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by GrouseMan
Sun Jun 16, 2019 11:31 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Things I should know about Avastin
Replies: 13
Views: 527

Re: Things I should know about Avastin

My wife has been on Avastin for about four in a half years. It works with little side effects. Runny nose is the only thing I have seen. More importantly, It is not chemotherapy. The role of the drug is to take oxygen away from the cancer cells so they do not grow. Good Luck! WS Strictly speaking A...
by GrouseMan
Wed Jun 12, 2019 10:16 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: On a Clinical Trial but I Think We're Reaching the End
Replies: 17
Views: 1335

Re: On a Clinical Trial but I Think We're Reaching the End

And one more thing, because I need to vent a little: No, pharmaceutical companies are not hiding the cure so they can make more money. No, he has not tried coffee enemas, and he isn't going to... ever... EVER. And finally, now that the semester is over, I am going over to the local university and I...
by GrouseMan
Mon Jun 10, 2019 10:13 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: How safe is Coffee?
Replies: 12
Views: 501

Re: How safe is Coffee?

As a chemist I can say Acrylamides are ubiquitous in a lot of cooked foodstuffs coming about due to the degradation of amino acids. The cooking process often produces it in small amounts. On the other hand I have been drinking coffee ever since I was a toddler. My great grand mother use to spoon fee...
by GrouseMan
Tue Jun 04, 2019 1:33 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New Drug info
Replies: 1
Views: 270

Re: New Drug info

We already have a discussion about KRAS G12C going on here: http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=62546 that you might find interesting. AMG510 is a very similar structure small molecule inhibitor of a mutant form of the guanosine triphosphatase (GTPase) KRAS called ARS-162...
by GrouseMan
Thu May 30, 2019 9:18 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Potential Kras G12C inhibitor.
Replies: 7
Views: 455

Re: Potential Kras G12C inhibitor.

LPL - I have probably mentioned this before but people with KRAS G13D mutations are often relegated to the NO EGFr inhibitor treatment group along with all the other KRAS mutations. This is a biased position by many oncologist in that they can't wrap their head around the fact that G13D patients do ...
by GrouseMan
Tue May 28, 2019 7:16 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Potential Kras G12C inhibitor.
Replies: 7
Views: 455

Potential Kras G12C inhibitor.

The Kras G12C mutation occurs in about 7.9 % of colon Cancer patients tumors. So granted this isn't perhaps a great therapeutic discovery for colon cancer. However it seems that a good (150nM IC50) inhibitor - ARS-1620 is an atropisomeric one selective for KRASG12C a mutant form of the guanosine tri...
by GrouseMan
Tue May 28, 2019 12:17 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Avastin itch and rash
Replies: 11
Views: 751

Re: Avastin itch and rash

This is really an uncommon side effect from Avastin. But you may be encouraged from the following. https://www.ncbi.nlm.nih.gov/pubmed/17075324 This is a case reported in 2006 where a patient had such a rash attributed to Avastin. "This case report, we believe, is the first report of a possible...
by GrouseMan
Wed May 15, 2019 9:47 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Peanut related to cancer spread?
Replies: 3
Views: 608

Re: Peanut related to cancer spread?

This study is not new it dates from 2014. The Liverpool page cites the following paper. Here is a link to the original paper: https://www.ncbi.nlm.nih.gov/pubmed/25326505 No follow up that I can see from 2014. While they may still be studying this relationship much more needs to be done in my opinio...
by GrouseMan
Wed May 08, 2019 10:46 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Stage IV patient with increasing CEA: wait-and-see?
Replies: 3
Views: 495

Re: Stage IV patient with increasing CEA: wait-and-see?

Your mom might respond to a MEK inhibitor such as CI-1040, AZD6244 or Binimetinib as the NRAS mutation is more commonly found in Melanoma patients, and MEK inhibitors have found some success in those. See: https://www.mycancergenome.org/content/disease/colorectal-cancer/nras/77/ and: https://ckb.jax...
by GrouseMan
Mon Apr 15, 2019 8:09 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: What does "5-FU clearance" mean? Re: Xeloda
Replies: 4
Views: 433

Re: What does "5-FU clearance" mean? Re: Xeloda

Increased clearance could result in less effectiveness of the 5-FU and Decreased clearance could contribute to increased side effects. One should not mess around with these variables in drug phamacokinetics. Both these drugs effect 5-FU clearance by either increasing or decreasing metabolism by live...
by GrouseMan
Wed Apr 03, 2019 8:17 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: ***News Stories Thread*** ONGOING 2019
Replies: 54
Views: 12120

Cancer Preventive Vaccine Showed Promising Results in Preclinical Model of Lynch Syndrome

News of interest from AACR: Cancer Preventive Vaccine Showed Promising Results in Preclinical Model of Lynch Syndrome: Seems we may one day see a vaccine to help treat people diagnosed with Lynch Syndrome. In a mouse model of Lynch Syndrome they have discovered that treatment with an Oncolytic Vacci...
by GrouseMan
Thu Mar 28, 2019 3:49 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: ***News Stories Thread*** ONGOING 2019
Replies: 54
Views: 12120

Cancer immunotherapy may have a dark side

I see a recent article in Science that will be published soon that there are concerns the possibility that in a few instances that so called checkpoint inhibitors could be the cause of "hyperprogression" seen in a few patients. Some cancer researchers wonder whether it is simply an illusio...
by GrouseMan
Tue Mar 19, 2019 10:21 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Goodbye
Replies: 10
Views: 1159

Re: Goodbye

Sorry to hear about the passing of your mom. Sounds like she passed with a great deal of loving grace. Trying to make people smile up to the end. Have to agree that it seems very strange that your bothers mother in law would make such a scene. WT? Try to focus on your moms film jokes, that obviously...
by GrouseMan
Tue Mar 12, 2019 2:10 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: University of Michigan Hospital
Replies: 4
Views: 390

Re: University of Michigan Hospital

Like Deb m I also live in Pinckney but I used to work for PD/Pfizer in Ann Arbor. My wife was only in a Clinical trial there but they took great care of her while it lasted. Enormous amounts of clinical surveillance during a clinical trial there. We used St Joes for her primary care and standard tre...
by GrouseMan
Mon Mar 11, 2019 7:16 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Here's why cancer spreads to the liver
Replies: 4
Views: 787

Re: Here's why cancer spreads to the liver

I've been on this board for a good part of a year and I am continuously impressed with how smart some of you are. I'm no dummy, but you guys seem to grasp these concepts much easier than I do. (Do you have science backgrounds?) Thanks for sharing and for dumbing it down for some of us. :-) Yes some...

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