POST - VITALLY IMPORTANT INFO: MSI-TESTING
Replies: 18
Views: 6447

Re: RE-POST - VITALLY IMPORTANT INFO: MSI-TESTING

I visited a doctor in my country in hope of getting drugs off-label. He didn't even know what is msi :x .
Unfortunately Not all doctors know what they should be knowing !!!
by ieowi
Sat Dec 05, 2015 9:01 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: End of the journey...No more treatment available
Replies: 17
Views: 3355

End of the journey...No more treatment available

we just left Memorial sloan, after they recommended radiation+pembrolizumab we decided to fly and visit them, apparently the procedure is not very effective "in there words" and my father have multiple tumors, you should only have one tumor to do this trial,, makes me wonder why recommendi...
by ieowi
Tue Dec 01, 2015 3:39 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: CRC/Immunotherapy Expert Roundtable Meeting This Week
Replies: 9
Views: 4572

Re: CRC/Immunotherapy Expert Roundtable Meeting This Week

Hope things turn out good for mss patients, as for us it's getting a bit late, we have to make a decision. We r seeing memorial Sloan next Friday, hope things work out well for my father.
by ieowi
Thu Nov 26, 2015 7:21 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: The end of our journey...
Replies: 31
Views: 5858

Re: The end of our journey...

These last 12 months have been so hard on my Dad and my Mom, my entire family. My Dad has reached the end of his journey, he will begin hospice care this week. We are all devastated, he has only just turned 60. So much life left to live, stolen by this awful disease. Thank you for all the support a...
by ieowi
Fri Nov 20, 2015 1:10 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Personal Blog Post: Time to Tread Some Water
Replies: 12
Views: 1527

Re: Personal Blog Post: Time to Tread Some Water

Good luck with the chemo DK37 hope all goes well.

Switching Siri on to listen to your article now 8)
by ieowi
Fri Nov 20, 2015 1:05 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Oxaliplatin Desensitization
Replies: 4
Views: 978

Re: Oxaliplatin Desensitization

Swinging roosters for you :mrgreen:

I wish u my very best...
by ieowi
Tue Nov 17, 2015 10:04 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: MDA Phase 1 trial Cons.
Replies: 12
Views: 1811

Re: MDA Phase 1 trial Cons.

Ieowi, You mention you still have one option at MSKCC. Can you share what that option is? Radiation , embolization with pembrolizumab. They said msi status doesn't matter. When I asked why you think it would work ? They said the destruction of the tumor using rd or embo. May trigger immune system t...
by ieowi
Tue Nov 17, 2015 8:43 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: MDA Phase 1 trial Cons.
Replies: 12
Views: 1811

Re: MDA Phase 1 trial Cons.

Ieowi, You mention you still have one option at MSKCC. Can you share what that option is? Radiation , embolization with pembrolizumab. They said msi status doesn't matter. When I asked why you think it would work ? They said the destruction of the tumor using rd or embo. May trigger immune system t...

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