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by boswind
Fri Oct 04, 2019 4:38 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: My final Journey will start next week
Replies: 1
Views: 494

My final Journey will start next week

Next Thur Oct 10 I will start either a phase 1 trial or take regorafenib. Basically, if the screen process indicates I am eligible for the trial, I most likely will start the trial. Currently I am communicating with the trial's principal investigator in order to have a few questions of mine on the t...
by boswind
Mon Sep 09, 2019 5:14 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Treatment at MSK
Replies: 25
Views: 1879

Re: Treatment at MSK

We called MSK after our second opinion at MD Anderson ended in a big fat no. Gathering the paperwork was a bit of a hassle. I had to hound a few offices to send the info over. After that got sent over, they reviewed it and said she would see DH. ... Hi kandj, Could you clarify " ... after our ...
by boswind
Tue Sep 03, 2019 6:25 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New TIL trial NCT03412877 at NCI
Replies: 9
Views: 564

Re: New TIL trial NCT03412877 at NCI

Most TMB tests are performed by Foundation One Medicine in Cambridge Mass. some hospitals like MSKCC have their own “TMB” type tests. If ordering a TMB test from Foundation One your oncologist needs to send a tumor sample to them.
by boswind
Tue Sep 03, 2019 5:17 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New TIL trial NCT03412877 at NCI
Replies: 9
Views: 564

Re: New TIL trial NCT03412877 at NCI

I was the first MSS patient receiving Keytruda in the cancer center where I receive treatments. I pushed my oncologist a bit to receive the drug, because my TMB was 12, which is within top 3% of all MSS CRC patients. But the drug failed on me. Now the cancer center has raised the TMB threshold to 20...
by boswind
Tue Sep 03, 2019 4:14 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New TIL trial NCT03412877 at NCI
Replies: 9
Views: 564

Re: New TIL trial NCT03412877 at NCI

Thanks. Wish your wife doing well in the TIL trial.

My KRAS-G12D is negative, but TP53 is positive. I have contacted NCI to start the screen process.
by boswind
Mon Sep 02, 2019 3:10 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New TIL trial NCT03412877 at NCI
Replies: 9
Views: 564

New TIL trial NCT03412877 at NCI

By visiting the website of Dr. Steven Roserberg’s lab of NCI today, I found he has another active TIL clinical trial that started last year in 2018 for solid tumors: NCT03412877 Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated Neoantige...
by boswind
Wed Aug 28, 2019 10:08 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Enhanced CAR-T cell activity against solid tumors
Replies: 2
Views: 479

Enhanced CAR-T cell activity against solid tumors

I came cross a research paper, published recently in Science, by an MIT team. The team developed a vaccine that could increase the numbers of CAR-T Cells in human body by up 200 times. Therefore, it would become realistic that CAR-T cells are to kill solid tumors. They plan to start clinical trials ...
by boswind
Thu May 16, 2019 4:23 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 35447

Re: Keytruda....Working for MSS....Mutation Burden is the Key

Based on the CT report and continuously rising CEA, my oncologist said Keytruda did not work on me. So I have to return to traditional chemos. I am now still in hospital to complete infusion of FOLFOX + Bevacizumab.
by boswind
Sun May 12, 2019 2:44 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 35447

Re: Keytruda....Working for MSS....Mutation Burden is the Key

Any one who took or is taking Keytruda has noticeable side affects? After the first infusion I did not notice side effects. But after my third infusion (Apr 25), I had some noticeable side effects: Beside fatigue, during the first week after infusion, I had moderate bone (leg) pain and muscle (calf)...
by boswind
Sun Apr 28, 2019 1:32 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 35447

Re: Keytruda....Working for MSS....Mutation Burden is the Key

Thank you all for your responses, which definitely reduce my stress level.
by boswind
Thu Apr 25, 2019 2:02 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 35447

Re: Keytruda....Working for MSS....Mutation Burden is the Key

Today is a bad day. My CEA has gone up by over 26 points over last 3 weeks, while my previous CEA (3 weeks ago) went up by 22 points over 4 weeks. However, based on my doctor’s analysis on all results of my lab work and his suggestion, I decided to continue and completed Keytruda infusion today. I w...
by boswind
Sat Apr 06, 2019 8:00 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 35447

Re: Keytruda....Working for MSS....Mutation Burden is the Key

@Pyro I read the following article posted on onclive.com: https://www.onclive.com/publications/Oncology-live/2019/vol-20-no-7/tumor-mutational-burden-poses-challenges-as-immunotherapy-biomarker It indicates TMB will be an challenging immunotherapy biomarker. Oncologists do not know if a specific pat...
by boswind
Sat Apr 06, 2019 1:20 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 35447

Re: Keytruda....Working for MSS....Mutation Burden is the Key

My CEA went up a lot from 12 to 34:

Mar 7: CEA=12
Mar 14: Keytruda
Apr 4: CEA=34.2 & 2nd Keytruda given

Doctor did not say much about the CEA; he just said the drug for mCRC MSS was too new and they were learning; they will monitor my side-effects closely.
by boswind
Sun Mar 31, 2019 3:38 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 35447

Re: Keytruda....Working for MSS....Mutation Burden is the Key

@Pyro I searched info about psuedo-progression on line, and found it is not based on variation of the CEA; it is based on variation of tumor size and the symptoms. Simply speaking, during a chemo drug is newly applied, if after the tumors initially become larger and/or the number of tumors increases...

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