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by GrouseMan
Thu Oct 24, 2019 1:37 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Joe Rogers (1974-2019)
Replies: 10
Views: 582

Re: Joe Rogers (1974-2019)

Sorry for you loss. I like the Dr Who tribute in the Tardis cookie jar! I've still not found an appropriate container for my wife's ashes yet. They are still in the plastic box I received them in. You rock! I am sure he is pleased. I would be interested in hearing about the trials. Although I have l...
by GrouseMan
Tue Oct 08, 2019 4:13 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Promising new research
Replies: 4
Views: 523

Re: Promising new research

The original paper cited in the Cell Chemical Biology journal they also used CB-839 which is a Glutaminase Inhibitor which may be found in 6 Clinical Trials mostly having to do with Lung Cancer. Its all promising work, but very early stages using this combination of GLUT-1, and GLUT-3 transporter in...
by GrouseMan
Fri Oct 04, 2019 12:16 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: DK37 Science Posts List
Replies: 11
Views: 27048

Re: DK37 Science Posts List

Here is something interesting I came across today. It concerns supplemental Anti-oxidants and NAC (N-Acetyl Cysteine) in particular. Have a look at the following post in The Pipeline by Derek Lowe. https://blogs.sciencemag.org/pipeline/archives/2019/10/04/n-acetyl-cysteine-a-warning-shot Implication...
by GrouseMan
Mon Sep 23, 2019 9:58 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Anyone taking artemisinin?
Replies: 5
Views: 678

Re: Anyone taking artemisinin?

Her cancer was quite advanced and discovered far too late. No Chemotherapy would have been able to save her and she was not a candidate for surgery. Her oncologist was not open to a lot of unproven and by that I mean things not supported by clinical trials. I am not a doctor. I was a former drug dis...
by GrouseMan
Thu Sep 19, 2019 10:43 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Anyone taking artemisinin?
Replies: 5
Views: 678

Re: Anyone taking artemisinin?

I was interested in researching the possibilities of this in cancer research over 30 years ago when the chemical compound in this was originally identified and shown to contain a rather unique organic peroxide functional group. I built a case for investigating this to my department director, but he ...
by GrouseMan
Thu Sep 12, 2019 2:03 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: DK37 Science Posts List
Replies: 11
Views: 27048

Re: DK37 Science Posts List

OK - Its been a while since I posed anything scientifically interesting. But I saw an publication in Science Translational Medicine ( 11 Sep 2019: Vol. 11, Issue 509 ) which I found very compelling. Title: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials...
by GrouseMan
Thu Aug 22, 2019 10:27 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Phuong is the new ColonClub President !
Replies: 18
Views: 3284

Re: Phuong is the new ColonClub President !

Congratulations Phuong! Bets wishes for your role as ColonClub President!

Best Regards,

GrouseMan
by GrouseMan
Tue Aug 20, 2019 5:11 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Worrying symptoms
Replies: 13
Views: 1301

Re: Worrying symptoms

Why were they measuring CRP? This test is not found on the usual blood-test panels. They must have had a reason for testing and re-testing your CRP. CRP is a measure of inflammation. See: https://www.healthline.com/health/c-reactive-protein It is a simple blood test. IBS, and Crones disease usually...
by GrouseMan
Thu Aug 01, 2019 8:17 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Back after almost 10 years NED - Ascites, Peri & Liver Mets!
Replies: 28
Views: 4021

Re: Back after almost 10 years NED - Ascites, Peri & Liver Mets!

I still read the forum almost every day after having lost my wife a little more over 2 years ago. I was a former anticancer drug discovery chemist. I mostly come to read and sometimes post on new drug discoveries or research concerning colon cancer. My Wife was diagnosed Stage IVb at the onset. She ...
by GrouseMan
Wed Jul 24, 2019 11:45 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: leucovorin sodium chloride vs leucovorin d5w
Replies: 2
Views: 370

Re: leucovorin sodium chloride vs leucovorin d5w

It probably has to do with the fact that Oxaliplatin probably has better absorption and systemic effects using Dextrose than with Saline. 5-FU and Leucovorin in either probably makes little difference and I am betting Saline vs Dextrose solutions costs are substantially different so they switch. Har...
by GrouseMan
Fri Jul 05, 2019 1:23 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: "Second line" treatment for EGFR rash?
Replies: 5
Views: 745

Re: "Second line" treatment for EGFR rash?

You might also find the use of Benadryl useful. Early on when dosing CI-1033 (Predecessor to several EGFr inibitors) our clinician's put clinical trial folks taking CI-1033 on Benadryl which helped a great deal with the rash. Your mileage may vary but what's really the harm?

Good luck

GrouseMan
by GrouseMan
Sun Jun 16, 2019 11:31 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Things I should know about Avastin
Replies: 13
Views: 1179

Re: Things I should know about Avastin

My wife has been on Avastin for about four in a half years. It works with little side effects. Runny nose is the only thing I have seen. More importantly, It is not chemotherapy. The role of the drug is to take oxygen away from the cancer cells so they do not grow. Good Luck! WS Strictly speaking A...
by GrouseMan
Wed Jun 12, 2019 10:16 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: On a Clinical Trial but I Think We're Reaching the End
Replies: 17
Views: 2059

Re: On a Clinical Trial but I Think We're Reaching the End

And one more thing, because I need to vent a little: No, pharmaceutical companies are not hiding the cure so they can make more money. No, he has not tried coffee enemas, and he isn't going to... ever... EVER. And finally, now that the semester is over, I am going over to the local university and I...
by GrouseMan
Mon Jun 10, 2019 10:13 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: How safe is Coffee?
Replies: 12
Views: 890

Re: How safe is Coffee?

As a chemist I can say Acrylamides are ubiquitous in a lot of cooked foodstuffs coming about due to the degradation of amino acids. The cooking process often produces it in small amounts. On the other hand I have been drinking coffee ever since I was a toddler. My great grand mother use to spoon fee...
by GrouseMan
Tue Jun 04, 2019 1:33 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New Drug info
Replies: 1
Views: 504

Re: New Drug info

We already have a discussion about KRAS G12C going on here: http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=62546 that you might find interesting. AMG510 is a very similar structure small molecule inhibitor of a mutant form of the guanosine triphosphatase (GTPase) KRAS called ARS-162...

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