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by GrouseMan
Thu Jan 04, 2024 1:09 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Scientists Destroy 99% of Cancer Cells in The Lab Using Vibrating Molecules
Replies: 1
Views: 1254

Re: Scientists Destroy 99% of Cancer Cells in The Lab Using Vibrating Molecules

Not a very practical means of treatment. Hard to get Near IR to penetrate very far into tissue. Good perhaps for some skin cancers. Aminocyanine like dye molecules have been the basis of many DNA in intercalators and are typically quite colorful. Getting the drug to the cancer systemically, is not v...
by GrouseMan
Thu Jan 04, 2024 12:47 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: AOH1996 Trial
Replies: 2
Views: 2700

Re: AOH1996 Trial

Here is a Wikipedia article that you might find interesting as well. https://en.wikipedia.org/wiki/AOH1996 its a small molecule inhibitor that is relatively simple. The synthesis I estimate is accomplished in about three steps from some simple commercially available materials that are not all that e...
by GrouseMan
Thu Aug 17, 2023 4:41 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: RELATIVITY trial
Replies: 5
Views: 1329

Re: RELATIVITY trial

I would be cautious - Lonsurf and Stivarga set such a low bar on success and side effects, for a big commitment (e.g. whither IVC and off labels, etc, and the pressures to stay an unpromising course when you've become ambivalent about trial success). Skipping to Phase 3 is still more like a Phase I...
by GrouseMan
Thu Aug 17, 2023 4:27 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Sigmoid + Distant Lymph Nodes
Replies: 33
Views: 8186

Re: Sigmoid + Distant Lymph Nodes

Thank you everyone for your feedback. Indeed we decided not to go with the watch and wait, it’s too risky. Boxhill — thank you for sharing. We’ve asked our oncologist about FOLFOX + Anti EGFR but he seem to suggest that both regimens are equally as effective, and he would keep this option open for ...
by GrouseMan
Thu Aug 17, 2023 4:00 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: My addiction to dark chocolate - did it lead to colon cancer? What can I do to detox?
Replies: 16
Views: 2059

Re: My addiction to dark chocolate - did it lead to colon cancer? What can I do to detox?

Interesting and informative What raised my eyebrow was how you spoke about HPV..I don't believe I have HPV I'm also a male so I believe as a male it's harder to contract? Also I have had the HPV vaccine however there was a period of time where I was frequently engaging in unprotected sex many times...
by GrouseMan
Mon Aug 14, 2023 11:58 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: My addiction to dark chocolate - did it lead to colon cancer? What can I do to detox?
Replies: 16
Views: 2059

Re: My addiction to dark chocolate - did it lead to colon cancer? What can I do to detox?

No - Dark chocolate had nothing to do with your cancer! You should not focus on such ridiculous reports. First of all, the numbers cited in your post don't make any sense. 166% of Lead based on what? Daily recommended dietary intake. Same with cadmium? Leafy greens, Potatoes, Peanuts, Grains includi...
by GrouseMan
Mon Aug 07, 2023 11:14 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Potential cancer breakthrough as 'groundbreaking' pill annihilates ALL types of solid tumors in early study
Replies: 1
Views: 1081

Re: Potential cancer breakthrough as 'groundbreaking' pill annihilates ALL types of solid tumors in early study

Very interesting research. Without looking up the synthesis I suspect it is pretty straight forward, and can probably be made, I am betting in about a 5-step synthesis in pretty high yields rather cheaply (turns out 3 steps as they bought their diphenyl ethers). The hard part is that it might be har...
by GrouseMan
Thu Jun 22, 2023 8:24 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New Treatment for Stage 4
Replies: 1
Views: 982

Re: New Treatment for Stage 4

Looks like a small molecule inhibitor of all three VEGFR Receptors. Avastin which is a MAB, interacts with VEGFR-1 and 2. So I guess you could sort of say it's a souped-up version of Avastin. It might be a while before it gets approval in the US. The molecule has similarity to a lot of Kinase inhibi...
by GrouseMan
Fri Mar 10, 2023 3:01 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Any avid runners with a ureteral stent?
Replies: 5
Views: 964

Re: Any avid runners with a ureteral stent?

My wife was a very avid distance runner and was training for a Marathon when she was diagnosed. Later on she had to have one of these stents put in as tumor was starting pinch off her Ureter. By that time she had already more or less quit running because the Chemo had resulted in her not having enou...
by GrouseMan
Mon Dec 05, 2022 12:26 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Update from Riki's Wife
Replies: 56
Views: 28726

Re: Update from Riki's Wife

I am very sorry for your loss Ruth. It is tremendously hard for those of us that are caregivers. I am happy that he told you he loved you. My wife was unconscious for the last several days of her life and we could not discuss our feelings. I was quite the wreck for some time afterwards. Took me more...
by GrouseMan
Mon Dec 05, 2022 12:05 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New to the forum
Replies: 13
Views: 3294

Re: New to the forum

I was also wondering if anyone knows if there is another forum or group that deals with people on immunotherapies? Even if they aren’t necessarily crc. I have had a difficult time finding anything. I have tried joining other cancer groups on FB, but they don’t seem to be very informed about cancer ...
by GrouseMan
Fri Dec 02, 2022 12:49 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New to the forum
Replies: 13
Views: 3294

Re: New to the forum

Looks like your DH is on the leading edge. The change in treatment from FOLFIRNOX to Yervoy+Opdivo may be due to the results of a biopsy indicating that the tumor was MSI-H or d-MMR which is a good thing when it comes to using Immunotherapy. Not very long ago this treatment would not have been avail...
by GrouseMan
Sat Nov 12, 2022 10:34 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Erbitux/Vectibix/EGFR rash trajectory
Replies: 5
Views: 2558

Re: Erbitux/Vectibix/EGFR rash trajectory

You might give Benadryl a try. In the early years of EGFr inhibitor clinical trials our first EGFr drug we had the trial patients take Benadryl and that seemed to help. Probably in combination with the oral antibiotic you are taking it might make things tolerable for you. My wife was on Erbitux for ...
by GrouseMan
Mon Sep 12, 2022 6:08 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Amgen’s Lumakras targets a mutation called KRAS that is common among many cancers
Replies: 0
Views: 1714

Re: Amgen’s Lumakras targets a mutation called KRAS that is common among many cancers

This is a small molecule inhibitor of the KRAS G12C mutated protein. Used for some people that have this particular mutation in Small Cell Lung Cancer. 30 to 50% of Colon cancers have KRAS Mutations and only a small percentage of those (3 to 4%) are of the G12C variety. In Small Cell Lung Cancer up ...
by GrouseMan
Wed Aug 31, 2022 7:24 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: KRAS Wild To A KRAS Mutation After 3 Years!
Replies: 2
Views: 2312

Re: KRAS Wild To A KRAS Mutation After 3 Years!

Not a surprise at all about the mutations. Mets often have different set of mutations than the Primary and even among themselves. I read a paper more than 16 years go on this subject I think it was. Hence the reason for multiple drug cocktails. I would stick with the Cetuximab (a monoclonal Antibody...

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