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by boswind
Wed Feb 26, 2020 3:05 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Unconventional T cells capable of killing different types of cancer while sparing healthy cells
Replies: 2
Views: 482

Unconventional T cells capable of killing different types of cancer while sparing healthy cells

Any comments about this article recently published in Nature: Immunology: "Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1"? https://www.ncbi.nlm.nih.gov/pubmed/31959982/ https://acir.org/weekly-digests/2020/f...
by boswind
Wed Nov 06, 2019 1:37 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Regorafenib + Nivolumab - Immunotherapy might work in MSS CRC
Replies: 74
Views: 16235

Re: Regorafenib + Nivolumab - Immunotherapy might work in MSS CRC

Latest results from the Regonivo patients I’m tracking: *Total of 8 patients had their first scan or have stopped the combo. *2 patients have a potential response (seeing cavitation, but shrinkage isn’t at the 30% required by RECIST for an official response). *2 patients are stable *4 patients have...
by boswind
Fri Oct 25, 2019 5:33 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Regorafenib + Nivolumab - Immunotherapy might work in MSS CRC
Replies: 74
Views: 16235

Re: Regorafenib + Nivolumab - Immunotherapy might work in MSS CRC

Here are the two articles from where I drew my statement above. CORRECT Phase III trial https://ascopubs.org/doi/abs/10.1200/jco.2012.30.15_suppl.3502 Dominating Caucasian patients Arm of Regorafenib: Median PFS: 1.9 months Median OS: 6.4 months CONCUR Phase III trial https://www.ascopost.com/issues...
by boswind
Mon Oct 21, 2019 8:28 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Regorafenib + Nivolumab - Immunotherapy might work in MSS CRC
Replies: 74
Views: 16235

Re: Regorafenib + Nivolumab - Immunotherapy might work in MSS CRC

7 patients that I know of have had their first CT scans or stopped therapy. 4/7 have died or are in hospice and stopped therapy 2/7 are stable with slight increase in tumor size (could be pseudo progression) 1/7 is stable with no change in tumor size 0/7 have had a response (tumor shrinkage) There ...
by boswind
Fri Oct 04, 2019 4:38 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: My final Journey will start next week
Replies: 1
Views: 784

My final Journey will start next week

Next Thur Oct 10 I will start either a phase 1 trial or take regorafenib. Basically, if the screen process indicates I am eligible for the trial, I most likely will start the trial. Currently I am communicating with the trial's principal investigator in order to have a few questions of mine on the t...
by boswind
Mon Sep 09, 2019 5:14 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Treatment at MSK
Replies: 25
Views: 2742

Re: Treatment at MSK

We called MSK after our second opinion at MD Anderson ended in a big fat no. Gathering the paperwork was a bit of a hassle. I had to hound a few offices to send the info over. After that got sent over, they reviewed it and said she would see DH. ... Hi kandj, Could you clarify " ... after our ...
by boswind
Tue Sep 03, 2019 6:25 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New TIL trial NCT03412877 at NCI
Replies: 9
Views: 842

Re: New TIL trial NCT03412877 at NCI

Most TMB tests are performed by Foundation One Medicine in Cambridge Mass. some hospitals like MSKCC have their own “TMB” type tests. If ordering a TMB test from Foundation One your oncologist needs to send a tumor sample to them.
by boswind
Tue Sep 03, 2019 5:17 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New TIL trial NCT03412877 at NCI
Replies: 9
Views: 842

Re: New TIL trial NCT03412877 at NCI

I was the first MSS patient receiving Keytruda in the cancer center where I receive treatments. I pushed my oncologist a bit to receive the drug, because my TMB was 12, which is within top 3% of all MSS CRC patients. But the drug failed on me. Now the cancer center has raised the TMB threshold to 20...
by boswind
Tue Sep 03, 2019 4:14 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New TIL trial NCT03412877 at NCI
Replies: 9
Views: 842

Re: New TIL trial NCT03412877 at NCI

Thanks. Wish your wife doing well in the TIL trial.

My KRAS-G12D is negative, but TP53 is positive. I have contacted NCI to start the screen process.
by boswind
Mon Sep 02, 2019 3:10 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New TIL trial NCT03412877 at NCI
Replies: 9
Views: 842

New TIL trial NCT03412877 at NCI

By visiting the website of Dr. Steven Roserberg’s lab of NCI today, I found he has another active TIL clinical trial that started last year in 2018 for solid tumors: NCT03412877 Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated Neoantige...
by boswind
Wed Aug 28, 2019 10:08 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Enhanced CAR-T cell activity against solid tumors
Replies: 2
Views: 657

Enhanced CAR-T cell activity against solid tumors

I came cross a research paper, published recently in Science, by an MIT team. The team developed a vaccine that could increase the numbers of CAR-T Cells in human body by up 200 times. Therefore, it would become realistic that CAR-T cells are to kill solid tumors. They plan to start clinical trials ...
by boswind
Thu May 16, 2019 4:23 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 39018

Re: Keytruda....Working for MSS....Mutation Burden is the Key

Based on the CT report and continuously rising CEA, my oncologist said Keytruda did not work on me. So I have to return to traditional chemos. I am now still in hospital to complete infusion of FOLFOX + Bevacizumab.
by boswind
Sun May 12, 2019 2:44 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 39018

Re: Keytruda....Working for MSS....Mutation Burden is the Key

Any one who took or is taking Keytruda has noticeable side affects? After the first infusion I did not notice side effects. But after my third infusion (Apr 25), I had some noticeable side effects: Beside fatigue, during the first week after infusion, I had moderate bone (leg) pain and muscle (calf)...
by boswind
Sun Apr 28, 2019 1:32 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 39018

Re: Keytruda....Working for MSS....Mutation Burden is the Key

Thank you all for your responses, which definitely reduce my stress level.
by boswind
Thu Apr 25, 2019 2:02 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 39018

Re: Keytruda....Working for MSS....Mutation Burden is the Key

Today is a bad day. My CEA has gone up by over 26 points over last 3 weeks, while my previous CEA (3 weeks ago) went up by 22 points over 4 weeks. However, based on my doctor’s analysis on all results of my lab work and his suggestion, I decided to continue and completed Keytruda infusion today. I w...

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