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by GrouseMan
Wed Mar 25, 2020 10:12 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: FOLFOX differences
Replies: 2
Views: 421

Re: FOLFOX differences

Mostly they differ in the timing and dosage of the components that make up the drug combination. Oncologists select the protocol based on their experiences more than anything else I think. Personal preference maybe. By and large I don't think there is much difference clinically in the outcomes depen...
by GrouseMan
Mon Mar 02, 2020 10:46 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: DK37 Science Posts List
Replies: 17
Views: 30739

Re: DK37 Science Posts List

Follow up about Vitamin C. I recommend a quick read of the following which gives some perspective and is bound to result in some discussion on Derek's Blog Forums. This is from In the Pipeline by Derek Lowe a Medicinal Chemist who is a well known blogger, of Chemistry and Drug Discovery: https://blo...
by GrouseMan
Wed Feb 26, 2020 3:14 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: DK37 Science Posts List
Replies: 17
Views: 30739

Re: DK37 Science Posts List

OK - Here is a new post on Vitamin C. We have in the past had members of this forum try High dose IV Vitamin C infusions to treat their cancers. Its been long held that this has anti-cancer properties, but so far not enough evidence, and certainly - I doubt it has done little more that stem the tide...
by GrouseMan
Wed Feb 12, 2020 10:31 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Hope vs reality
Replies: 9
Views: 1290

Re: Hope vs reality

Well - It was especially difficult for me as a caregiver, and former Anticancer drug discovery chemist. I very much knew what the diagnosed meant. The very advanced staging I pretty much knew what to expect, talk about despair that I tried very hard to keep to myself! My wife kept up a pretty positi...
by GrouseMan
Wed Feb 12, 2020 10:15 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Anyone heard about TAS102?
Replies: 4
Views: 455

Re: Anyone heard about TAS102?

Perhaps this link to Wikipedia will be useful. As I recall reading it seems to be more commonly used in Japan for some reason. https://en.wikipedia.org/wiki/Trifluridine/tipiracil Its a similar to Xeloda or 5-FU treatment, though is newer. I think if you search for it using the search function on th...
by GrouseMan
Thu Jan 09, 2020 4:14 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Zantac and Colon Cancer
Replies: 21
Views: 1922

Re: Zantac and Colon Cancer

Grouse Man, With these law suits, how on earth can they possible prove that the individuals cancer was specifically caused by the product or whatever they were exposed to? How did the guy who won his suit against round up weed killer prove that his cancer was caused by that specific product and tha...
by GrouseMan
Thu Jan 09, 2020 3:10 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Zantac and Colon Cancer
Replies: 21
Views: 1922

Re: Zantac and Colon Cancer

One of my friend has thyroid problems. She was on a medication that worked great, then suddenly she started having problems again. Looking into it, she learned that the manufacturing, which was originally all made in Germany (I think), had been outsourced to China; the active ingredient is the same...
by GrouseMan
Thu Jan 09, 2020 12:31 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Zantac and Colon Cancer
Replies: 21
Views: 1922

Re: Zantac and Colon Cancer

Ah, yes I see, but I feel this adulteration of the Zantac active ingredient was a recent issue, once it had gone OTC and its synthesis was farmed out to multiple API manufactures. See often years later a particular drug is not synthesized in the facilities owned by the patent holder or a pharma comp...
by GrouseMan
Tue Jan 07, 2020 6:10 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Zantac and Colon Cancer
Replies: 21
Views: 1922

Re: Zantac and Colon Cancer

It was recommended by 3 different OBs! Tums wasn't cutting it, so they said to get the Zantac. I mean, it totally helped with the heartburn. I just have to wonder if that might have caused my cancer. Maybe. Maybe it was just bad luck. Who knows. I'm just so pleased to be in NED status. No matter ho...
by GrouseMan
Tue Dec 10, 2019 11:23 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Still at the hospital :(
Replies: 34
Views: 4378

Re: Still at the hospital :(

Glad your husband is feeling better. That walking is very important to wake everything up again and to get things moving through the digestive system! His appetite should improve. Glad this has worked out well for him!

GrouseMan
by GrouseMan
Mon Dec 09, 2019 11:26 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Still at the hospital :(
Replies: 34
Views: 4378

Re: Still at the hospital :(

We did know about this recurrence in his colon.....he did have radiation on this area, but it obviously didn’t work....also, the initial plan for August’s surgery was to remove the nodes AND that section of his colon/rectum....the surgery was aborted to give him the opportunity to start treatment A...
by GrouseMan
Mon Nov 25, 2019 1:58 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: ***News Stories Thread*** ONGOING 2019
Replies: 90
Views: 38562

Re: ***News Stories Thread*** ONGOING 2019

garbovatwin! Welcome back - you have been missed!

GrouseMan
by GrouseMan
Fri Nov 22, 2019 10:31 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Pd-L1 high
Replies: 1
Views: 482

Re: Pd-L1 high

This means your dad might actually be a good candidate for a PD-L1 inhibitor. This is usually a bad sign as PD-L1 inhibits the immune system from attacking the cancer. Inhibition of this in people with high expression in combination with chemotherapy seems to have much better results. At least in lu...
by GrouseMan
Thu Oct 24, 2019 1:37 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Joe Rogers (1974-2019)
Replies: 10
Views: 1078

Re: Joe Rogers (1974-2019)

Sorry for you loss. I like the Dr Who tribute in the Tardis cookie jar! I've still not found an appropriate container for my wife's ashes yet. They are still in the plastic box I received them in. You rock! I am sure he is pleased. I would be interested in hearing about the trials. Although I have l...
by GrouseMan
Tue Oct 08, 2019 4:13 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Promising new research
Replies: 4
Views: 764

Re: Promising new research

The original paper cited in the Cell Chemical Biology journal they also used CB-839 which is a Glutaminase Inhibitor which may be found in 6 Clinical Trials mostly having to do with Lung Cancer. Its all promising work, but very early stages using this combination of GLUT-1, and GLUT-3 transporter in...

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