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by GrouseMan
Wed Mar 17, 2021 9:06 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Nervous CEA rise
Replies: 12
Views: 1943

Re: Nervous CEA rise

Yes - My wife had a peri met that was not very well visualized by CT scans. I don't think they really got a good handle on it until it was large enough to cause a blockage of her colon by pressure from the outside. It was also pressing on her ureter requiring a stint. This was what did my wife in. L...
by GrouseMan
Tue Mar 16, 2021 1:57 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Nervous CEA rise
Replies: 12
Views: 1943

Re: Nervous CEA rise

Yes very definitely it could be something else. It appears that his CEA has always been in the normal range even when initially diagnosed at 4.9. For some this is not a good marker for CRC. Since he is having back pain, there is inflammation involved. And any inflamation can cause a rise in CEA. The...
by GrouseMan
Fri Mar 12, 2021 1:39 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: KRAS Q61H
Replies: 3
Views: 682

Re: KRAS Q61H

As catstaff indicates its rather one of the rare KRAS mutations found in CRC (~0.98% of all CRC), but is more predominate in Lung and Pancreatic cancers. There is apparently a Clinical Trial NCT03953235 which targets this mutation, and inclusion criteria is CRC and this mutation. See: https://www.my...
by GrouseMan
Thu Mar 11, 2021 1:52 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Calling ALL Colorectal CANUCKS !
Replies: 353
Views: 126119

Re: COVID vaccine rollout for Colorectal CANUCKS !

Topic has been too quiet .... SO Cheers everyone and “Let's Be Careful Out There.” CRguy (( bonus points if you can name that quote ... WITHOUT a search engine :twisted: :mrgreen: )) Hill Street Blues my friend. And no I didn't use a search engine. I was a fan of the show. Anyway, something I read ...
by GrouseMan
Tue Mar 09, 2021 6:00 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: KRAS Mutation G12V
Replies: 4
Views: 645

Re: KRAS Mutation G12V

You particular KRAS mutation is not one of the common ones that have a known resistance to KRAS pathway inhibitors. KRAS mutations are usually activating ones that result in turning pathways on that promote the release of growth factors that promote tumor growth. Sometime EGFr Inhibitors can be used...
by GrouseMan
Fri Jan 29, 2021 12:39 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: I'm getting worried
Replies: 69
Views: 26472

Re: I'm getting worried

I have been taking 10,000 IU of Vitamin D3 daily for some time now. A friend of mine was in an auto accident and banged up pretty bad. Long after she recovered, she had lingering pain. Her doctor put her on high dose Vitamin d and that helped a lot. So I decided to try it to see if it would help som...
by GrouseMan
Fri Jan 29, 2021 12:21 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Adjuvant Chemo Delayed
Replies: 3
Views: 1513

Re: Adjuvant Chemo Delayed

The large aortic aneurysm is much more deadly in the short term to your husband at this point than the cancer and must be dealt with first. Undergoing Chemo with a that would be dangerous, and the surgery to correct the aneurysm must heal before chemo. Lucky that they saw that! People drop dead from...
by GrouseMan
Mon Jan 25, 2021 10:40 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Wnt pathway
Replies: 4
Views: 1070

Re: Wnt pathway

In addition to this, members Maia and Grouseman, separately, posted a dozen or more messages referencing this topic also in the 2014 timeframe. I'll have to go back and review what Maia and I said on this topic 6+ years ago. Wnt is not an easy drug target from what I remember. A couple of other mem...
by GrouseMan
Wed Jan 20, 2021 5:03 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Avastin and Avascular necrosis
Replies: 2
Views: 937

Re: Avastin and Avascular necrosis

Yes - My wife was on it for almost 4 years. But She was not diagnosed with this side effect. She had some pretty bad lower back pain going on for about 6 months towards the end of her life. MRI etc didn't really sort out that back pain. Pretty inconclusive as to where it was coming from. I believe i...
by GrouseMan
Fri Jan 15, 2021 4:48 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: DK37 Science Posts List
Replies: 18
Views: 49926

Re: DK37 Science Posts List

OK - Its been a while since I posted something in this topic. Generally - I like to showcase some research that is probably directly applicable to the readers of this forum. I certainly don't have as good access to the journals and things that DK37 had or I for that matter 15 years ago. But I still ...
by GrouseMan
Wed Jan 13, 2021 12:48 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: How easy is it to differentiate between benign liver spots and small mets on a CT scan?
Replies: 12
Views: 3746

Re: How easy is it to differentiate between benign liver spots and small mets on a CT scan?

Imaging is not a very good means of differentiating one thing from another and it really takes specialists with a good eye to even see the very subtle changes in between scans. One would like to have the same radiologist compare the scans and hopefully not be the first or last of the day that they d...
by GrouseMan
Fri Jan 08, 2021 4:45 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: VEGF and TGF beta 1
Replies: 5
Views: 1276

Re: VEGF and TGF beta 1

I wouldn't disparage Avastin too much. I am surprised that you were not put on it at the time you had FOLFOX. Its side effects really are very minor when compared to the Oxaliplatin, 5-FU or Irinotecan. When My wife was on Irinotecan, Avastin and Erbitux without the 5-FU she thought that was a piece...
by GrouseMan
Tue Dec 29, 2020 1:58 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: COVID and Vitamin D
Replies: 5
Views: 1519

Re: COVID and Vitamin D

I have been taking High dose Vit D for a few years now. I don't spend a lot of time outdoors and when I do I cover up. I started taking it when a friend said it helped her with some joint and or bone pain. I had also read that its has a potential to be protective against colon cancer. I don't know i...
by GrouseMan
Thu Dec 10, 2020 11:47 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 1 year clear from stage IV
Replies: 22
Views: 4570

Re: 1 year clear from stage IV

Congratulations :!: :!: :!: Good news is good news and should be celebrated.

GrouseMan
by GrouseMan
Fri Nov 27, 2020 2:15 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: HAPPY THANKSGIVING!
Replies: 3
Views: 780

Re: HAPPY THANKSGIVING!

Yes - I had a very nice Thanksgiving holiday with my dearly departed wife's sister and her husband. I am grateful that they still include me as a member of the family especially seeing as I am dating another woman now who happens to be a breast cancer survivor (a mutual friend introduced us). Unfort...

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