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by GrouseMan
Thu Sep 19, 2019 10:43 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Anyone taking artemisinin?
Replies: 2
Views: 81

Re: Anyone taking artemisinin?

I was interested in researching the possibilities of this in cancer research over 30 years ago when the chemical compound in this was originally identified and shown to contain a rather unique organic peroxide functional group. I built a case for investigating this to my department director, but he ...
by GrouseMan
Thu Sep 12, 2019 2:03 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: DK37 Science Posts List
Replies: 10
Views: 25830

Re: DK37 Science Posts List

OK - Its been a while since I posed anything scientifically interesting. But I saw an publication in Science Translational Medicine ( 11 Sep 2019: Vol. 11, Issue 509 ) which I found very compelling. Title: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials...
by GrouseMan
Thu Aug 22, 2019 10:27 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Phuong is the new ColonClub President !
Replies: 9
Views: 1010

Re: Phuong is the new ColonClub President !

Congratulations Phuong! Bets wishes for your role as ColonClub President!

Best Regards,

GrouseMan
by GrouseMan
Tue Aug 20, 2019 5:11 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Worrying symptoms
Replies: 13
Views: 1059

Re: Worrying symptoms

Why were they measuring CRP? This test is not found on the usual blood-test panels. They must have had a reason for testing and re-testing your CRP. CRP is a measure of inflammation. See: https://www.healthline.com/health/c-reactive-protein It is a simple blood test. IBS, and Crones disease usually...
by GrouseMan
Thu Aug 01, 2019 8:17 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Back after almost 10 years NED - Ascites, Peri & Liver Mets!
Replies: 28
Views: 3632

Re: Back after almost 10 years NED - Ascites, Peri & Liver Mets!

I still read the forum almost every day after having lost my wife a little more over 2 years ago. I was a former anticancer drug discovery chemist. I mostly come to read and sometimes post on new drug discoveries or research concerning colon cancer. My Wife was diagnosed Stage IVb at the onset. She ...
by GrouseMan
Wed Jul 24, 2019 11:45 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: leucovorin sodium chloride vs leucovorin d5w
Replies: 2
Views: 295

Re: leucovorin sodium chloride vs leucovorin d5w

It probably has to do with the fact that Oxaliplatin probably has better absorption and systemic effects using Dextrose than with Saline. 5-FU and Leucovorin in either probably makes little difference and I am betting Saline vs Dextrose solutions costs are substantially different so they switch. Har...
by GrouseMan
Fri Jul 05, 2019 1:23 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: "Second line" treatment for EGFR rash?
Replies: 5
Views: 682

Re: "Second line" treatment for EGFR rash?

You might also find the use of Benadryl useful. Early on when dosing CI-1033 (Predecessor to several EGFr inibitors) our clinician's put clinical trial folks taking CI-1033 on Benadryl which helped a great deal with the rash. Your mileage may vary but what's really the harm?

Good luck

GrouseMan
by GrouseMan
Sun Jun 16, 2019 11:31 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Things I should know about Avastin
Replies: 13
Views: 1074

Re: Things I should know about Avastin

My wife has been on Avastin for about four in a half years. It works with little side effects. Runny nose is the only thing I have seen. More importantly, It is not chemotherapy. The role of the drug is to take oxygen away from the cancer cells so they do not grow. Good Luck! WS Strictly speaking A...
by GrouseMan
Wed Jun 12, 2019 10:16 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: On a Clinical Trial but I Think We're Reaching the End
Replies: 17
Views: 1919

Re: On a Clinical Trial but I Think We're Reaching the End

And one more thing, because I need to vent a little: No, pharmaceutical companies are not hiding the cure so they can make more money. No, he has not tried coffee enemas, and he isn't going to... ever... EVER. And finally, now that the semester is over, I am going over to the local university and I...
by GrouseMan
Mon Jun 10, 2019 10:13 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: How safe is Coffee?
Replies: 12
Views: 809

Re: How safe is Coffee?

As a chemist I can say Acrylamides are ubiquitous in a lot of cooked foodstuffs coming about due to the degradation of amino acids. The cooking process often produces it in small amounts. On the other hand I have been drinking coffee ever since I was a toddler. My great grand mother use to spoon fee...
by GrouseMan
Tue Jun 04, 2019 1:33 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New Drug info
Replies: 1
Views: 477

Re: New Drug info

We already have a discussion about KRAS G12C going on here: http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=62546 that you might find interesting. AMG510 is a very similar structure small molecule inhibitor of a mutant form of the guanosine triphosphatase (GTPase) KRAS called ARS-162...
by GrouseMan
Thu May 30, 2019 9:18 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Potential Kras G12C inhibitor.
Replies: 7
Views: 711

Re: Potential Kras G12C inhibitor.

LPL - I have probably mentioned this before but people with KRAS G13D mutations are often relegated to the NO EGFr inhibitor treatment group along with all the other KRAS mutations. This is a biased position by many oncologist in that they can't wrap their head around the fact that G13D patients do ...
by GrouseMan
Tue May 28, 2019 7:16 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Potential Kras G12C inhibitor.
Replies: 7
Views: 711

Potential Kras G12C inhibitor.

The Kras G12C mutation occurs in about 7.9 % of colon Cancer patients tumors. So granted this isn't perhaps a great therapeutic discovery for colon cancer. However it seems that a good (150nM IC50) inhibitor - ARS-1620 is an atropisomeric one selective for KRASG12C a mutant form of the guanosine tri...
by GrouseMan
Tue May 28, 2019 12:17 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Avastin itch and rash
Replies: 11
Views: 1049

Re: Avastin itch and rash

This is really an uncommon side effect from Avastin. But you may be encouraged from the following. https://www.ncbi.nlm.nih.gov/pubmed/17075324 This is a case reported in 2006 where a patient had such a rash attributed to Avastin. "This case report, we believe, is the first report of a possible...
by GrouseMan
Wed May 15, 2019 9:47 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Peanut related to cancer spread?
Replies: 3
Views: 827

Re: Peanut related to cancer spread?

This study is not new it dates from 2014. The Liverpool page cites the following paper. Here is a link to the original paper: https://www.ncbi.nlm.nih.gov/pubmed/25326505 No follow up that I can see from 2014. While they may still be studying this relationship much more needs to be done in my opinio...

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